Acetyl tetrapeptide-2

Nnyocha nke Acetyl Tetrapeptide-2

1.Usoro nke Omume: Ntugharị mgbaàmà na ọrụ isi

Dị ka peptide na-egosi, Emebere Acetyl Tetrapeptide-2 ka ọ na-eṅomi (ruo n'ókè dị ukwuu) peptides endogenous mmadụ.

Specific 'ntụziaka’ a na-ebuga ya na mkpụrụ ndụ akpụkpọ ahụ; mmebi ihe owuwu jikọtara ya na usoro ịka nká bụ ihe ọ na-achọ ịgbanwe.

Isi ọrụ a kpọtụrụ aha n'elu – iguzosi ike n'ezi ihe na nkwado igwe emelitere maka dermis – bụ nzube ya akọwapụtara.

A na-ezo aka na okwu ọnụ dị ka “Peptide ike ndọda”, iguzogide sagging na-apụta ìhè mgbe niile dị ka otu n'ime ihe ndị kacha mkpa.

2.Na-arụgharị akpụkpọ ahụ Extracellular Matrix

Mkpali dị mkpa nke njikọ fibroblast bụ ihe Acetyl Tetrapeptide-2 na-enweta..

Ụdị m collagen bụ protein nhazi mbụ, A na-emeziwanye ịdị nro na ihe niile metụtara ike.

Otu nnyocha mere ka mmetụta ọ pụta ìhè – ruo 47.3% ahụrụ njikọ mụbara.
Ekwenyere na iwelite opekata mpe ụfọdụ mkpụrụ ndụ ihe nketa collagen bụ akụkụ nke usoro ya.

Na-abawanye ọnụọgụ zuru oke nke (nso na-adịgide adịgide) collagen dịnụ bụ ebumnuche njedebe n'ezie; wrinkles na niile jikọtara ogbenye udidi, na-ebelata.

3.Na-akwalite Synthesis Elastin na Mgbakọ Ọrụ

Nnyocha na-akwado na acetyl Tetrapeptide-2 na-akwalite mmepụta elastin nke ukwuu, na mmụba na-eru eru 21.7%.

Karia nka, ọ na-akwalite okwu mkpụrụ ndụ ihe nketa na ọkwa protein na-esote nke protein abụọ dị mkpa maka mgbakọ eriri na-arụ ọrụ. – FBLN5 (Fibulin-5) na LOXL1(Lysyl oxidase homolog 1).

FBLN5 na-eje ozi dị ka a “molekụla scaffold,” na-eduzi tropoelastin emepụtara ọhụrụ na microfibrils maka ntinye ziri ezi.

LOXL1, enzyme catalytic, na-eme ka njikọ dị n'etiti elastin monomers dị mkpa; na-akpụ netwọk eriri eriri kwụsiri ike.

Usoro mmekọrịta nke isi ihe abụọ a bụ ihe Acetyl Tetrapeptide-2 na-enweta – na-abawanye ma ọnụ ọgụgụ na mgbakọ na-arụ ọrụ nke elastin.

Na-emegide ike ndọda ozugbo, mmelite nke ịla azụ akpụkpọ na laxity bụ mmetụta a na-ahụ anya nke usoro a.

4.Mmetụta na Njirimara Mechanical Keratinocyte

HaCaT mkpụrụ ndụ bụ mmadụ anwụghị anwụ keratinocyte ahịrị cell nke a na-ejikarị na nyocha ihe gbasara anụ ahụ.

Ọgwụgwọ na peptide na-agbanwe ngbanwe nke mkpụrụ ndụ ndị a.

Na-agbasawanye ọrụ ya karịa fibroblast dermal dị mfe, imetụta ihe eji arụ ọrụ nke opekata mpe akụkụ nke epidermis bụ usoro nyocha dị mma na nke dị mkpa – nkwụghachi azụ anụ ahụ n'ozuzu ga-erite uru na mgbanwe ndị dị otú ahụ.

5.Ngwa na arụmọrụ

Site na usoro mgbochi ịka nká akọwapụtara nke ọma yana ọtụtụ ahịrị ma in vitro na ọmụmụ arụmọrụ mmadụ dabere, Acetyl Tetrapeptide-2 apụtala n'ezie dị ka ihe mgbakwunye kpakpando na nlekọta anụ ahụ nke ọgbara ọhụrụ..

Ikwusi ike na ibuli bụ isi ya, nso eluigwe na ala ngwa; ude, serum, ngwaahịa olu na ihe ọ bụla 'defy gravity’ Ụdị nhazi ga-enwe nke a mgbe niile na isi ha.
Collagen (na elastin n'otu oge) njikọ na-akawanye mma, ihe niile na-eduga na mweghachi ọzọ, ire ụtọ, na structurally soundly agadi akpụkpọ.

Mgbochi mgbochi ịka nká bụ ezigbo njedebe nke ihe a niile.