Myristoyl Hexapeptide-16 bụ ihe sịntetik lipopeptides. sịntetịtically, A na-emepụta ya site na ijikọ myristoyl n'ime N-terminus Hexapeptide-16.
Na-esite na alkaline zoro ezo na okike keratin-peptide jikọtara n'ime ntutu isi, peptide eke n'onwe ya nwere oge njigide akpụkpọ ahụ dị mkpụmkpụ yana ntinye akpụkpọ anụ adịghị mma – mmachi ekwuru site na mgbanwe lipid.
Ntinye nke myristoyl otu na-enye a hydrophobic ọdụ nwere ike itinye n'ime ha abụọ akpụkpọ anụ cell na nke stratum corneum; budata enwekwukwa akpụkpọ ahụ permeability bụ kpọmkwem nsonaazụ.
Ojiji zuru oke na serum nku anya dị iche iche, ngwaahịa na-egbochi ntutu isi na ude mmezi mgbe ịwa ahụ gasịrị na-egosi uru ya. Profaịlụ ya dị ka onye na-achịkwa keratin dị nchebe (prostaglandin analogues bụ ntụnyere mbụ) bụ otu n'ime uru ya bụ isi.
Usoro
Myr-Leu-Lys-Lys-Ala-Leu-Lys-OH
Nọmba CAS
959610-54-9
Usoro ihe omimi
C47H91N9O8
Ibu molekụla
910.28
Nnyocha metụtara Myristoyl Hexapeptide-16
1.Ihe omume ndu ndu nke izizi:
A na-akwado nnyefe intracellular site na onye ogbugbo acid fatty acid endocytosis usoro; Mgbanwe nke ọnụahịa KRT1, Okwu mkpụrụ ndụ KRT5 na KRT14 na-akwalite keratin njikọ kpọmkwem na ntutu isi mkpụrụ ndụ, na-agbatị usoro anagen.
Ụyọkọ ụgwọ usoro lys-lys dị n'ime nhazi ya jikọtara ọnụ TGF-βR II, na-egbochi mgbama mgbanwe n'ebe catagen.
Nkwalite n'otu oge n'ogologo na njupụta nke nku anya na brow bụ nsonaazụ edepụtara.
AQP-3 na filaggrin A na-arụ ọrụ ntụgharị ederede, na-ewusi ike stratum corneum mgbochi hydration (ibelata mmiri transepidermal ọnwụ).
A na-emezi mmepụta nke ndị ogbugbo mkpali dị iche iche.
2.Ederede Keratin Gene
Akụkụ peptide bụ isi na-eṅomi ezinụlọ KAP5/8, na-ekekọta NF-κB-dị ka saịtị na mpaghara ndị na-akwalite mkpụrụ ndụ ihe nketa keratin.
Nke a na-amụba ngwa ngwa keratin njikọ na-eme ka ntutu isi kwụ ọtọ na ike.
3.Usoro Anagen gbatịrị agbatị
The peptide na-ebelata follicular regression nke ọma, na-ejigide steeti anagen.
A na-ahụkwa mmụba ma ogologo na njupụta nke nku anya na nku anya, mbelata ntutu isi bụ mmetụta ọzọ dị mkpa; A na-akwado uto ntutu na-adị ogologo oge.
4.Na-eme ka ihe mgbochi Stratum Corneum dị ike
Myristoyl Hexapeptide-16 na-ejikọta ya GPR40/FFA1 nnabata na keratinocyte elu, ịgbalite na Ụzọ cAMP/PKA, CREB (Ihe nzaghachi cAMP na-ejikọta protein) kpọmkwem ịbụ ihe mgbaru ọsọ mgbada; AQP-3 na transcription filaggrin na-esochi ya.
Mmụba ọdịnaya na-eme ka mmiri dị n'okike bụ nsonaazụ ozugbo, A na-enweta ọrụ hydration stratum corneum ka mma, ihe mgbochi akpụkpọ anụ kpụrụ – A na-ebelata oke mmiri transepidermal.
Mmanya moisturize anụ ahụ, emelitere ihe mgbochi iguzosi ike n'ezi ihe na mbelata nke nkụ na nkụchi obi; Ndozi akpụkpọ ahụ mebiri emebi dị n'ime oke ihe peptide a nwere ike nweta.
5.Mmetụta mgbochi mkpali na Antioxidant
Na-egbochi ụzọ mgbaàmà mkpali dị iche iche (NF-κB bụ ụzọ isi) bụ otu n'ime mmetụta ya guzosiri ike, na cytokines pro-inflammatory (IL-6, TNF-a n'etiti ndị ọzọ) na-ala na-achịkwa.
Akpụkpọ anụ uhie, Myristoyl Hexapeptide-16 na-ebelata mgbakasị ahụ na mgbaama akpụkpọ ahụ zuru oke.
COA
HPLC
MS
