Caprooyl tetrapeptide-3 (Caprooyl-Gly-His-Lys-Lys) bụ ike ihe na-eto eto mimetik, ọtụtụ tinye n'ọrụ na ịchọ mma ngwaahịa maka mgbochi wrinkle, ikwado, nrụzi ịwa ahụ gasịrị, na mgbochi ịgbatị akara.
Ọ na-eguzo dị ka otu n'ime ndị na-adịghị ahụkebe MMIRI (Dermal-Epidermal Junction)-ezubere iche peptides n'ime ngwa agha mgbochi ịka nká ugbu a na-ejikọta ọrụ dị elu, pụrụiche kwụsie ike, na obere iwe.
A na-emepụta peptide a site na simulation na njikarịcha nke GHK, Iberibe ọgwụgwọ ọnya sitere na Ihe na-agbanwe Uto. Ezie na eke GHK upregulates njikọ na ebighị nke Collagen VII, Lamini-5, na Fibronectin, Ngwa ọgwụgwọ ya na-ejedebe site na obere ọkara ndụ plasma na njigide akpụkpọ ahụ adịghị mma.
N-terminal ε-amino hexanoic acid acylation pụrụ iche na caprooyl tetrapeptide-3 na-eme ka ndakọrịta ya na mmadụ. stratum corneum lipids site na okpukpu isii, na-akwalite okwu protein isi nke ọma, na-abawanye permeability anụ ahụ site na okpukpu anọ, na n'ụzọ pụtara ìhè mma ndu ntụgharị mgbaàmà, si otú a na-emeri njedebe ebumpụta ụwa nke GHK eke dị ka onye na-arụsi ọrụ ike.
Nke biomimetic, Usoro ntughari nke caprooyl tetrapeptide-3 emeela ka a nabata ya n'ọtụtụ ihe ịchọ mma dị elu ma mee ka ọganihu dịwanye elu na nyocha ọganihu wrinkle.1
Usoro
Caprooyl-Gly-His-Lys-Lys
Nọmba CAS
1012317-71-3
Usoro ihe omimi
C32H59N9O11
Ibu molekụla
745.86
Caprooyl Tetrapeptide-3 Nnyocha metụtara
1.Usoro isi na nrụpụta ọtụtụ akụkụ
Ọzọkwa, Ọdịdị biomimetic ya pụrụ iche na-enyere ọtụtụ ezubere iche aka, synergistic mgbochi ịka nká na ịchọ mma uru. Ọ na-ejigide ọrụ bụ isi nke peptide GHK-Cu endogenous, na-akpali njikọ na mgbakọ nke Ụdị I, III, na IV collagen yana fibronectin, ebe n'otu oge na-egbochi oke okwu nke matrix metalloproteinase.
Nke a na-eduga n'ọganihu dị ịrịba ama na ọnọdụ akpụkpọ ahụ ma na-akwalite ọdịdị ntorobịa na-adịgide adịgide. Na mgbakwunye, ọ upregulates njikọ nke okpuru ulo akpụkpọ ahụ protein mpaghara, na-ewusi nkwụsi ike DEJ ike na ịkwalite nkwụsi ike anụ ahụ na ndidi.
2.Nkwalite nke Ọrụ Synthesis Collagen
Caprooyl tetrapeptide-3 na-ejigide usoro nke peptide GHK endogenous., na-ekwe ka ọ rụọ ọrụ nke ọma chelate ọla kọpa ion (Ku²⁺) ma na-etolite ogige ndị na-arụ ọrụ n'ime ahụ.
Nke a, n'oge ya, na-akwalite ọrụ ederede nke mkpụrụ ndụ ihe nketa metụtara collagen n'ime sel, na-akpali njikọ nke Ụdị I na Ụdị III collagen.
Ọ nwere ike ịbawanye njupụta nke collagen na oke na dermis, imeziwanye njupụta anụ ahụ na ibelata ahịrị dị mma na wrinkles nke mfu collagen kpatara.
Na omume ụlọ ọgwụ, egosila na iji caprooyl tetrapeptide-3 eme ihe ogologo oge ka ọ na-emeziwanye wrinkles static dị ka mpịaji nasolabial na ụkwụ crow.2
3.Mgbochi nke Matrix Metalloproteinase rụọ ọrụ nke ukwuu
Caprooyl tetrapeptide-3 na-egbochi oke mmechi nke matrix metalloproteinases nke nrụgide na-akpata dị ka ikpughe UV..
N'ọkwa mkpụrụ ndụ ihe nketa, ọ na-egbochi ụzọ ntụgharị mgbaàmà nkịtị, iwetulata njikọ na ịgbalite interstitial collagenase na gelatinase.
Nke a na-enye nchebe kachasị maka iguzosi ike n'ezi ihe na nkwụsi ike nke akpụkpọ ahụ dị ugbu a extracellular matriks nhazi, si otú ahụ na-agbatị oge ọdịdị akpụkpọ ahụ ntorobịa na-ebelata nke ọma na usoro ịka nká akpụkpọ ahụ n'ime ndị tozuru okè. 3
4.Ịmesi ike nke njikọ cell Dermal-Epidermal na ọrụ mgbochi
Caprooyl tetrapeptide-3 na-akwalite njikọ na ịgbalite ụdị collagen IV., lamini, na ụdị XVII collagen.
Nke a na-ewusi njikọ dermal-epidermal ike, na-eme ka mmepụta ihe na-edozi ahụ dịkwuo mma n'etiti sel dermal na epidermal, ma na-akwalite njikọ intercellular siri ike karị.
N'ihi ya, ọ na-eme ka usoro nkwado dị n'ime anụ ahụ dịkwuo mma, na-eme ka a zuo oke, udidi ọzọ resilient.
N'ozuzu, ọ na-eme ka ọrụ mgbochi akpụkpọ ahụ dịkwuo elu, ebelata mmiri ọnwụ, ma na-eme ka nnabata akpụkpọ ahụ dịkwuo mma.
COA
HPLC
MS
