Acetyl Tetrapeptide-22 (aha njirimara Thermostressine®) bụ peptide sịntetik bioactive mejupụtara ihe fọdụrụ amino acid anọ, na mgbanwe N-terminal acetylated. A na-emezi mgbanwe a kapịrị ọnụ iji kwalite nkwụsi ike nke peptide na mwepu akpụkpọ ahụ na-esote. Na-eme dị ka peptide na-egosi, a na-emezi ya ka ọ na-eṅomi ụfọdụ akara molekụla anụ ahụ mmadụ na-eji; na-achịkwa ọrụ cell akpụkpọ ahụ ka ukwuu bụ ebumnuche bụ isi. Edere ya ka ọ bụrụ ihe nchekwa akpụkpọ anụ na mgbe ụfọdụ onye na-arụzi ihe, Ntinye aka zuru oke na ngwaahịa ịchọ mma na nlekọta onwe onye bụ nsonaazụ nke ọrụ a.
Usoro
Ac-His-Leo-Leo-Arg
Nọmba CAS
1295648-76-8
Usoro ihe omimi
C26H45N9O6
Ibu molekụla
579.69 g/mol
Nnyocha nke Acetyl Tetrapeptide-22
Acetyl Tetrapeptide-22 dara n'okpuru ezinụlọ biomimetic peptide – Ụdị acetylated bụ ihe a na-elekwasị anya n'ọtụtụ nchọpụta na-adịbeghị anya. Ịkwalite ọrụ mgbochi akpụkpọ ahụ na ụdị niile metụtara gburugburu ebe obibi bụ isi ihe kpatara nhazi ya dị ka ihe na-arụ ọrụ., 'Ndozi akpụkpọ ahụ’ ịbụ otu n'ime ojiji njedebe a na-arịọkarị. Acetylated peptides yiri ya (Acetyl tetrapeptide-2, Acetyl tetrapeptide-3 ọ bụrụ na ebe nchekwa na-ejere m ozi nke ọma) kekọrịta otu ebumnuche nhazi a; nkwụsi ike na nkwụsịtụ bụ isi njedebe a na-enweta site na usoro acetylation.
Ọrụ bụ isi nke ndu nke acetyl Tetrapeptide-22 na-ewusi sistemu nchekwa dị n'ime sel anụ ahụ ike.. Na-achịkwa Ndị na-edozi ahụ na-ekpo ọkụ (Ndị HSP) bụ nso mgbe niile na-elekwasị anya nke usoro ya.
Nnyocha n'ime usoro ziri ezi emeela ka nghọta ugbu a na Acetyl Tetrapeptide-22 na-arụ ọrụ dị ka ihe na-egosi molekul.. Keratinocytes (na ruo n'ókè sel anụ ahụ niile) kwalite njikọ nke HSP70 na nzaghachi nke peptide. HSP70 n'onwe ya na-edobe protein homeostasis; ịmata protein ndị mebiri emebi, iji ike nke ya ATPase okirikiri ka mpịaji ha ma ọ bụ ziga ha ka eweda ha ala. Mgbochi nke mkpokọta na ọnwụ cell zuru oke site na nrụgide siri ike bụ njedebe nke ihe a niile.
Mkpụrụ ndụ akpụkpọ ahụ (na sel niile ruo ogo ụfọdụ) ga-adị mgbe niile na-adịgide adịgide, obere ọkwa 'nchekwa’ steeti. Acetyl Tetrapeptide-22, na ihe niile yiri peptides, bụ na mgbe niile ga-adị, na-echebe ụfọdụ n'ókè nke nrụgide.
Ijikwa ọrụ ndu ya pụrụ iche, acetyl tetrapeptide-22 na-eje ozi dị ka ihe na-arụ ọrụ teknụzụ dị elu n'ime usoro ịchọ mma.. Ejikọtara ya na ngwaahịa nrụzi mgbakasị ahụ yana na-enye obi ụtọ, ọ na-echebe akpụkpọ ahụ pụọ n'aka ndị mmegide gburugburu ebe obibi dị iche iche kwa ụbọchị – anwụ ikpughe, mmetọ, oke ihu igwe bụ isi ihe atụ.
Ndozi akpụkpọ ahụ nwere mmetụta, post-ụda nke, na mmezi nkwụsi ike oge niile dabara nke ọma maka iji ya. N'otu oge, ụdị mgbochi ịka nká ga-agụnye ihe a. Na-echebe mkpụrụ ndụ site na apoptosis akabeghị aka yana ọdịda arụ ọrụ na-esote, ichekwa ma nke anụ ahụ na nke dị nso na-eto eto nke akpụkpọ ahụ bụ njedebe ikpeazụ; gburugburu ebe obibi na ruo n'ókè nke nrụgide physiological bụ ihe ịka nká na-anọchi anya.
Mpaghara nlekọta pụrụ iche ('nzọpụta’ ngwaahịa ma ọ bụrụ na ị ga-, ndị njem ugboro ugboro, ikwiikwii abalị, Usoro oge niile dabara ebe a) hụ mgbake ngwa ngwa nke opekata mpe obere ọnọdụ akpụkpọ ahụ dị ka nsonaazụ dị mma.
Acetyl Tetrapeptide-22 bụ peptide ịchọ mma na-ekwe nkwa; mmezi akpụkpọ ahụ na nchebe nrụgide niile metụtara ya bụ isi uru ya. Edemede ebipụtara ugbu a na-enye mkpughe nke usoro ọ bụla ma ọ bụ data ụlọ ọgwụ iji kwado nkwupụta ndị a. Nkọwa ngwaahịa ika na-akwalite oke nke ihe anyị maara, na peptides yiri ya (ma nọgide na-adị) gụrụ akwụkwọ.
Na-akwado n'ụzọ zuru ezu nke usoro ndu na ụlọ ọgwụ nke a ma ọ bụ peptide ọ bụla, bụ ezigbo ọdịnihu sayensị ịchọ mma.
COA
HPLC
MS
