Dipeptide - 2

Nnyocha nke Dipeptide-2

N'ime sayensị ịchọ mma, A na-ekewa Dipeptide-2 dị ka peptide bioactive nwere ikike mgbochi ịka nká. Nlekọta akpụkpọ ahụ na-egbochi ịka nká akwalitela peptides bioactive n'ihu na mmepe ọgbara ọhụrụ; obere arọ molekụla, ike (ruo n'ókè ụfọdụ) ike ezubere iche, na dịtụ mma akpụkpọ permeability niile na-eme ka ha ewu ewu. Isi bioactivity nke dipeptide-2 n'onwe ya sitere Angiotensin na-agbanwe enzyme (ACE) na-egbochi ihe onwunwe. Nke a na-etolite usoro usoro mmụta zuru oke nso maka nrụpụta ịchọ mma ọ bụla nwere ike igosi, mgbasa metụtara akpụkpọ nchegbu ịbụ otu n'ime ndị ọzọ kpọmkwem ngwa.

Enzyme na-agbanwe Angiotensin (ACE) bụ isi zinc metallopeptidase; na-eme ka mgbanwe nke Angiotensin I banye na vasoconstrictor dị ike Angiotensin II (Ọ bụ sistemụ renin-angiotensin na-ahụ maka usoro a). Angiotensin II dị ka e kwuru, na-akpata vasoconstriction, ọbara mgbali elu, enwere ike ijide mmiri.

A 2015 ọmụmụ ihe nke ọma dịpụrụ adịpụ dipeptide-2 site na azụ mmiri miri emi protein hydrolyzate, na-akwado ikike inhibitory ACE ya – Akọrọ ọnụ ahịa IC50, dị ala iji gosi ike in vitro ọrụ. Ihe akaebe doro anya na in vitro nke mgbochi ACE dị.

Na-akwado ọrụ metụtara ACE dị n'elu, Otu ihe ọmụmụ ahụ rụkwara aka na njirimara antioxidant ya. Nchegbu oxidative bụ ụdị mbụ nke ịka nká akpụkpọ ahụ; ụdị ikuku oxygen na-emebiga ihe ókè na-emebi akụkụ sel niile (DNA, protein, lipids) ma mee ka enzymes na-emebi emebi nke matrix extracellular. Val-Trp, ọbụlagodi na akụkụ, na-echebe mkpụrụ ndụ akpụkpọ ahụ site na ụdị mmebi a – free radical ụdị mgbochi ịka nká mmetụta bụ ihe bara uru usoro nkwado ya ndị ọzọ (na akwụkwọ nke ọma) uru.

Site n'igbochi ọrụ ACE nke ọma, Dipepetide-2 na-ebelata mmepụta nke angiotensin II. Vasoconstriction na edema mpaghara na-esote na-ebelata ozugbo site na mbelata a.

Usoro a dị mkpa karịsịa na nlekọta anụ ahụ; Mgbochi ACE na-ebelata ikike nke capillary, igbochi ụfọdụ ụdị nchịkọta mmiri. Mmụba nke lymphatic dị mma bụ isi ihe ga-esi na usoro a pụta, na periorbital puffiness na ụdị hyperpigmentation dị iche iche na-ebelata nke ọma. Mmụba microcirculation n'onwe ya na-eweta oxygen ka mma yana inyefe nri n'ozuzu ya na anụ ahụ anụ ahụ – ahụ ike cellular na nso ume ike mgbe niile bụ nsonaazụ njedebe.

Na-ekwu na dipeptide-2 (n'ọnọdụ nlekọta anya) nwere ike 'iwepụ akpa anya, okirikiri gbara ọchịchịrị, na edema metụtara ya’ bụ ezigbo ntọala ojiji nke usoro echiche a.

Dipeptide-2 bụ ihe a na-ahụkarị n'ime nlekọta anụ ahụ na-egbochi ịka nká, ude anya bụ isi ihe atụ. Edema n'oge na opekata mpe akụkụ ụfọdụ nke okirikiri gbara ọchịchịrị na-ebelata nke ọma site na ya. Na-eme ka ihe mgbochi akpụkpọ ahụ dị ike na hydration niile gburugburu na-agbakwunyere, uru kọrọ nke ọma.

Ọmụmụ ụlọ ọgwụ na-akwado nkwalite niile a kpọtụrụ aha n'elu; nkwụsi ike na nchapụta bụ isi njedebe nke ịdị irè ọgwụgwọ.