Dipeptide-6 is a dipeptide formed through a peptide bond linking proline (Pro) na hydroxyproline (Hyp). Considered one of the primary characteristic peptide fragments produced during the digestion and subsequent breakdown of collagen within the human body, it serves as a near-constant biomarker of collagen metabolism. Hydroxyproline itself is an amino acid unique to collagen; the stability and various forms of biological activity associated with this dipeptide depend heavily on its presence – maintaining at least partial structural integrity of the skin being one such outcome.
Usoro
H-Pro-Hyp-OH
Nọmba CAS
18684-24-7
Usoro ihe omimi
C₁₀H₁₆N₂O₄
Ibu molekụla
228.25 g/mol
Research Of Dipeptide-6
Collagen is the primary structural protein found in most connective tissues (skin, bones, cartilage being prime examples). Characteristic repeating sequences (Gly-X-Y, X/Y ọzọ na-abụkarị Pro ma ọ bụ Hyp) nye anụ ahụ ndị a ike nhịahụ ha chọrọ na ike ọrụ gburugburu. Hydroxyproline dị ka ekwuru bụ nke na-akọwa amino acid, ọdịnaya ya dị nso na-egosipụta ọnọdụ metabolic nke anụ ahụ ugbu a gbasara collagen.
Hydroxyproline nwere akụkụ peptide bụ isi akụkụ bioactive nke peptide ọ bụla enwetara collagen. – Pro-Hyp na ụdị ndị emetụtara na-edepụta nke ọma. Nlekọta ọnụ na-enye ohere maka ọkwa ụfọdụ nke nnabata, ịbanye n'ọbara ka ọ dịkarịa ala na-ahazi ọrụ fibroblast akpụkpọ anụ.
Dipeptide-6 bụ peptide sitere n'okike, sitere na collagen kwuru. Collagen sitere na anụmanụ (akpụkpọ anụ, anụ wdg.) na-enweta ma mmadụ ma ụlọ ọrụ mgbaze /hydrolysis; agbụ ogologo na-agbaji n'ime obere peptides, H-Pro-Hyp-OH bụ otu n'ime ngwaahịa ngwụcha bioactive na-achọpụta ngwa ngwa.
Nnyocha n'ime usoro ya na-arụtụ aka ugbu a maka mmetụta mgbochi ịka nká nke dipeptide-6 dị ka ihe jikọrọ ya na mkpali nke mmụba na ọrụ fibroblast..
Na-akwalite Mgbasa Fibroblast na Collagen Synthesis: Fibroblasts bụ ụlọ ọrụ izizi’ na-ahụ maka synthesizing akpụkpọ scaffolding na hydrating components; collagen, elastin, na hyaluronic acid bụ ihe atụ kachasị edekọ nke ọma. Ọrụ ha na-arụ ọrụ na-agbadata nke ukwuu ma afọ.
Ọtụtụ ọmụmụ in vitro na-egosi mgbe niile na Dipeptide-6 na-arụ ọrụ nke ọma fibroblast proliferation na njem na-esote.. Nnyocha na-ezo aka kpọmkwem na Dipeptide-6 na-akpali mmụba na uto a – òké na anụ ahụ fibroblasts ma na-azaghachi ya.
A na-ahụkwa akụkụ chemotactic, fibroblasts na-adọrọ mmasị ịkwaga n'akụkụ ụfọdụ; mmezi nke mmebi akpụkpọ ahụ na ụdị dị iche iche nke imegharị anụ ahụ na-adabere na usoro a.
E gosipụtara Dipeptide-6 iji kwalite ọrụ hyaluronic acid synthase n'ime fibroblasts. Kpọmkwem metụtara nke dị n'elu, mma akpụkpọ hydration (onye plumper, nso-igirigi ọdịdị) nsonaazụ sitere na mmepụta ụbara.
Nke enweghị usoro, kpuo ìsì abụọ, Nnwale ụlọ ọgwụ na-achịkwa placebo site na iji usoro mkpokọta peptide nke nwere mkpokọta mkpokọta nwere Pro-Hyp gosipụtara mmụba na hydration akpụkpọ ihu., elasticity, wrinkles na metrics metrics gafere 8 izu.
Na-akwalite mmeghari na imeghari ECM: Na-arụ ọrụ fibroblasts dị ka ekwuru n'elu, Ntugharị ECM na-apụtaghị ìhè bụ isi ihe pụta. Mmezi nke protein ECM akọwapụtara (ụdị m collagen bụ isi ihe atụ, along with elastin and fibronectin) at the genetic level has been reported.
Inhibition of Matrix Metalloproteinase-1 (MMP-1) Nkwuputa: Oral supplementation of collagen peptides leads to increased plasma levels of Gly-Pro and all related dipeptides; reducing UVB induced MMP-1 is one of the more measurable end points of this pathway.
Dipeptide-6, in all its forms, is a true multi-faceted regulator of skin physiology. Facial aging is only one of many potential benefits of Pro-Hyp or similar dipeptides.
COA
HPLC
MS
