Acetyl hexapeptide 1 (lebitso la khoebo Melitane) ke peptide ea maiketsetso ea bioactive.
Ho entsoe lipatlisiso tse pharaletseng mabapi le motsoako ona, 'me tšebeliso ea eona ka har'a tšimo ea litlolo e ngotsoe hantle.
Anti-wrinkle ea eona e mengata, lokisa, le lintho tse sireletsang letlalo li tsejoa hantle.
Tatelano
Ak-{Ka}-Ala-Hae-{d-Phe}-Arg-Trp-NH2
Nomoro ea CAS
448944-47-6
Foromo ea limolek'hule
C43H59N13O7
Boima ba Molek'hule
870.01 g/mol
Patlisiso ea Acetyl Hexapeptide 1
Acetyl hexapeptide 1 e bontša mesebetsi e mengata e mengata ea likokoana-hloko; liphello tse ananeloang ka ho pharaletseng li finyelloa ka litsela tse peli tse fapaneng haholo tsa limolek'hule.
Ho loantša wrinkles le pigmentation regulation ke mehlala e meholo ea bokhoni bona.
Ka ho fetisisa a hlokomela tshebetso – anti-wrinkle ho ba eona ea mantlha – targets lines tlhaloso (makukuno a mahlahahlaha ka ho khetheha).
E tšoana le Acetyl Hexapeptide-8 (Argireline), mokhoa ona oa ketso ke oona o hlalosang tšebeliso ea oona.
Ts'ebetso ea mantlha e khahlanong le wrinkle e kenyelletsa ho kena-kenana le phetiso ea mats'oao sebakeng sa neuromuscular junction.
Boithuto bo bonts'a tšebelisano ea nako e le 'ngoe ea presynaptic le postsynaptic.
Presynaptically, tlholisano e tlamang ho Mosebetsi-18 protheine thibela ho tlala Soluble N-ethylmaleimide-sensitive factor Attachment protein Receptor (LERABA) kopano e rarahaneng, ho fokotsa ho lokolloa ha acetylcholine e le phello e tobileng.
Ho fokolisa lets'oao la konteraka le amoheloang ke mesifa ka boeona ho lebisa ho phutholoha ha mesifa.
Postsynaptic, Acetylcholine (ACh) ts'ebetso ea li-receptor e thibetsoe, khalsiamo e ngata e fokotsehile, ho honyela ha mesifa ho ile ha fokotseha 'me ka hona makukuno a matla a fokotseha.
Inhibitory efficiencies of up to 37% (E amanang le SNARE) le 29% ntlha ea ho lokolloa ha acetylcholine ho monyetla o hlakileng oa potency ho feta Argireline.
Motsotsoana, empa le bohlokoa ka ho lekana, karolo ea bohlokoa ea Acetyl Hexapeptide 1 ke ts'ebetso ea eona ea agonist ho α-MSH.
Natural α-MSH ke hormone ea endogenous; tlama ho Melanocortin 1 moamoheli (MC1R) melanocyte receptors e qala lets'oao le amanang le pigment.
Acetyl hexapeptide 1 e etsisa mosebetsi ona.
Tlhokomelo ea 'mala oa moriri le ho lieha ho putlama, ka ho hlohlelletsa melanocyte, ke e 'ngoe ea lisebelisoa tsa bohlokoa tsa khoebo tsa mofuta ona oa lipatlisiso.
A 2023 boithuto bo ile ba lekola katleho ea serum e nang le supramolecular retinol le Acetyl hexapeptide. 1 ka ho ntlafatsa letlalo la sefahleho le bonolo le nang le photoaged.
Basali ba Machaena ba lilemo tse mahareng ba mashome a mararo a metso e 'meli ba ile ba kenya letsoho thutong ena; nako ea phekolo ea libeke tse 8 e ne e le sepheo sa lipatlisiso.
Lintlafatso likarolong tse fapaneng tsa lithuto’ boemo ba letlalo bo ile ba hlokomeloa.
Hajoale, Acetyl hexapeptide 1 e kenyelelitsoe haholo lihlahisoa tsa premium tse thibelang botsofali – li-serum ke mofuta o atileng haholo, ka litlolo le lihlahisoa tse khethehileng tsa mahlo tse latelang.
Lisebelisoa tsa setso tsa neuromodulatory (Chefo ea botulinum ke mohlala o ka sehloohong) ba behile tekanyetso ea hore na ho thibela botsofali ho ka shebahala joang; tshebediso e sa hlaseleng, polokeho e phahameng, le mamello e ntle e etsa Acetyl hexapeptide 1 e loketse bakeng sa tšebeliso ea nako e telele ea letsatsi le letsatsi ho skincare.
COA
HPLC
MOF
