Name: Adamax
Brand: MOL Changes
SKU: 198802

Adamax bụ ihe sịntetik heptapeptide sitere na anụghị; Usoro amino acid a kapịrị ọnụ bụ Ac-MEHFPG-AG-NH₂.

Semax n'onwe ya, Iberibe nke adrenocorticotropic homonụ (ACTH), nwere neurotrophic dị ike na ihe na-eme ka ọgụgụ isi.

Oke ihe owuwu n'ime semax na-eduga na oke oke na ọkara ndụ ya na arụmọrụ nke ịgafe mgbochi ụbụrụ ọbara..

Iji belata oke ndị a ndị ọkà mmụta sayensị webatara otu nnukwu adamantylacetate site na njikọ nke covalent na ọdụ ụgbọ elu carboxyl.

Ngbanwe a mere ka ọ dịkwuo mma Njirimara pharmacokinetic nke peptide molekul.

Mmalite nke akụrụngwa a na-enye nso nso a nguzogide zuru oke na-esote mmebi nke enzymatic; oge njigide nke ụdị ọrụ nke adamax n'ime ahụ na-agbatị ogologo oge.

Na-atọ ụtọ karịa, nke a kpọtụrụ aha na mbụ 'amamihe’ imewe na-akwalite mmụba na arụmọrụ nke peptide obe kwuru ihe mgbochi, na emelitere nkọwapụta na nhọrọ nhọrọ.

Na-emebi enweghị ọrụ ndu, A na-edobe mmetụta niile amaara nke semax ma ọ bụ kwalite.

Usoro

Ac-MEHFPGP-Adam-NH2

Nọmba CAS

Usoro ihe omimi

C50H68N10O12S

Ibu molekụla

1033.212

Nnyocha nke Adamax:

1.Ịrụ Ọrụ Ọgwụgwọ na Pụrụ Ime Ọgwụ

Nnwale ụlọ ọgwụ egosila Adamax ka ọ dị elu karịa Semax n'ịkwalite uto na nchebe nke ụbụrụ na-enweta neurotrophic ihe (BDNF) na ruo n'ókè ihe na-akpata akwara uto (NGF).

Dochie Semax dị ka onye na-ahụ maka ọgwụgwọ, karịsịa maka ọrịa mgbaka ma ọ bụ nkwalite mmekọrịta mmadụ na ibe ya, bụ nnọọ ekwe omume.

2.Nkwalite ọgụgụ isi (ọgụgụ isi bụ subset)

Nkwalite ozugbo nke nkwalite BDNF bụ isi ọrụ Adamax.

Ọrụ cell neuronal, Ọgbọ neuron ọhụrụ / dị iche iche yana nkwalite synapti niile metụtara bụ ihe nyocha a lekwasịrị anya ugbu a.

A na-abawanyekwa ọrụ hippocampal na prefrontal cortex.

Otu nnwale ogologo oge nwere ma ga-aga n'ihu na-egosi, ọnụọgụgụ, ebe nchekwa dị elu na ikike mmụta.

3.Mmetụta Neuroprotective

Nkwalite nghọta Adamax na ọrụ ịkwalite ọgụgụ isi sitere na ọ bụghị naanị site na nkwalite ya kpọmkwem nke uto mkpụrụ ndụ akwara., kamakwa site na ngosipụta neuroprotective Njirimara.

Egosiputara mbelata nke ọma nke mpaghara infarction ụbụrụ na ndị ọrịa strok; mkpali na mgbake nke mkpụrụ ndụ necrotic dị iche iche bụ akụkụ ọzọ dị mkpa nke neuroprotection a.

Na-ebelata excitotoxicity na inye mmetụta antioxidant dị nso na-adịgide adịgide bụ ihe mgbakwunye, ihe omume edekọtara nke ọma.

Debe onwe ya n'ime mpaghara a, Adamax na-ekwe nkwa dị ka ezigbo onye na-ahụ maka ọgwụgwọ maka ọrịa neurodegenerative – Alzheimer bụ ihe atụ kachasị, Parkinson na-esochi anya n'azụ.

4.Nchegbu na Nchegbu

Adamax na-akwalite ikike mmadụ ime mgbanwe na mgbanwe gburugburu ebe obibi; ụbụrụ n'onwe ya ga-agbanwe ngwa ngwa, ma guzogide, ụdị nrụgide physiological dị iche iche na-esite na mgbanwe gburugburu ebe obibi ndị a ngwa ngwa.

Ịdokwa ụdị ụfọdụ nke homeostasis bụ njedebe njedebe.

