Palmitoyl tetrapeptide-7 (Uwe ahụ™) bụ tetrapeptide sịntetik. Usoro nke peptide a sitere na mpempe nke nnukwu yinye nke Immunoglobulin G (IgG), isi protein ahụ mmadụ na-emepụta. Ejikọtara ya na N-terminus na palmitic acid site na njikọ amide, ọ na-agbanwe site n'ịbụ nnukwu mmiri na-agbaze gaa n'ụdị nwere lipophilicity e bu pụta ụwa. Enwere ike ịbanye n'ime ihe mgbochi stratum corneum nke anụ ahụ, na-eru ebe dị iche iche n'ime dermis.
Usoro
Pal-Gly-Gln-Pro-Arg-OH
Nọmba CAS
221227-05-0
Usoro ihe omimi
C34H62N8O7
Ibu molekụla
694.91 g/mol
Nnyocha nke Palmitoyl Tetrapeptide-7
Palmitoyl Tetrapeptide-7 na-adọta mmụọ nsọ sitere na endogenous biomolecules; isi tetrapeptide n'onwe ya (Gly-Gln-Pro-Arg) kwekọrọ na amino acid dị iche iche (341-344 ọ bụrụ na-echeta nke ọma) na IgG. IgG n'onwe ya bụ otu n'ime ọgwụ mgbochi kachasị mkpa, etiti n'ọtụtụ ụdị nke iwu mgbochi ọrịa.
Imimi iberibe a na-enye ọrụ ndu pụrụ iche jikọtara ya na Palmitoyl Tetrapeptide-7 – Mgbanwe usoro mgbochi bụ isi ihe atụ, ọrụ mgbochi mkpali.
Na-eme dị ka peptide na-egosi, kpọmkwem structural 'mgbakwunye’ nke akpụkpọ ahụ abụghị isi ọrụ ya; ijikọ ụfọdụ ndị na-anabata ihe elu cell yana nnyefe nke opekata mpe akara ndụ nke akọwapụtara nke ọma bụ ihe ọ na-enweta..
Nrụzi ekwentị na omume ụdị mmeghari na-esote akara ngosi ndị a.
Mbelata nke secretion basal interleukin-6, Biputere mbufụt nke UVB bụ otu n'ime mmetụta ndị ọzọ enwere ike ịlele, edewo nke ọma.
Laminin na collagens dị iche iche (VII ma ọ bụrụ na m chetara nke ọma) ọgwụgwọ na-emetụta niile nke ọma.
Mmebi glycation (ruo n'ókè ụfọdụ) na-ebelatakwa site na mgbochi mkpali omume nke peptide.
In vivo reflectance confocal microscopy ọmụmụ gosipụtara nkwalite doro anya nke usoro matrix extracellular na ihe ndị a na-emeso..
gafere 60 ndị ọrụ afọ ofufo, emeso ya site na usoro nke nwere Palmitoyl Tetrapeptide-7, gosiri mmụba dị ịrịba ama na nke nwere ike ịpụta na akpụkpọ ahụ foto, na ihe niile ma ọ bụ akụkụ nke uru ndị a kpọtụrụ aha n'elu bụ njedebe nke ọdịdị akpụkpọ ahụ ka mma.
Na ngwa azụmahịa, A na-ejikọta Palmitoyl Tetrapeptide-7 na ya Palmitoyl Tripeptide-1 iji mepụta ihe mgbagwoju anya nke Matrixyl 3000.
Ndị a peptides abụọ na-arụ ọrụ synergistically; Palmitoyl Tripeptide-1 bụ isi na-akwalite njikọ nke collagen, na Palmitoyl Tetrapeptide-7 na-ewere ọrụ mgbochi mkpali dị mkpa.
A na-enweta usoro zuru oke maka ịlụ ọgụ dị iche iche nke ịka nká anụ ahụ site na nchikota a.
Palmitoyl Tetrapeptide-7 n'onwe ya bụ peptide na-egosi nke ọma, biomimetically haziri.
Usoro ihe omume ya pụrụ iche – na-egbochi isi ihe mkpali IL-6 (site n'iṅomi obere iberibe nke immunoglobulin IgG), na-anapụta ma mgbochi mkpali na mgbochi glycation mmetụta; n'otu oge na-eje ozi dị ka ezi molekul na-egosi ma ọ dịkarịa ala akụkụ ụfọdụ na-emegharị dermal fibroblasts. (collagen, elastin, hyaluronic acid bụ ngwaahịa ikpeazụ) – bụ ihe na-enye ya zuru ebe niile na kpọmkwem ngwa uru.
Mgbochi ịka nká na ngwaahịa edoziri ga-enwe ebe maka peptide a mgbe niile.
COA
HPLC
MS
