NA Selank Amidate exhibits improved molecular stability and in vivo pharmacokinetic profile through a double-modification strategy of N-terminal ಅಸಿಟೈಲೇಷನ್ and C-terminal amidation based on the original structure of ಸೆಲಂಕ್.
This results in an increased half-life, ವರ್ಧಿಸಲಾಗಿದೆ ರಕ್ತ-ಮಿದುಳಿನ ತಡೆಗೋಡೆ penetration efficiency, and prolonged bioactivity in both molecular and animal models.
ಮೇಲಾಗಿ, NA Selank Amidate exhibits potent ಇಮ್ಯುನೊಮಾಡ್ಯುಲೇಷನ್ and anti-stress activity.
ಅನುಕ್ರಮ
ac-thr-lys-pro-arg-pro-gly-pro-nh2
CAS ಸಂಖ್ಯೆ
/
ಆಣ್ವಿಕ ಸೂತ್ರ
C35H60N12O9
ಆಣ್ವಿಕ ತೂಕ
792.94
Research Of NA Selank Amidate
1.Retained and Enhanced Efficacy
Efficacy-wise,NA Selank Amidate retains all of the characteristics of Selank, ನಿಯಂತ್ರಿಸುವುದು gamma-aminobutyric acid (GABA) neurotransmission in the brain while also modulating the dopaminergic ಮತ್ತು ಸಿರೊಟೋನರ್ಜಿಕ್ systems to deliver outstanding ಆಕ್ಸಿಯೋಲೈಟಿಕ್ ಮತ್ತು antidepressant effects.
It also shows better efficacy than Selank in enhancing cognitive and neuroprotective functions, producing pronounced positive effects on learning, memory, and attention.
2.Anxiolytic and Mood-Stabilizing Effects
In a concentration-dependent and subtype-selective manner, NA ಸೆಲ್ಯಾಂಕ್ ಅಮಿಡೇಟ್ allosterically modulates ದಿ GABA-A receptor by potentiating the binding efficacy of GABA to its receptor or enhancing chloride ion channel opening efficiency.
This significantly increases the inhibitory tone in key brain circuits, producing marked anxiolytic effects.
ಇದಲ್ಲದೆ, the side effects of this anxiolytic action are significantly milder than those of conventional anxiolytic drugs, making NA Selank Amidate a more attractive mood-stabilizing compound.
3.Cognitive Enhancement and Neuroprotection
NA Selank Amidate directly activates ಬಿಡಿಎನ್ಎಫ್ gene transcription by inducing ಫಾಸ್ಫೊರಿಲೇಷನ್ of the promoter-located CREB transcription factor and acetylation of histone H3, increasing BDNF mRNA levels 3.2-fold in hippocampal dentate gyrus granule cells and prefrontal cortical pyramidal neurons and protein secretion 2.8-fold within 24 ಗಂಟೆಗಳು.
This activates the TrkB receptor signaling pathway downstream, inducing the Ras-MAPK and PI3K-ಆಕ್ಟ್ cascade to increase ಡೆಂಡ್ರಿಟಿಕ್ ಬೆನ್ನುಮೂಳೆ density by 39%, upregulate synaptophysin expression by 45%, and restore LTP amplitude to baseline.
This successfully prevents stress-induced hippocampal neuronal injury and cognitive decline, demonstrating distinct neuroprotective properties.
4.Immunomodulatory and Anti-Stress Effects
NA Selank Amidate is a competitive inhibitor of enkephalin-degrading enzyme, protecting endogenous ಒಪಿಯಾಡ್ ಪೆಪ್ಟೈಡ್ಗಳು ನಿಂದ hydrolysis and thereby elevating their levels, while it inhibits LPS (lipopolysaccharide)-induced expression of pro-inflammatory ಸೈಟೊಕಿನ್ಗಳು ಸೇರಿದಂತೆ IL-6 ಮತ್ತು TNF-α by 40–60% in astrocytes.
NA Selank Amidate also represses NF-κB nuclear translocation by interfering with the recruitment of MyD88 adaptor protein, providing protective regulation in the neuroinflammatory microenvironment.
COA
HPLC
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