Acetyl Hexapeptide-38 (lebitso la khoebo Adifyline®) ke peptide ea maiketsetso e sebelisoang haholo ka har'a moriana oa botle le tokiso ea letlalo. Ho lebela dermal fibroblasts, e khothalletsa collagen synthesis le subcutaneous mafura thickening; ntlafatso ea sebopeho sa letlalo le mefuta e sa tšoaneng ea tokiso ea lisele ke liphello tse tobileng tsa mosebetsi ona.
Tatelano
Ac-Ser-Val-Val-Val-Arg-Thr-NH₂
Nomoro ea CAS
1400634-44-7
Foromo ea limolek'hule
Setšoantšo sa C30H56N10O9
Boima ba Molek'hule
700.83 g/mol
Acetyl Hexapeptide-38 ke eng?
Acetyl Hexapeptide-38 ka boeona ke peptide e fetotsoeng ea acetylated – li-amino acid tse tšeletseng ka bolelele. Moralo oa limolek'hule oa peptide o etsisa li-peptide tsa tlhaho tsa bioactive, ka melemo e eketsehileng ea botsitso bo eketsehileng le ho matlafatsa matla a letlalo.
E qalile ho hlahisoa ke lik'hamphani tsa litlolo le tsa biomaterial, mathata a ho tsofala ha letlalo (wrinkles, botsoa, bofokoli ba linama tse bonolo ho ba mehlala e meholo) ke seo peptide ena e etselitsoeng ho sebetsana le eona. Lipatlisiso li bontšitse ho kenella ka katleho ho feta mokoallo oa pele oa letlalo; ho sebetsa ka hara letlalo la letlalo, taolo ea extracellular matrix metabolism ke ts'ebetso e ka sehloohong e lebisang mefuteng eohle ea ntlafatso ea sebopeho le tokiso e latelang..
Mosebetsi oa mantlha oa Acetyl Hexapeptide-38 ke ka hona e le motšehetsi oa ho lokisa lisele tse pharalletseng. Li-fibroblasts tsa letlalo le li-adipocytes ke lipheo tsa mantlha, ka lits'ebetso tse ikhethileng tsa baeloji tse laoloang hohle.
Hona joale mokhoa oo ho buisanoang ka oona ka ho fetisisa o kenyelletsa ho susumetsa polelo ea Peroxisome Proliferator Activated Receptor Gamma Coactivator 1-alpha (PGC-1A). PGC-1α ke molaoli ea ka sehloohong oa biogenesis ea mitochondrial le tsohle tse amanang le metabolism ea matla. Ho phahama ha protheine ena ho lebisa ho (bonyane ka mokhoa o itseng) ho eketseha ha lipid synthesis le ho bokellana ho adipocytes – keketseho ea molumo oa lisele tsa adipose ke phello ea ho qetela. Ho ruruha ha letlalo le ho fokotseha ha wrinkles ea atrophic ka bobeli ke lipontšo tse ntle tsa kliniki tsa phello ena.
Thepa ena e etsa hore ho be le mofuta oa tlhaho oa ho eketsa bongata ba mafura (marama a sefahleho, matsoele joalo-joalo.) ho fihleloa; 'Peptide ea ntlafatso ea matsoele’ ke tlhaloso e tloaelehileng ea bonyane tse ling tsa tšebeliso ea eona.
Acetyl Hexapeptide-38 e matlafatsa letsoalo le botsitso ba likhoele tsa collagen dermis, joalo ka ha ho boletsoe pejana, ka liphello tsohle tse ka holimo tse kopantsoeng.
E itšetlehile ka mekhoa eohle e hlalositsoeng, Acetyl Hexapeptide-38 e na le bokamoso ba 'nete le bo ts'episang haholo meriana ea botle. Ho lokisa litsela tse peli le ho teteana ha lisele tse bonolo ke ntlha e lakatsehang ea ho qetela.
Acetyl Hexapeptide-38 ke moemeli ea tšepisang oa ho lokisa letlalo.
COA
HPLC
MOF
(2) DELGADO GONZÁLEZ, R.; SOLE ASTALS, A.; LEKHOTLA, A.; TS'ELISITSOE, B. EXOPOLYSACCHARIDE BAKENG SA KAPELO LE/KGOTSA HO HLOKOMELA LETLALO, LITHO TSE KHABANE LE/KAPA LINALA. EP2827837B8.
(3) Wu, Y.; Ee, H.; Lyu, Y. Tsoelo-pele ea lipatlisiso tsa li-peptide tsa tlhaho tsa collagen le katleho ea eona ea letlalo. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2022, 39 (6), 1254-1262. DOI: 10.7507/1001-5515.202207009 Ho tsoa ho NLM.
