Delta peptide na-ebute ụra (DSIP) bụ ihe na-arụ ọrụ ndụ neuropeptide mejupụtara amino acid itoolu. Nchọpụta nke DSIP nọchitere anya ngbanwe na nghọta nke ụkpụrụ ihi ụra - site na nlegharị anya gara aga nke etiti etiti etiti etiti na-achịkwa ụra n'otu akụkụ ruo n'ịmata ọrụ nke ndị na-ahụ maka ụra na-arụ..
Nke a peptide na-egosipụta ọrụ physiological sara mbara yana usoro omume dị iche iche. Ike ya iji gafee ngwa ngwa mgbochi ụbụrụ ọbara(BBB) bụ otu n'ime ihe ndị a ma ama; òkè ya n'ịchịkwa ihe hypothalamic-pituitary-adrenal (HPA) axis na mmetụta na sistem homeostasis niile bụ ihe ndekọ nke ọma.
N'ofe isi ọrụ na-achịkwa ụra (nkwalite ụra miri emi, mma ụra ije, na nkwalite ogo ihi ụra), DSIP na-egosiputa neuroprotective siri ike na, ruo n'ókè dị ịrịba ama, ikike mmezi. Ịkwalite nguzogide neuronal n'ụdị dị iche iche nke imebiga ihe ókè bụ isi ihe atụ nke a.
Usoro endocrine na thermoregulation bụkwa nke hiwere ọrụ DSIP. Na nso nso a, antioxidant na detoxification ahụrụla ihe omume.
Usoro
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
Nọmba CAS
62568-57-4
Usoro ihe omimi
C35H48N10O15
Ibu molekụla
848.33
Nnyocha nke Delta ụra na-ebute peptide (DSIP)
1.Mmetụta Na-ebute Ụra
Usoro ihi ụra bụ isi ọrụ nke DSIP na-ejikọkarị ya. A dị ike na nhọrọ nkwalite nke ụra nwayo bụ mmetụta ya na-akọkarị. Ihe enyemaka ụra nke exogenous na-arụ ọrụ site na usoro dị iche iche kpamkpam; DSIP, dị ka peptide neuroregulatory endogenous, physiologically modulates (n'ụzọ nke ọma) ihe owuwu ihi ụra nke onye ọrụ. Ịbawanye ogologo oge nke ụra miri emi bụ njikọ aka kpọmkwem nke mma ihi ụra.
Ọmụmụ ihe metụtara 400 ndị ọrịa na-ata ahụhụ siri ike ehighi ura, onye natara injections DSIP na-aga n'ihu ruo otu izu, gosiri mmụba dị ịrịba ama n'akụkụ niile atụnyere ogo ụra. Ndị ọrịa nwere mgbakasị neurotic, ọ kachasị, gosiri mmụba dị ịrịba ama na ngbanwe maka mkpali mpụga mgbe ịgbanye ọgwụ mgbochi.
Nsonaazụ ndị a na-emesi ike ọrụ dị ike nke DSIP na nhazi ihi ụra na ike ya n'ịgwọ ọrịa akwara ozi.
2.Iwu Ọnọdụ okpomọkụ nke ahụ na moto
Ụfọdụ ọgwụ na-eme ka ụbụrụ dopamine dịkwuo mma nwere ike ịgbanwe okpomọkụ ahụ. DSIP na-emekọrịta ihe na ọgwụ ndị a, na-ebute mgbanwe ndị ahụ e kwuru n'elu.
Nnyocha e mere na ụmụ oke gosiri na DSIP dị ntakịrị ma ọ bụ nke na-agafeghị oke na-ebelata ọrụ moto na okpomọkụ ahụ n'okpuru ọnọdụ 4 Celsius..
Mgbe eweghachiri ụmụ oke na gburugburu 22°C, Ejikọtara nchịkwa DSIP na mmụba nke okpomọkụ ahụ.
3.Endocrine Regulatory Ọrụ
Axis HPA bụ isi usoro neuroendocrine maka nzaghachi nrụgide ahụ.
Imebiga ihe ókè nke usoro a na-eduga na-adịghị mma, ọkwa cortisol dị elu na-adịghị ala ala. DSIP na-egbochi mmetụta a site na igbochi CRH na ACTH ntọhapụ.
4.Ọrụ Neuroprotective na Mmezi
DSIP egosipụtala ihe ndị na-ahụ maka akwara ozi na nrụzi nke na-anọchite anya akụkụ dị mkpa nke ike ọgwụgwọ ya..
Ọ na-egosi nkwa maka ọgwụgwọ nke ọrịa neurodegenerative , n'etiti ọnọdụ ndị ọzọ.
COA
HPLC
MS
