Acetyl Tetrapeptide-11 (lebitso la lebitso la Syniorage™) ke peptide ea maiketsetso ea maiketsetso. Patlisiso e batsi ea lefapha la litlolo e tsepamisitse maikutlo ho matla a eona a ho ntlafatsa matšoao a fapaneng a botsofali ba letlalo.; elasticity, ho tiea, le mofuta oa khanya e le e meng ea mehlala e ngotsoeng hantle.
Tatelano
Ac-Pro-Pro-Tyr-Leu
Nomoro ea CAS
928006-88-6
Foromo ea limolek'hule
C27H38N4O7
Boima ba Molek'hule
530.6 g/mol
Patlisiso ea Acetyl Tetrapeptide-11
Ts'ebetso ea mantlha ea bioloji ea Acetyl Tetrapeptide-11 e mabapi le ho boloka le ho lokisa maemong a mang., bokhabane ba sebopeho le ts'ebetso ea Motsoako oa Dermal-Epidermal Junction (METSI). Litsela tse peli tsa mantlha li ikarabella bakeng sa mokhoa ona oa ts'ebetso:
E susumetsa ho ata ha keratinocyte: Keratinocyte e etsa li-epidermis ka botsona. Ho ata ho tloaelehileng le phapang e latelang ke likarolo tsohle tsa thibelo ea letlalo e sebetsang hantle, botsitso ba sebopeho, le ho itokisa ka tekanyo e kholo. E le pontšo ea peptide e khothalletsa ka ho toba kgolo ea epidermal keratinocyte, ho eketseha ha letsoalo la lisele e le sephetho se le seng se ka lekanyetsoang, ho potlakisa ho nchafatsa e le phello ea ho qetela ea ts'ebetso ena.
Ho Khothalletsa Glycoprotein Synthesis – ka ho toba syndecan-1 le ho isa ntlheng mofuta XVII collagen. Syndecan-1 (transmembrane heparan sulfate proteoglycan haeba ke hopola hantle) tlama ligands (limolek'hule tsa ho khomarela lisele, lintlha tse fapaneng tsa kholo) ka liketane tsa eona tse mahlakoreng; ho khomarela li-intercellular le litšebelisano tsohle tse amanang le microenvironmental li laoloa. Mofuta oa XVII collagen ke karolo e haufi ea bohlokoa ea li-hemidesmosomes. E fokotsehile synthesis ea leha e le efe, ka botsofali, e isa ho omella, botsoa bo boletsoeng pejana. Ho ntlafatsa ts'ebetso ea litšitiso le khanya ke melemo ea bobeli ea Acetyl Tetrapeptide-11.
Litlaleho tse ling tsa mahlale li bonts'itse thibelo e haufi e felletseng ea matšoao a phetiso ea neuromuscular (ka ho thibela li-receptor tsa SNARE), ho fokotsa ho lokolloa ho feteletseng ha catecholamine le acetylcholine. Maswebe a matla a fokotswa ke ketso ena hape.
Liphuputso tsa bongaka li tiisa hore metsoako e nang le acetyl tetrapeptide-11 (mohlala, ho a 3% ho tsepamisa maikutlo) haholo eketsa botenya ba letlalo le ho tiea. Teko e le 'ngoe ea katleho e amehang 19 baithaopi ba basali; sehlahiswa seo ho buuwang ka sona e ne e le sona feela se sebetsang. Liphetho li ne li hlakile, phapang e ka lekanyetsoang ho tsoa sehlopheng sa taolo ea placebo – batho ba sebelisang acetyl tetrapeptide e nang le sebopeho e ne e le motenya, letlalo le tiileng haholoanyane.
Thuto ena e tšehetsa ka matla phetolelo’ ea mefuta e fapaneng ea in vitro e hlokometse mesebetsi ea likokoana-hloko ho ntlafatsa letlalo le bonahalang. Bopaki bo khahlanong le botsofali ke seo motsoako ona o itlhommeng ka oona.
Ka lebaka la mokhoa ona o ikhethang oa ts'ebetso, Acetyl Tetrapeptide-11 haholo-holo e kenyelelitsoe mefuteng e phahameng ea litlolo tse thibelang botsofali.. Ho tiea ha letlalo, tekano (tsa mefuta e fapaneng), 'me contour e bonolo ka kakaretso kaofela e ntlafatsoa ke eona.
Li-peptide tse tšoaeang li sebetsa joalo ka limolek'hule tsa manqosa tse phethahetseng; Likarabo tse matla empa tse ikhethang tsa cellular lia hlohlelletsoa, maemo a tlase ke sona feela se hlokahalang. Maemo a phahameng kapa a haufi a kamehla a peptide ka boeona ha a hlokehe – likarolo ka mefuta e meng ea mefuta ea milione li tloaelehile ebile lia sebetsa.
COA
HPLC
MOF
