Tripeptide-32

Nyocha metụtara Tripeptide-32

Emebere Tripeptide-32 na mbụ ka o lekwasịrị anya na ịhazi mkpụrụ ndụ ihe nketa PER1 (Oge Circadian Regulator 1). A na-ewere nke a dị ka otu n'ime mkpụrụ ndụ ihe nketa dị n'ime elekere nke ndu; na-edobe rhythm circadian nke anụ ahụ bụ ebumnuche ya bụ isi.

N'adịghị ka ọtụtụ peptides antioxidant ọdịnala (bran osikapa bụ isi ihe atụ), Usoro ihe omume kachasị ama maka tripeptide-32 dabere na ụkpụrụ a. PER1 n'onwe ya bụ akụkụ bụ isi nke elekere kwuru.

Mmekọrịta na mkpụrụ ndụ ihe nketa ndị ọzọ, isi site na a nzaghachi na-adịghị mma loop (CLOCK na BMAL1 dị ka isi atụ), na-achịkwa mgbanwe mgbanwe oge nke ọtụtụ usoro physiological na-esote – okirikiri ụra/ụta, metabolism, mmezi cell ịkpọ aha ole na ole.

Tripeptide-32 na-arụ ọrụ site na ọtụtụ ụzọ ejikọrọ ọnụ: na-achịkwa usoro rhythm circadian. Mkpụrụ ndụ akpụkpọ ahụ, dị ka sel anụ ahụ niile, nwere usoro elekere nke ndu ha; CLOCK na mkpụrụ ndụ ihe nketa PER1 bụ 'isi’ nke ya.

Mkpụrụ ndụ CLOCK na-arụ ọrụ dị ka onye mmalite’ maka ịgbalite ọtụtụ mkpụrụ ndụ ihe nketa metụtara ọrụ cellular n'oge a kara aka, ihe omume PER1 na-emetụta mitochondrial ọrụ, mmeghachi omume antioxidant dị iche iche na oke ike metabolism.

Mmekọrịta PER1 na GPX1 (glutathione peroxidase 1) bụ otu ihe atụ – na-amụba ya scvenging nke ụdị oxygen reactive, ibelata njikọ nrụgide oxidative.

Nnyocha na-aga n'ihu na-egosi nrịbama mpụga dị irè site na tripeptide-32.

Site n'ịkwalite ndegharị nke mkpụrụ ndụ ihe nketa elekere ndị a, tripeptide-32 nwere ike inye aka “mekọrịta” ma ọ bụ “tọgharịa” etisasịwo akpụkpọ ndu clocks.

Omume physiological dị iche iche n'ime sel na-eme n'oge a kapịrị ọnụ; idobe oge a ziri ezi bụ isi ọrụ nke usoro elekere.

Na-akpali njikọ nke protein mmezi cell: Rhythm circadian nkịtị na-achịkwa njikọ nke ọtụtụ protein metụtara nrụzi.

Tripeptide-32, site n'ụzọ mgbama PER1 gbakọrọ aka, na-eme ka mmepụta nke akụkụ matrix extracellular – collagen bụ isi ihe atụ, yana ụdị elastin ndị ọzọ n'ozuzu ya.

A na-enye ihe ndabere ihe maka ụdị nrụpụta cell niile site na usoro a.

PER1 n'onwe ya na-ahazi mkpụrụ ndụ ihe nketa okirikiri cell (p53 ịbụ otu, Cyclin D1 ma ọ bụrụ na m chetara nke ọma), na-edozi ma mmụba na apoptosis na-esote; A na-emeziwanye ọrụ mgbochi akpụkpọ anụ na ikike nrụzi site na iwu a mgbe niile.

Na-eme ka cell viability na ndụ: Nnyocha ụlọ nyocha egosila mkpụrụ ndụ akpụkpọ ahụ ejiri tripeptide-32 na-agwọ ya ka ha nwee ike dị ike karị na ịdị ogologo ndụ. (opekempe n'otu akụkụ n'ihi usoro nrụzi a kpọtụrụ aha n'elu).

A na-ahụkwa mmụba ike ike.

Ezi mmetụta mgbochi ịka nká bụ n'ókè ụfọdụ antioxidant na mgbochi mkpali; na-ebelata mkpokọta mitochondrial ROS bụ isi.

Ụzọ PER1 na-eduga na ihe niile dị n'elu, emelitere ma ọ bụ nso-nkịtị ATP (Adenosine triphosphate) mmepụta na mgbochi nke ihe ndị na-egbu egbu.

Ọrịa ndị metụtara afọ (ọrịa kansa, neurodegeneration bụ ihe atụ abụọ doro anya) Ejikọtara ha niile na ụkọ PER1, ya mere tripeptide-32 nwere ike ịgwọ ọrịa bụ ebe dị ezigbo mkpa ma dị mkpa nke nyocha.

Dabere na usoro ya bụ isi nke na-achịkwa rhythm circadian, tripeptide-32 na-egosi ọtụtụ ike ngwa n'ofe ọtụtụ ubi.

Akpụkpọ ahụ na-egbochi ịka nká bụ otu n'ime ebe emebere nke ọma, ihe a na-akwalite njikọ nke collagen na n'ọnọdụ ụfọdụ, ọrụ mgbochi n'ozuzu; imekọrịta elekere cellular nke akpụkpọ ahụ bụ usoro izizi ya.

Ọbara mmezi abalị dị elu nke Estee Lauder (ọgbọ nke asaa, kwalitere na nso nso a ulo oru ọzọ na April 2025) bụ ezigbo ihe atụ – Bifida Ferment Lysate jikọtara ya na Tripeptide-32 bụ akụkụ nke isi usoro ha.

Ndị ọrụ nyocha in vitro ha na-enye na-akwado ojiji a, na-abawanye (opekata mpe nwa oge) mmepụta ATP (ihe dị nso zuru ụwa ọnụ n'ụdị nrụzi cell niile) site ruo 46%, na njikọ nke lipid kpọmkwem n'ime ihe mgbochi na-eso ogologo oge nke 'ịnọ ọdụ n'oge'.

Ọrịa Neurodegenerative bụ akụkụ ọzọ nke mmasị; njikọ chiri anya na ọrịa circadian metụtara na-eme ka ụdị ọrịa Alzheimer bụrụ ebumnuche ezi uche maka itinye aka ọ bụla site na peptide a..

Mkpụrụ ndụ PER1 (iji kọwakwuo ya) na-arụ ọrụ na-ebelata etuto edekọ nke ọma, ya mere ọgwụgwọ ọrịa cancer adjuvant site na iji tripeptide-32 ma ọ bụ ihe mmepụta, bụ usoro nyocha nke a na-eme ugbu a.