Acetyl Tripeptide-1 bụ mgbama nrụzi synthetic peptide, synthesized site N-terminal acetylation (mgbanwe "capping".) nke tripeptide GHK na-apụtakarị n'ime plasma ma nwee usoro kemịkalụ yiri acetylated Polypeptide-1. Ngbanwe nhazi a na-eleba anya n'ihe ịma aka ndị a kpọtụrụ aha na mbụ nke GHK mbụ, gụnyere enweghị ike n'ihi aminooxidases, inactivation na ịchọ mma formulations, na obere ọkara ndụ.
Na nchịkọta, Acetyl Tripeptide-1 na-ebelata ahịrị dị mma na wrinkles, tightens akpụkpọ, ma na-anụcha ọdịdị akpụkpọ ahụ. Ọ bụ ihe mgbochi ịka nká nke nwere usoro ihe omume doro anya, elu nkọwapụta, ma gosipụta arụmọrụ.
Usoro
Ac-Gly-His-Lys-OH
Nọmba CAS
350595-76-5
Usoro ihe omimi
C16H26N6O5
Ibu molekụla
382.42
Nnyocha metụtara Acetyl Tripeptide-1
1.Usoro isi na mmetụta ọtụtụ akụkụ
Ihe ngosi GHK acetylated mụbara hydrophobicity na ọkara ndụ ogologo oge ka ị na-echekwa Cu²⁺ ya nwere ike ịgbanwe-chelation Njirimara. Ngwongwo ndị a na-enyere aka ịmepụta ogige ọla kọpa-peptide n'ime oyi akwa dermal, na-eme ka arụmọrụ na-abawanye ụba cytotoxicity.
Ọ na-eme na dermal fibroblast sel iji gbochie ịka nká nke ihe ngụkọ oge ma ọ bụ ihe gburugburu ebe obibi na-ebute. Site na ijikọ kpọmkwem ihe ndị na-anabata elu cell, ọ na-eme ka nnukwu ihe nrịbama intracellular rụọ ọrụ ka ọ gbanwee ọrụ cellular na ọkwa mkpụrụ ndụ ihe nketa.
Ọ na-akpali njikọ na nzuzo nke Ụdị I nke ọma & III collagen na elastin, na-akpata denser, oke akpụkpọ. Nke a, n'oge ya, na-ebelata wrinkles, sagging, na oghere nke kpatara mfu collagen.
Ọ na-egbochikwa ọrụ metalloproteinase matrix gabiga ókè, iguzobe microenvironment akpụkpọ ahụ na-echebe nke na-ebelata mmebi nke matriks extracellular nwa afọ.
2.Na-akwalite collagen na elastin synthesis
Acetyl Tripeptide-1 na-erute oyi akwa akpụkpọ ahụ, ebe ọ na-eme dị ka a ligand maka ndị na-anabata ya kpọmkwem na akpụkpọ ahụ sel fibroblast. Njikọ a na-arụ ọrụ protein kinase nke mitogen na-arụ ọrụ (MAPK) na phosphoinotide 3-kinase (PI3K) ụzọ mgbaàmà, na-akwalite mgbasa nke fibroblast na ịkwalite elu anabolic metabolism.
Na transcription ọkwa, ọ na-eme ka okwu na njikọ nke Ụdị I collagen dịkwuo elu, Ụdị nke III collagen, na elastin, si otú ahụ na-amụba itinye uche na njupụta ha na dermis. Nke a na-eduga na plumper, ọzọ voluminized akpụkpọ. ¹
3.Na-egbochi oke oke Matrix Metalloproteinase Nkwuputa
Acetyl Tripeptide-1 na-agbanwe akara ngosi ekwentị iji gbochie oke mmepụta nke matrix metalloproteinases. (Ndị MMP), ka ọ na-ebelatakwa na-aga n'ihu extracellular matriks nbibi site n'imebi njikọ ha na ọkwa ederede.
Ichekwa collagen dị adị site na usoro a na-enyere aka ịnọgide na-enwe oke na iguzosi ike n'ezi ihe, na-agbatị oge ntụgharị nke collagen, ma si otú a na-enye aka n'igbu oge usoro ịka nká. ²,³
4.Na-akwalite Ọrụ Mmezi Skin Cellular
Acetyl Tripeptide-1 na-arụ ọrụ PI3K/Akt ụzọ, isi ihe na-achịkwa ndụ cellular, uto, na metabolism. Ihe mkpali a na-akwalite ọrụ fibroblast ma na-eme ka mmezi nke microtrauma kwa ụbọchị.
Ọ na-ewepụkwa radicals efu ewepụtara site na catalysis metal-ion, si otú na-apụtaghị ìhè na-egbochi nrụgide oxidative-kpatara mmebi cellular na ịkwalite akpụkpọ ahụ ka mma. .
COA
HPLC
MS
