Palmitoyl Hexapeptide-14, ma ọ bụ nke a na-akpọkarị Palmitoyl Hexapeptide-6, bụ peptide sịntetik bioactive emebere ya na palmitic acid. A na-ejikarị eme ihe n'ime ihe ịchọ mma mgbochi ịka nká, peptide a nwere arụmọrụ edeputara. Moiety palmitoyl n'onwe ya na-ekere òkè dị ukwuu n'ịkwalite ikike akpụkpọ ahụ; bioavailability emelitere bụ otu n'ime nsonaazụ ozugbo. Ezubere iche ụzọ isi jikọtara ya na usoro ịka nká akpụkpọ ahụ, ọ na-eṅomi ụfọdụ ụmụ irighiri ihe mgbaàmà nke extracellular matriks (ECM).
Usoro
{Pal-Phe}-Ala-Leu-Leu-lys-Leu-NH2
Nọmba CAS
891498-01-4
Usoro ihe omimi
C52H92N8O7
Ibu molekụla
941.34 g/mol
Nnyocha nke Palmitoyl Hexapeptide-14
Mmetụta mgbochi wrinkle pụtara kpọmkwem site na ikike nhazi ọtụtụ akụkụ Palmitoyl Hexapeptide-14 na-arụ ọrụ n'elu ECM akpụkpọ ahụ.. Ịka nká akpụkpọ, na ụdi wrinkle guzobe, bụ n'ụzọ bụ isi mmebi nke pathophysiological nke nhazi na akụkụ arụ ọrụ nke ECM kwuru. Mbelata ọkwa na ụbara mmebi nke protein nhazi (collagen bụ isi ihe atụ) bụ isi na usoro a.
Ntinye aka na-arụ ọrụ na oke 'na-atụgharị’ nbibi a bụ ihe peptide nwere ike nweta site na nmimi endogenous. Usoro mmekọrita ugboro atọ na-akọwa otu nke a si eme:
1.Na-akpali akpali Fibroblast Proliferation:
Fibroblasts na-arụ ọrụ dị ka mkpụrụ ndụ ụlọ ọrụ’ nke dermis, synthesizing niile isi ECM components. Nnyocha egosiwo mkpali dị irè (ma n'ọnụọgụ na ọrụ izugbe) nke dermal fibroblasts site na nke a peptide.
Ịbawanye ikike sịntetik nke ECM bụ uru bụ isi nke iji ya.
2.Na-akwalite (kpọmkwem) njikọ nke collagen:
Dị ka e kwuru n'elu, collagen bụ isi ihe nhazi protein maka esemokwu na elasticity nke akpụkpọ ahụ. Ngosipụta kpọmkwem site na peptide ruo fibroblasts na-eduga na mmeju nke opekata mpe ụdị collagen. (Ụdị I/III bụ nke edekọtara nke ọma).
Na-ejuputa obere wrinkles na ọkara bụ ihe a na-ahụ anya nke ukwuu nke mmetụta a.
3.Na-egbochi ọrụ Matrix Metalloproteinase:
Matrix Metalloproteinase/MMP's bụ enzymes na-emebi ECM, na-adịkarịkarị na akpụkpọ ahụ merela agadi ma ọ bụ mebiri emebi. Usoro ikpeazụ na nke dị mkpa nke Palmitoyl Hexapeptide-14, na-echebe ECM (yana collagen niile emebere ọhụrụ ma ọ bụ dịbu adị) si na-agbajikwa.
Netwọk ECM na ọkwa collagen ka dị, ruo n'ọkwa dị ukwuu, emeziwanye.
N'ime izu iri na abụọ, kpuo ìsì abụọ, randomized, nnwale ụlọ ọgwụ na-achịkwa nke metụtara 29 ndị inyom na-arụ ọrụ afọ ofufo, atụnyere ụkpụrụ nwere Palmitoyl Hexapeptide-14 na U.S. Renova® ọgwụ mgbochi ịka nká nke FDA kwadoro (0.05% tretinoin).
Nsonaazụ gosiri na mgbe a oge ojiji, Palmitoyl Hexapeptide-14 tụnyere tretinoin n'ibelata ụdị dị iche iche nke ọmarịcha ahịrị ihu na wrinkles..
Mmetụta ndị a na-ahụkarị na-ejikọta na tretinoin – iyatesịt, akọrọ, na ụdi peeling – anọghị kpamkpam na otu Palmitoyl Hexapeptide-14; ezigbo nnabata anụ ahụ bụ isi ihe a napụrụ na ọmụmụ ihe ahụ.⁵
Usoro nke Palmitoyl Hexapeptide-14 na-arụ ọrụ gụnyere iwughachi na ichekwa matrix extracellular akpụkpọ ahụ.. Ihe omume synergistic ugboro atọ bụ maka ya: A na-akwalite mmụba nke fibroblast, na-akwalite njikọ nke collagen, na matrix metalloproteinase amachibidoro ọrụ.
Na-ebelata wrinkles, nkwụsi ike na elasticity bụ ihe njedebe nke usoro a chọrọ. Ihe ịchọ mma mgbochi mgbanaka na imegharị akpụkpọ ahụ bụ ngwa bụ isi; ude na serum dị nso ụgbọ ala zuru oke maka nnyefe ya.
Nchekwa dị elu na-enye ohere ijikọta oge na ihe ndị ọzọ na-arụ ọrụ.
COA
HPLC
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