Tetrapeptide - 4

Nnyocha metụtara Tetrapeptide-4

A na-ekewa Tetrapeptide-4 dị ka "peptide na-egosi", nke na-egosi na ọ na-ezigara mkpụrụ ndụ akara kama ịbụ akụkụ n'ezie nke nhazi cellular.

Ọrụ ya bụ isi na-egbochi ịka nká na-adabere na nrụzi na nhazi nke matrix extracellular akpụkpọ ahụ (ECM).

1.Ịkwado nke Collagen na Elastin Synthesis

Usoro ịka nká nke akpụkpọ ahụ bụ ndakpọ na ECM nke nwere mfu na arụ ọrụ nke collagen, elastin, na fibronectin.

Isi ọrụ nke Tetrapeptide-4 bụ ịlaghachi ma ọ bụ belata usoro ịka nká a.

Ọtụtụ ihe akaebe na-akwado na Tetrapeptide-4 na-abawanye njikọ nke protein atọ a dị mkpa nke ọma..

Site n'ịkwalite ịdị elu synergistic nke ọkwa ha, Tetrapeptide-4 nwere ike melite iguzosi ike n'ezi ihe nke akpụkpọ ahụ, ibelata wrinkles na ime ka akpụkpọ ahụ dịkwuo kọmpat ma na-agbanwe.

2.Na-akpali Ihe na-agbanwe Uto-β (TGF-β) Hapụ

Ọtụtụ ọmụmụ na-eme ka o doo anya na Tetrapeptide-4 na-ejikọta ya na ndị na-anabata ya nke dị na akpụkpọ ahụ., tumadi na fibroblasts.

Njikọ a na-eme ka cascades mgbaàmà intracellular rụọ ọrụ.

Nsonaazụ ngwụcha nke cascades ndị a bụ nkwalite ihe na-agbanwe uto-β (TGF-β) mmepụta.

TGF-β bụ otu n'ime ihe kacha mkpa cytokines na-etinye aka n'ịhazi njikọ matrix extracellular.

A na-akpọ ya "nna ukwu mgba ọkụ" na-achịkwa mmepụta nke collagen, Fibronectin na elastin.

3.Na-abawanye fibronectin na glycosaminoglycan mmepụta

Ọ na-abawanye mmepụta nke ma fibronectin na glycosaminoglycans (dị ka hyaluronic acid), nke na-enyere akpụkpọ ahụ aka inwekwu mmiri, na-akwalite ọrụ mgbochi, ma na-ebelata omimi nke wrinkle.

Data arụmọrụ gbasara Tetrapeptide-4 dabere na in-vitro ma ọ bụ obere ọmụmụ mmadụ nyere ndị na-ebubata ya..

N'ime ndị a, Otu ọmụmụ nke ọtụtụ isi mmalite na-ezokarị aka na-enye ihe akaebe izizi izizi.

Na nyocha ụlọ ọgwụ, 28 ụmụ nwanyị ndị ọrụ afọ ofufo mere agadi 44-66 tinye ude mgbochi nke nwere 60 Tetrapeptide-4.

Ndị mmadụ na-eji ngwaahịa a otu ugboro kwa ụbọchị maka 8 izu.

Ejiri ngwa ọrụ pụrụ iche na nyocha ihu ihu gbakọọ omimi nke wrinkles.

Nsonaazụ gosipụtara dị ịrịba ama (p<0.05) mbelata na omimi nke nhụsianya periorbital na ụkwụ kwakwa mgbe etinyere ude tetrapeptide-4 ma e jiri ya tụnyere ya. ndabere.

Nkwụsi ike na nhịahụ nke akpụkpọ ihu ka agbalitere nke ọma n'enweghị akụkọ banyere mmetụta na-adịghị mma.

Ọmụmụ ihe a na-enye ihe akaebe na-akwado mmezi akpụkpọ anụ na mgbochi ịka nká nke tetrapeptide-4.

A na-eji Tetrapeptide-4 eme ihe n'ụdị ngwaahịa nlekọta anụ ahụ niile na-egbochi ịka nká sitere na serum na ude ihu ruo ude anya na ude olu..

Ọ na-ebelata omimi na olu nke wrinkles static na ike, kpọmkwem nasolabial folds na ukwu ukwa.

N'otu oge ahụ, ọ na-enyere aka ịkọwa ahịrị agba, adres na-ada, ma mee ka akpụkpọ anụ lax sie ike n'ihi mfu collagen mgbe ịka nká.