Tripeptide-29 bụ peptide ịchọ mma a na-ejikarị eme ihe n'ime serum ụbọchị, ngwaahịa nlekọta mgbe anyanwụ gasịrị, na nrụzi ihe mgbochi na-eso usoro ọgwụgwọ ahụike dị iche iche.
E nwetara site na mkpọpu nke Gly-Pro-Hyp, Iberibe a pere mpe na-anọchi anya nkwughachi kachasị elu nke achọtara na yinye α1 nke Ụdị I collagen; na-ejigide Nkwekọrịta nke okpukpu atọ-helix nke collagen kwuru bụ ọrụ dị mkpa ya.
Ọmụmụ ihe ọmụmụ thermodynamic egosila iberibe trieptide a ka ọ kwụsie ike n'usoro, ihe njikọ intramolecular hydrogen netwọk (pyrrolidine mgbanaka ka hydroxyl otu bụ isi ihe) budata ịgbatị ọkara ndụ ya in-vivo.
Nhazi obere iberibe n'onwe ya na-ezere mmetụta ndị metụtara nke agbụ peptide ogologo, ọzọ hydrophobic Ọdịdị eme ka akpụkpọ permeability.
Usoro
Gly-Pro-Hyp
Nọmba CAS
2239-67-0
Usoro ihe omimi
C12H19N3O5
Ibu molekụla
285.30
Nyocha metụtara Tripeptide-29
1.Ihe omume ndị dị mkpa
A na-ejigide nrụpụta zuru oke nke yinye nne na nna collagen α1; A na-eṅomi nrịbama emebibeghị, na-arụ ọrụ fibroblast ụzọ kpọmkwem maka njikọ nke collagen – mmepụta nke collagen ọhụrụ bụ njedebe ikpeazụ, Mbelata nke wrinkle bụ otu n'ime nsonaazụ ndị a na-atụtu ọnụ karịa.
Na-egbochi ikwubiga okwu ókè nke matrix metalloproteinase bụ mmetụta ọzọ dị mma, A na-egbochi njikọ enzyme na-emebi emebi maka nlanarị collagen dị mma.
Akwụsịla mmeghachi omume oxidation chain, Kemịkalụ sunscreen larịị bụ isi foto mmebi iwu na-anapụta (mgbochi na hydration ọrụ na-ewusi ike).
Ịchịkwa aka nke ihe omume ndị a niile dị larịị na-ewulite ezigbo mmezi akpụkpọ ahụ yana ụzọ mgbochi ịka nká..
2.Mweghachi nke Collagen
Mmekọrịta dị elu na-ejikọta ya TβR-III (Ihe na-agbanwe uto beta receptor III) bụ ihe na-edobe Tripeptide-29 iche; A na-eme ka akara ngosi mmebi iwu nke ọma.
Ọhụrụ, A na-emepụta collagen ụdị I na nke atọ dị ka ihe si na ya pụta.
Ike siri ike, dermis na-eto eto bụ ihe a hụrụ.
3.Mgbochi mmebi nke Collagen
Tripeptide-29 na-egbochi oke mmepụta nke matrix metalloproteinases (Ndị MMP) n'ime sel anụ ahụ.
Mbelata nke ụzọ mgbaàmà intracellular akọwapụtara na ngosipụta nke ihe mkpasu iwe dị iche iche bụ isi usoro na usoro a..
N'okwu mkpụrụ ndụ ihe nketa, Akwụsịla okwu MMP; mfu nke netwọk collagen e guzobere na mbụ na-ebelata.
A na-enye ebe kwụsiri ike maka njikọta na nhazi nke collagen ọhụrụ.
Ịgbatị oge ntorobịa nke akpụkpọ ahụ bụ isi ihe si na omume a pụta; A na-edobe ike akpụkpọ ahụ site na usoro a na-aga n'ihu.
4.Nchedo foto na mmetụta na-egbuke egbuke
Nnyocha na-egosi na Tripeptide-29 na-etolite oke Nkwekọrịta nke okpukpu atọ-helix na mpụta akpụkpọ anụ nke melanosomes.
Ọrịa Tyrosinase a na-egbochi ịbanye n'ime cell, kpọmkwem melanin a na-egbochi mmepụta ihe.
A na-ebelata mmebi UV na akpụkpọ ahụ, ọbụnadị ụda anụ ahụ na-esochi ikpughe ogologo oge na-eme.
Nnukwu ntachu metụtara ọbara ọbara, ọzịza na ọkụ sensations na-budata ibelata.
Na-adịghị ala ala ịse foto ihe ịrịba ama adịghị njọ n'ihi ya.
Dakọtara na ụdị ọ bụla nke mkpuchi anwụ nke azụmahịa, A na-enweta nchedo foto zuru oke.
COA
HPLC
MS
