Oligopeptides 24 bụ peptide sịntetik bioactive nke arụrụ ya nke ọma 13 amino acid foduru.
E sitere na mpempe enzymatically gbajiri elastin, o nwere ọrụ ndu pụrụ iche.
Nnụcha na-aga n'ihu, nyocha, na usoro njikarịcha ka etinyere ya iji kwalite ya transdermal ike absorption.
The ụma nsonye nke disulfide nkekọ na-arụ ọrụ iji mee ka usoro ya kwụsie ike.
Mgbanwe ndị a anaghị ebelata ọrụ ndu ya; n'ezie, A na-echekwa ọrụ bioactive protein eke eke.
Usoro
Cys-Met-Tyr-Ile-Glu-Gly-Gly-Gly-Gly-Arg-Gly-Asp-Gly
Nọmba CAS
1018685-16-9
Usoro ihe omimi
C50H78N16O19S2
Ibu molekụla
1271.39
Nnyocha metụtara Oligopeptide-24
1.Na-arụ ọrụ Elastin na-akwalite
Na-eṅomi ọrụ physiological nke elastin endogenous, ọ na-akwalite njikọ nke elastin n'ime ahụ dermis; akpụkpọ elasticity, iguzosi ike, na hydration niile na-akawanye mma.
Anụ ahụ gbadara agbagọ, smoothed mma ahịrị, na n'ozuzu nti mgbanwe na udidi bụ kpọmkwem nsonaazụ nke usoro a.
Direct mkpali nke fibroblasts (mmụba na ọrụ) na-eduga na ụbara njikọ nke collagen – ahụ ike , akpụkpọ ahụ na-eto eto karịa bụ nsonaazụ ikpeazụ.
Mgbe ịbanye na akpụkpọ ahụ site na usoro nnyefe, Oligopeptides 24 na-ejikọta na ndị na-anabata ya kpọmkwem n'elu fibroblast.
A na-eṅomi elastin nrịbama, a na-arụ ọrụ intracellular ụzọ; nke ederede nke mkpụrụ ndụ elastin n'onwe ya bụ isi ihe na-elekwasị anya.
A na-emewanye nkwụsi ike nke akpụkpọ ahụ na ịdị nro, na-akwụ ụgwọ maka ọdịda edere nke ọma (ịse foto) na-akpata mmepụta elastin eke.
Ọgbọ nke 'isi iyi’ protein bụ ihe na-eweghachi akpụkpọ ahụ merela agadi n'oge ntorobịa.
2.Na-arụ ọrụ Fibroblast ma na-akpali Synthesis Collagen
Dị ka e kwuru n'elu, Ezubere iche nke fibroblasts bụ otu n'ime mmetụta dị mkpa Oligopeptide 24 na-agba mbọ.
Ọ na-akwalite ọrụ metabolic nke fibroblasts, na-akpali nkewa na mmụba ha.
Ọ na-akwalite ịkwaga ngwa ngwa na mpaghara ndị mebiri emebi, na-eme ka ọnọdụ ọrụ ha dịkwuo mma na nhazi extracellular matriks na-akpali akpali mmepụta nke ọzọ Ụdị I na III collagen, na-eme ka usoro nkwụsi ike nke akpụkpọ ahụ dịkwuo ike.
A na-emeziwanye ike imezi onwe ya na akpụkpọ ahụ, na-eme ka ọdịdị ahụ dịkwuo mma.
3.Na-eme ka mgbochi akpụkpọ ahụ na arụ ọrụ hydration dị ike
Oligopeptides 24 na-arụ ọrụ integrin α6β4→PI3K→Akt axis, na-akpali akpali keratinocytes iji secrete filaggrin na loricrin, na ịkwalite okwu nke protein njikọ claudin-1 na occludin.
Nke a na-ewusi iguzosi ike n'ezi ihe n'etiti sel dermal na epidermal ike, na-eme ka ọrụ moisturize anụ ahụ dịkwuo elu, ma na-eme stratum corneum ọzọ emebibeghị.
4.Mmezi Antioxidant na Post-Procedure
Ihe fọdụrụ na Cysteine na-enye otu sulfhydryl ndị a na-emegharịgharị na-enye electrons na radicals efu., na-ewepụ ụdị oxygen na-emeghachi omume.
Site na ụzọ Nrf2/ARE, ọ na-akpali mmepụta nke ọtụtụ enzymes antioxidant (HO-1, SOD2, Ụlọ ọrụ GCLC); igbochi mmeghachi omume yinye peroxidation lipid dị n'ọtụtụ ụdị mmebi akpụkpọ ahụ.
Nnyocha ụlọ ọgwụ egosila mbelata nke pigmenti anụ ahụ (ihe dị ka 12%) na mmụba nke radiance mgbe na-aga n'ihu 8 ojiji izu.
Cysteine n'onwe ya na-etolite gels na-adịru nwa oge nwere aldehydes efu dị n'elu ebe ọnya, na-emechi microchannel ngwa ngwa ma si otú a na-ebelata okirikiri mkpali.
Upregulation nke VEGF na TGF-β3 na-akwalite granulation anụ ahụ nhazi, ebe a na-egbochikwa akara ngosi scarfibrotic TGF-β1.
COA
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