Acetyl Tetrapeptide-9 (lebitso la lebitso Dermican™) ke bioactive peptide e sebelisoang haholo ho thibela botsofali ba letlalo. Stimulating the synthesis of different key matrix a extracellular dikarolo, e ntlafatsa haholo elasticity ea letlalo le ho tiea; ho itlhahisa e le motsoako o haufi oa bohlokoa oa litlolo tsa sejoale-joale tse sebetsang.
Tatelano
Ac-Gln-Asp-Val-His
Nomoro ea CAS
928006-50-2
Foromo ea limolek'hule
C22H33N7O9
Boima ba Molek'hule
539.54 g/mol
Patlisiso ea Acetyl Tetrapeptide-9
Acetyl Tetrapeptide-9 e behiloe haholo-holo e le 'dermal remodeler.’ Botšepehi ba sebopeho le lisebelisoa tsohle tsa mochini tse amanang le letlalo li itšetlehile haholo ka matrix a extracellular (ECM); boleng ba fiber ea collagen le tlhophiso e latelang e bohlokoa haholo. Botsofali bo lebisa ho fokotseng motsoako oa ECM le ho senyeha ho eketsehileng, tšitiso ea seo e kileng ea e-ba marang-rang a collagen a laetsoeng hantle – matšoao a bonahalang a botsofali (wrinkles, botsoa ho ba mehlala e meholo) latela. Morero oa nts'etsopele ea peptide ena ke ntlafatso e hlophisehileng 'me maemong a mang ke tsosoloso, ea sebopeho sena sa letlalo se phetseng hantle; ho kenella boemong ba bohlokoa ba motsoako oa ECM e le mokhoa oa ho e fihlela.
Ho ikhetha ha Acetyl Tetrapeptide-9 ha hoa itšetleha feela ka ho khothaletsa tlhahiso ea collagen ea Mofuta oa I., empa ka ho teba haholoanyane ketsong ea eona ho mohlophisi ea haufi’ ea kopano ea collagen e boletsoeng – lumican. Lipatlisiso li bonts'itse ho phahama ho hoholo ha ketane ea α1 ea Mofuta oa I collagen (COL1A1) le lumican polelo ea lefutso. Lintlha tsa liteko li tiisa ho eketseha ha maemo a fibroblast a hlahisoang ke liprotheine ka bobeli; Type I collagen mme ho isa tekanyong e kholo lumican ka boeona.
Thuto e kenyeletsang 17 baithaopi ba basali (tsofetseng 45-55) sebelisa tranelate e nang le 0.9% Dermican™ bakeng sa 16 libeke. Litlhahlobo tsa ultrasound le kliniki ea palpation ea letlalo e ne e le mehato ea ntlafatso; botenya le ho tiea ka bobeli li bontšitse liphetoho tse ntle. Ka letšoao la libeke tse 8 bonyane 82% e tlaleha ntlafatso e hlokomelehang likarolong tsohle tsa ho tiea ha letlalo.
Acetyl Tetrapeptide-9 e bonts'a botsitso bo botle mme e ka kopanngoa le tse ling tse sebetsang (vithamine C, asiti ea hyaluronic, li-sunscreens joalo-joalo.) ho ntlafatsa ts'ireletso ea foto. Litlamorao tsa Synergistic le li-peptide tse ling li ngotsoe hantle.
Khahlanong le botsofali ke ts'ebetso e sebetsang 'me Dermican™ ke karolo ea tokiso ea 'nete le e lekantsoeng ea letlalo.. Ho tiea ha letlalo le botenya, ho merero le merero eohle, ke katleho ea mohala ona oa li-peptide tse sebetsang.
COA
HPLC
MOF
