Hexapeptide-11 bụ peptide bioactive nke dịpụrụ adịpụ na Saccharomyces ferment.. A na-ahazi ụdị dị ọcha ugbu a n'ihi nchegbu ịdị ọcha dị iche iche. Na-achịkwa usoro ịka nká cellular, na-akwalite extracellular matriks njikọ, na ịkwalite ọrụ mgbochi akpụkpọ ahụ bụ ngwa niile nwere ike ime; Ihe ịchọ mma na-egbochi ịka nká na nrụzi akpụkpọ ahụ bụ nke a kacha mara nke ọma.
Usoro
Phe-Val-Ala-Pro-Phe-Pro
Nọmba CAS
161258-30-6
Usoro ihe omimi
C36H48N6O7
Ibu molekụla
676.8 g/mol
Nnyocha nke Hexapeptide-11
Dị ka ihe mgbochi ịka nká dị irè, Ọrụ bụ isi nke Hexapeptide-11 bụ itinye aka na nhazi usoro ịka nká nke mkpụrụ ndụ akpụkpọ ahụ. – dermal fibroblasts ma ọ bụrụ na m chetara nke ọma. A mgbagwoju, nso usoro ihe omume nwere ọtụtụ akụkụ bụ maka nke a; netwọkụ protein homeostasis bụ isi, mkpochapụ nke ịka nká na-ebute ụzọ (nrụgide oxidative bụ isi ihe atụ), na n'ụzọ dị ukwuu n'ịkwalite okwu mkpụrụ ndụ ECM dị mkpa.
Hexapeptide-11 n'onwe ya na-eweghachi nke a protein homeostasis; na-arụ ọrụ usoro proteasome, ụdị dị iche iche nke autophagy, na mgbanwe chaperone a kapịrị ọnụ niile na-ekere òkè. Na-eme ihe dị ka onye na-akpata nrụgide dị ala’ (ụdị hormetin) ọ na-edozi mkpụrụ ndụ ahụ, mkpali mpụga dị nro na-eduga na ịgbalite okirikiri niile nke opekata mpe nchekwa nwa oge na ụdị nrụzi.
Nkwado “nrụgide akpatara akaghi aka senescence” bụ otu n'ime mmetụta ya egosipụtara nke ọma. Selụ sesenescent ebulila nke ọma Senescence metụtara beta-galactosidase (SA-β-gal ma ọ bụ SABG) ọrụ dị ka akara ngosi zuru ụwa ọnụ nso.
Ọrụ in vitro na-eji fibroblasts dermal mmadụ ekpughere na oxidants (Hydrogen peroxide/H₂O₂ ịbụ kpochapụwo ikpe) na-egosi nkwụsịtụ zuru oke nke mmụba a na-atụ anya na SA-β-Gal, igbu oge nke afọ ndụ bụ nsonaazụ doro anya.
Nyocha ọkwa mkpụrụ ndụ ihe nketa na-akwado nkwalite metụtara ECM nke a kpọtụrụ aha n'elu, na mmetụta ọkwa ọkwa niile anyị na-ahụ na ụlọ ọgwụ, bụ n'ọkwa dị ukwuu, nsonaazụ mgbanwe ọkwa ekwentị ndị a.
Oriri oxygen na ọrụ metabolic na-abawanye, ihe nrịbama ọzọ dị mma nke ọrụ cellular ka mma.
Ọmụmụ ihe na-achịkwa placebo gụnyere 25 Ndị ọrụ afọ ofufo ahụ siri ike gosipụtara na isiokwu ndị na-etinye usoro hexapeptide-11 kpọmkwem ugboro abụọ kwa ụbọchị maka izu anọ gosipụtara mmụba dị ịrịba ama na ngbanwe akpụkpọ ahụ mbụ na ụdị nzaghachi nrụrụ.; otu placebo jere ozi dị ka ebe ntụnyere kpọmkwem.
Ihe ọzọ yiri na vivo ọmụmụ, ya na 25 ndị ọrụ afọ ofufo, nyochara serum siri ike nwere hexapeptide a kpọtụrụ aha na a 2.8% (v/v) itinye uche. Nleta akụrụngwa mgbe oge izu anọ nke ngwa gachara gosipụtara nkwalite doro anya n'ihe enwere ike ịkọwapụta n'ụzọ ole na ole dị ka nkwụsi ike anụ ahụ..
A na-etinye Hexapeptide-11 ugbu a n'ọtụtụ usoro mgbochi ịka nká, wrinkles bụ isi nchegbu a ga-ebelata. Akpụkpọ ahụ siri ike (ruo n'ókè ụfọdụ) bụ a chọrọ ọgwụgwụ n'ihi.
Nnukwu ọnụ ọgụgụ, A ka na-achọrọ ọmụmụ ụlọ ọgwụ emebere nke ọma iji kwado nrụpụta ọrụ niile nke a na peptides metụtara.
COA
HPLC
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