Modulation nke hypothalamic-pituitary-adrenal (HPA) axis bụ isi na usoro a, na-abawanye ma ọ bụ na-ebelata ntọhapụ kwesịrị ekwesị nke neurotransmitters, Nzaghachi nchegbu niile dị obere’ na-egbochi.

Anxiolytic mmetụta bụ isi uru – iro ụra na enweghị ọgụgụ isi (nso nso eluigwe mmetụta mmetụta nke omenala anxiolytics) a na-ezere kpamkpam.

Ịkwalite ọrụ ọgụgụ isi n'oge ụdị ọ bụla nke enyemaka nchekasị bụ ihe na-eme Adamax na-adọrọ mmasị karịsịa nye ndị nchọpụta na ndị ọrịa..

COA

HPLC

MS

(1)Ọnụ, N. V.; Sokolov, O. Y.; Gabaeva, M. V.; Grivennikov, I. A.; Andreeva, L. A.; Myasoedov, N. F.; Zozulya, A. A. Semax na Selank na-egbochi Enkephalin-Degrading Enzymes nke Serum mmadụ. Akwụkwọ akụkọ Russian nke Bioorganic Chemistry 2001, 27(3), 156-159. DOI: 10.1023/a:1011373002885.

(2)Vlasova, I. M.; Buravtkov, D. E.; Saletsky, A. M. Nyocha luminescence nke ihe mejupụtara ọbara na nyocha nke akụrụngwa neuroprotective nke ọgwụ "Semax" na ischemia cerebral.. Akwụkwọ akụkọ Applied Spectroscopy 2009, 76(1), 121-126. DOI: 10.1007/s10812-009-9141-y.

(3)Abraham, M. H.; Acree, W. E.; Liu, X. Nkowa maka adamantane na ụfọdụ usoro ya. Akwụkwọ akụkọ Liquids Molecular 2021, 325. DOI: 10.1016/j.molliq.2020.114894.

(4)Dane, C.; Montgomery, A. P.; Kassio, M. The adamantane scaffold: N'ofe akụkụ lipophilic. Akwụkwọ akụkọ European nke ọgwụ Chemistry 2025, 291. DOI: 10.1016/j.ejmech.2025.117592.

(5)Dmitrieva, V. G.; Povarova, O. V.; Skvortsova, V. I.; Limborska, S. A.; Myasoedov, N. F.; Dergunova, L. V. Semax na Pro-Gly-Pro na-arụ ọrụ ntụgharị nke Neurotrophins na Genes Nnabata ha mgbe Cerebral Ischemia gasịrị.. Neurobiology cellular na molecular 2009, 30(1), 71-79. DOI: 10.1007/s10571-009-9432-0.

(6)Eremin, K. O.; Kudrin, V. S.; Saransari, P.; Ngwaahịa, S. S.; Grivennikov, I. A.; Myasoedov, N. F.; Rayevsky, K. S. egela ntị, Otu ACTH(4-10) Analogue nwere Nootropic Properties, Na-arụ ọrụ Dopaminergic na Serotoninergic Brain Systems na Rodents. Nnyocha Neurochemical 2005, 30(12), 1493-1500. DOI: 10.1007/s11064-005-8826-8.

(7)Glazova, N. Y.; Manchenko, D. M.; Volodina, M. A.; Mercieva, S. A.; Andreeva, L. A.; Kudrin, V. S.; Myasoedov, N. F.; Levitskaya, N. G. egela ntị, ACTH sịntetik(4-10) analog, na-ebelata mgbanwe omume na neurochemical na-eso mkpughe fluvoxamine nke oge ndụ na oke ọcha. Neuropeptides 2021, 86. DOI: 10.1016/j.npep.2020.102114.

(8)Medvedev, E. V.; Dmitrieva, V. G.; Limborska, S. A.; Myasoedov, N. F.; Dergunova, L. V. egela ntị, analog nke ACTH(4-7), na-achịkwa ngosipụta nke mkpụrụ ndụ ihe nketa nzaghachi mgbochi n'oge mmerụ ahụ ụbụrụ ischemic na oke. Mkpụrụ ndụ mkpụrụ ndụ ihe nketa na Genomics 2017, 292(3), 635-653. DOI: 10.1007/s00438-017-1297-1.

(9)Pae, C.-U. Enwere ike ọgwụgwọ nke "Semax" maka ịda mbà n'obi. Ụdị ụdịdị CNS 2014, 13(1), 20-21. DOI: 10.1017/s1092852900016102.

Usoro:	Ac-MEHFPGP-Adam-NH2
CAS:	N/A
M.W:	1033.21g/mol

Adamax