Myristoyl Tetrapeptide-12 bụ peptide bioactive na-emepụta site na ijikọta otu myristoyl na usoro tetrapeptide akọwapụtara nke ọma.. Nhazi nhazi nke peptide a na-adọta mkpali kpọmkwem site na usoro nke myristoylation n'onwe ya – udi ngbanwe protin translational.
Mwelite sel akpụkpọ ahụ na ntụgharị mgbama na-esote bụ isi ihe si na mgbanwe nhazi a.; lipophilicity na nkwalite sel akpụkpọ ahụ permeability na-akakwa mma. Omume dị irè karị n'elu akpụkpọ na ntutu isi mkpụrụ ndụ bụ nsonaazụ ikpeazụ achọrọ.
Etinyela nlebara anya dị ukwuu maka iji ya eme ihe ịchọ mma na ụdị nlekọta anụ ahụ dị iche iche, akpọpụta mkpali uto ntutu bụ mmetụta kacha mụọ.
Usoro
Myr-Lys-Ala-Lys-Ala-NH2
Nọmba CAS
959610-24-3
Usoro ihe omimi
C32H63N7O5
Ibu molekụla
625.89 g/mol
Nnyocha nke Myristoyl Tetrapeptide-12
Myristoyl Tetrapeptide-12 dabara n'ụdị nke sịntetik na lipopeptides; nkwalite uto ntutu bụ isi (na edekọ nke ọma) a na-achọ ọrụ nwere ike ime.
Kacha guzosie ike na-egosi banyere a usoro nke ime ihe na-ezo aka ya ụkpụrụ nke ihe na-agbanwe uto uto (TGF-β)/Ụzọ Smad. Mmụba cell, iche, apoptosis, mmezi anụ ahụ – Ha niile bụ opekata mpe nke ụzọ a na-achịkwa ya, na ntutu follicle okirikiri abụghị ihe ọzọ.
Ụzọ nrịbama SMAD Nkwalite: Ịhazi ụzọ ahụ e kwuru n'elu bụ isi usoro. TGF-β n'onwe ya na-arụ ọrụ zuru oke na usoro niile a kpọtụrụ aha na mbụ.
Na-esote ọgwụgwọ na peptide, na-abawanye na phosphorylated SMAD2 (na oke SMAD3) a na-ahụ. Njikọ DNA kpọmkwem site na SMAD3 bụ nke ikpeazụ, nzọ ụkwụ siri ike na iwu ederede; enwekwukwa ikike njiko pụtara agbanwe (ruo n'ókè ụfọdụ) okwu mkpụrụ ndụ ala ala.
Ịrụ ọrụ SMAD2/3-DNA mmekọrịta bụ ihe peptide yiri ka ọ na-eme – Mmetụta uto ntutu nwere ike ịbụ nsonaazụ nke pụrụ iche a, ma ọ bụ opekata mpe akọwapụtara, usoro.
Usoro iwu cell stem folicle ntutu: Na-eṅomi (ma ọ bụ modulating) akụkụ dị iche iche nke ụzọ TGF-β zuru ezu, Tetrapeptide-12 na ngwaahịa njedebe ya nwere ike ime, n'akụkụ, wuliteghachi ịgba ígwè ito eto ntutu nkịtị.
Ọrụ ndị bụ isi nke ndụ Myristoyl Tetrapeptide-12 na-akwalite uto ntutu na ịhazi metabolism matrix cell..
Ugbu a, ojiji ya na-abụkarị n'ime usoro ịchọ mma; serum uto nku anya na ụdị dị iche iche nke ngwaahịa nlekọta ntutu bụ ihe atụ kachasị edekọ nke ọma.
Ọmụmụ ihe izizi egosila mmụba dị ukwuu nke njupụta nku anya, ogologo, na ọkpụrụkpụ dị ka kpọmkwem ihe si na peptide a pụta.
Usoro ndị nwere ya (Ọtụtụ mgbe na ngwakọta na peptides ndị ọzọ, Myristoyl pentapeptide-17 bụ ezigbo ihe atụ) rụọ ọrụ ntutu follicle keratinocytes, microcirculation mpaghara bụ ihe ọzọ emetụtara nke ọma – mma ‘ọdịdị’ nke lashes bụ njedebe ikpeazụ.
Ngwaahịa mgbochi ịka nká na-ejikwa peptide a, elasticity akpụkpọ na obere wrinkles na-opekata mpe ebelatara site na ya izugbe anụ ahụ usoro nhazi mmetụta..
COA
HPLC
MS
