Palmitoyl tripeptide-5 bụ mgbama sịntetik peptide; Akụkụ tripeptide n'onwe ya bụ isi maka ọrụ ndu ya. Agbakwunyere na nke a bụ otu palmitoyl, nke na-eme ka lipophilicity dị n'ime ya dịkwuo mma. Nke a lipophilicity na-enyere aka ịbanye n'ime ahụ nke ọma site na stratum corneum akpụkpọ ahụ, mmekọrịta kpọmkwem na akpụkpọ ahụ sel dị iche iche yana nlebara anya nke fibroblast dermal. N'ime ụlọ ọrụ ịchọ mma, A na-akpọkarị Palmitoyl Tripeptide-5 site na aha azụmaahịa ya SYN®-COLL. Ngwaahịa nlekọta akpụkpọ anụ dị iche iche na-egbochi ịka nká na-eji ya dị ka ihe a ma ama, nke ukwuu irè akpụkpọ conditioner.
Usoro
Palmitoyl-Lys-Val-Lys-NH₂
Nọmba CAS
623172-55-4
Usoro ihe omimi
C33H65N5O5
Ibu molekụla
611.90 g/mol
Nnyocha nke Palmitoyl Tripeptide-5
Palmitoyl Tripeptide-5 na-eṅomi omume nke thrombospondin - 1 (TSP-1); protein na-apụta n'okike dị na platelet mmadụ. Ụdị anụmanụ na omenala dermal fibroblasts gosipụtara TSP-1 na-eme ka ọgwụgwọ ọnya dịkwuo mma (ime ime obodo bụ usoro izizi) – A na-ekwukwa na ọ bụ protein a ka a na-ekwu na ọ bụ mmepe akpụkpọ ahụ mgbe ọmụmụ gasịrị. TSP-1 n'onwe ya bụ protein matrix extracellular, na-achịkwa nke ọma ihe na-agbanwe uto-β (TGF-β). Usoro Lys-Arg-Phe-Lys akọwapụtara nke TSP-1 dị oke mkpa maka ịkpali TGF ahụ a kpọtụrụ aha.. Ntinye nke TGF na-esote na-eduga n'ịbawanye (na kwadoro) mmepụta nke ma ụdị I na III collagen. Palmitoyl Tripeptide-5, dabere na ihe akaebe, na-arụ ọrụ cascade a niile; A na-eme ka mkpụrụ ndụ akpụkpọ ahụ dịkwuo mma iji kwalite mmepụta collagen.
Ọmụmụ anụmanụ na-egosi na palmitoyl tripeptide-5 na-akwalite njikọ nke collagen. Ọrụ in vitro egosila ma ọ dịkarịa ala mgbochi akụkụ nke mmebi nke collagen (MMP1/MMP3 bụ nnyonye anya elekwasị anya). A na-ahụkwa ịkwalite njikọ na ibelata ndakpọ dị ka usoro omume dị irè. Ihe omuma agbakwunyere site na nyocha emere nke oma na-egosi na odi nma nke palmitoyl tripeptide-5 n’ibelata mputa nku., ruo n'ókè a pụrụ ịtụtu ihe. Edebere usoro onunu ogwu na oge dabere na mbenata wrinkles.
N'ime ọmụmụ arụmọrụ metụtara 60 Ndị ọrụ afọ ofufo China (84 ụbọchị, ngwa ugboro abụọ kwa ụbọchị), Pal-KTTKS gosipụtara arụmọrụ mgbochi nhịahụ dị elu yana nkwalite ụdị dị iche iche nke akpụkpọ ahụ ma e jiri ya tụnyere otu njikwa., otu placebo, na ude nwere otu ihe na-arụ ọrụ.
Palmitoyl Tripeptide-5 na-arụ ọrụ nke ọma na TGF-β site na iṅomi ụzọ mgbaàmà nke anụ ahụ.; mmụba nke njikọ akpụkpọ ahụ nke ụdị I na III collagen na-esote, nwere ike igbochi mmebi ya. In vitro na ọtụtụ ọmụmụ ụlọ ọgwụ ekwenyela na mbelata ahụhụ a dị ịrịba ama, udidi na-emeziwanye, na ruo n'ókè dị ukwuu firming mmetụta. Mgbochi wrinkle dị obosara, ikwado (akụkụ ma ọ bụ zuru ezu) na ịrụzi ngwaahịa nlekọta anụ ahụ gụnyere peptide a – serum, ude, anya na olu kpọmkwem ngwaahịa bụ isi ihe atụ.
COA
HPLC
MS
