LL-37 bụ otu antimicrobial peptide site na kathelicidin ezinụlọ. Aha n'onwe ya na-ezo aka na ya 37 amino acid mejupụtara na N-terminal mmalite nke abụọ leucine foduru. HCAP18, naanị onye so na ezinụlọ cathelicidin mmadụ, Ndị mmadụ na-enweta mgbawa kpọmkwem iji wepụta iberibe LL-37 a na-arụ ọrụ ndụ..
Nchọpụta nke LL-37 gosipụtara mgbanwe mgbanwe nke cathelicidin site na ụdị anụmanụ gaa na mmadụ. Dị ka akụkụ dị oke mkpa nke usoro ahụ ji alụso ọrịa ọgụ, LL-37 na-arụ ọrụ dị mkpa n'ichebe mmadụ megide nje.
Ọrụ bụ isi nke nchekwa a bụ ọrụ nje bacteria sara mbara nke ukwuu. The amphipathic α-helical(Alfa helix) Ọdịdị nke na-ahụ maka ọrụ a na-akpali mmasị electrostatic n'ebe akpụkpọ ahụ nje na-adịghị mma. Nkwụsị ozugbo nke iguzosi ike n'ezi akpụkpọ ahụ na-eduga na mfu nke nri intracellular; Ọnwụ nje bacteria na-esote. Karịsịa, usoro a anaghị ebute ụdị nguzogide ọ bụla.
A na-ekwukwa na ọ bụ ya kpatara ọrụ ndị ọzọ dị n'ime ahụ – ọgwụgwọ ọnya, mmezi anụ ahụ, ike immunomodulation, endotoxin neutralization, ma gosipụta ọgwụ mgbochi ọrịa cancer na mgbochi nje.
Usoro
Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Glu-AV-Asn
Nọmba CAS
154947-66-7
Usoro ihe omimi
C205H340N60O53
Ibu molekụla
4493.34
Nchọpụta LL-37 metụtara
1.Arụmọrụ mgbochi nje Broad-Spectrum Direct
Ngwa ngwa na kpọmkwem bactericidal edinam megide a dịgasị iche iche nke microorganisms bụ ọrụ LL-37 edekọ nke ọma. Gram adịghị mma, nti, na ọbụna ụfọdụ fungal pathogens na-niile nke ọma gburu.
Ihe cationic, Njirimara amphipathic nke peptide bụ isi ihe na usoro a; Akụkụ ndị ebubo na-ejikọta ozugbo na akpụkpọ ahụ nje bacteria. Mwepu nke ọdịnaya cellular na ndakpọ nke ike akpụkpọ ahụ bụ nsonaazụ njedebe nke mwakpo ahụ.
Omenala ọgwụ nje na-arụ ọrụ site nnọọ iche (na-abụkarị ebumnuche-kpọmkwem) ụzọ mgbochi; Ụdị ọgụ nke LL-37 bụ ma ngwa ngwa na, ruo taa, ejikọtaghị ya na mmepe nguzogide dị ịrịba ama. Ọmụmụ ụlọ ọgwụ mmadụ na-akwado nchekwa na ịdị irè nke LL-37 dị ka onye na-ahụ maka ọgwụgwọ.
2.Ọrụ Immunomodulatory dị ike
LL-37 na-arụ ọrụ ya dabere na microenvironment mpaghara n'ime ahụ. Mgbe achọpụtara mmerụ anụ ahụ ma ọ bụ mgbanwe pathological, LL-37 na-arụ ọrụ dị iche iche na-achịkwa ihe na sel iji chịkọta na saịtị ndị a.
Mgbanwe nke mwepụta cytokine mkpali bụ otu n'ime ụzọ ya bụ isi; A na-agbada n'ụzọ dị ukwuu nzaghachi pro-inflammatory kpọmkwem. Na-akwalite cell dendritic(DC) maturation na ụdi T cell iche bụ isi ihe ọzọ na usoro a – na-anọchite anya àkwà mmiri dị mkpa n'etiti ihe mgbochi ebumpụta ụwa na nke na-agbanwe agbanwe.
3.Na-akwalite ọgwụgwọ ọnya na mmezi anụ ahụ
Ọgwụgwọ ọnya LL-37 na ike nrụzi anụ ahụ jikọtara ya na ọrụ immunomodulatory ya, tinyere ọrụ antimicrobial kpọmkwem.
Ịgbalite ụzọ mgbochi nje na-ebute keratinocytes, fibroblasts, na sel endothelial ịkwaga na saịtị ọnya; mmụba cell na-esote ka a na-edozi mmebi. Angiogenesis na-enye ma ume na nnyefe nri na anụ ahụ merụrụ ahụ.
4.Ọrụ mgbochi ọrịa kansa
Selụ ọrịa kansa na-ekekọrịtakarị njirimara nke ikpughe ebubo na-adịghị mma phosphatidylserine na mpụta ha (sel nkịtị nwere nhazi ime nke ndị a phospholipids). Ụgwọ dị mma nke LL-37 na-adọrọ mmasị ha.
Apoptosis na necrotic ụzọ ọnwụ nke yiri nke a na-eji megide nje bacteria na-amalite mgbe ahụ. Indirect mgbochi tumor mmetụta site na mgbochi mgbochi ọrịa na-ekerekwa òkè.
Ọmụmụ ihe izizi egosila mbelata nke ọma na mkpụrụ ndụ kansa nke ejiri LL-37 gwọọ ya; ọgwụgwọ anticancer na-eji LL-37 bụ mpaghara nyocha na-ekwe nkwa.
COA
HPLC
MS
