Hexapeptide-9 (Hexapeptide-9, aha ahia Collaxyl™) bụ peptide sịntetik bioactive mebere nke amino acid isii akọwapụtara. A na-ahụ nhazi nke peptide a n'ime mmadụ collagen IV na XVII; ndị a na-ejikọta ya na ihe ndị bụ isi nke akpụkpọ anụ okpuru ulo. Achịkọtara na teknụzụ biotechnological iji ṅomie ụfọdụ, ọ bụrụ na ọ bụghị ihe niile, ọrụ nke eke collagen, ịdị ọcha na nkwụsi ike okwu pụta ụwa ọzọ 'omenala’ eke extracts na-ekpochapụ. Nkwụsi ike dị elu na nhazi dị mfe emeela ka ọ dị nso n'ụwa niile na ngwaahịa nlekọta anụ ahụ dị iche iche na-egbochi ịka nká.
Usoro
Gly-Pro-Gln-Gly-Pro-Gln
Nọmba CAS
1228371-11-6
Usoro ihe omimi
C₂₄H₃₈N₈O₉
Ibu molekụla
582.28 g/mol
Nnyocha nke Hexapeptide-9
A na-edekọ usoro omume ọtụtụ akụkụ maka Hexapeptide-9. A na-eji ụdị izizi nke ndu ozi eme ihe – na-arụ ọrụ na emesịa na-achịkwa njikọ dị n'ime akpụkpọ ahụ na ụzọ nrụzi.
Na-akwalite Synthesis Collagen: Mkpali ozugbo nke fibroblasts dermal bụ otu usoro dị otú ahụ; mmụba mmepụta nke ma Ụdị I na Ụdị IV collagen bụ njedebe ikpeazụ. Ụdị nke Mbụ na-eje ozi dị ka nkwado nhazi oge niile dị nso na dermis, resilience ịbụ kpọmkwem byproduct. Ụdị IV ('baby collagen’ ọ bụrụ na ị ga-) na-ejikọta elasticity na ire ụtọ n'ozuzu ya na akpụkpọ ahụ.
Mbuli elu nke collagens abụọ a n'otu oge na-eduga n'ịhazigharị nke ọma nke ihe owuwu dermal dị n'okpuru., na-ebelata ịdị omimi nke wrinkle na nkwalite niile gburugburu na nkwụsi ike.
Na-ewusi ike Njikọ nke Dermal-Epidermal Junction(MMIRI): Nke a bụ ebe Hexapeptide-9 kewapụrụ onwe ya n'ezie. Ụlọ ọrụ DEJ (ọzọ, akwa anụ ahụ) na-opekata mpe, weghachiri eweghachi ya. Laminin-5 na Ụdị IV collagen synthesis n'ime mpaghara a bụ ihe na-eme ka Hexapeptide-9 bara uru nye onye ọrụ njedebe..
Nyefe nri, iguzosi ike n'ezi ihe na ihe niile na-esote, bụ ọgụ mgbe niile megide oge na sagging.
Na-eme ka mgbochi akpụkpọ ahụ na hydration dịkwuo mma: N'ofè ya dermal omume, Hexapeptide-9 na-eme ka usoro nrụzi epidermal dịkwuo elu. Iweghachi akpụkpọ ahụ mebiri emebi (akara mgbe ihe otutu, ụdị dị iche iche nke scratches, ma ọ bụ ọbụna ụfọdụ mmetụta usoro post-aesthetic) bụ otu n'ime ngwa ya bara uru karị.
Ihe omumu ihe omumu in vitro gosiputara kpomkwem ngbanwe nke filaggrin (FLG) mkpụrụ ndụ ihe nketa; ọdịiche nke epidermal na arụ ọrụ mgbochi na-adabere kpamkpam na protein a. Filaggrin n'onwe ya bụ ihe mmalite maka ihe a maara dị ka ihe ndị na-eme ka mmiri dị n'okike – ụbara ọnụnọ nke na-egosi kpọmkwem nke hydration anụ ahụ dị mkpụmkpụ na ogologo oge, ebe njedebe zuru oke dị nso nke mgbochi mgbochi.
Ọmụmụ ụlọ ọgwụ egosila mmụba na mmepụta collagen n'ozuzu ya (ruo 117% ọ bụrụ na m echeta nke ọma) yana nkwalite ndị ọzọ dị aghụghọ mana enwere ike ịtụtu ya na elasticity.
Ọzọkwa, Nchọpụta na-arụtụ aka ugbu a na hexapeptide-9 cyclic (CHP-9) dị ka ihe nwere ike elu mgbochi ịka nká ngwọta. Omenala peptides linear nwere ebe ha, ma usoro cyclic na-enye nkwụsi ike ka ukwuu, enwekwukwa bioavailability na ọrụ physiological gburugburu.
Ngwa ngwa nke ụdị ụfọdụ nke peptide cyclic a bụ usoro echiche na-ekwe nkwa igbochi ma ọ bụ opekata mpe, belata ịka nká akpụkpọ ahụ.. Ikwenye uru niile a kpọtụrụ aha n'elu site na ọmụmụ ihe na-achịkwa nke ọma bụ nzọụkwụ ezi uche na-esote.
COA
HPLC
MS
