Acetyl Tripeptide-1 ke peptide ea maiketsetso ea tokiso, e entsoe ka N-terminal acetylation ("capping" phetoho) ea tlhaho ea tlhaho ea tripeptide GHK e fumanoang ho plasma mme e na le sebopeho sa lik'hemik'hale se ts'oanang le Acetylated Polypeptide-1. Phetoho ena ea sebopeho e sebetsana le liphephetso tse boletsoeng ka holimo tsa GHK ea mantlha, ho kenyeletsa ho hloka botsitso ka lebaka la li-aminoxidase, inactivation ho litlolo tsa litlolo, le halofo ea bophelo bo bokhutšoanyane.
Ka kakaretso, Acetyl Tripeptide-1 ka katleho e fokotsa mela e metle le makukuno, e tiisa letlalo, le ho hloekisa letlalo la letlalo. Ke motsoako o thibelang botsofali o nang le mokhoa o hlakileng oa ho sebetsa, tse khethehileng haholo, mme a bontsha bokgoni.
Tatelano
Ac-Gly-His-Ls-OH
Nomoro ea CAS
350595-76-5
Foromo ea limolek'hule
C16H26N6O5
Boima ba Molek'hule
382.42
Lipatlisiso tse amanang le Acetyl Tripeptide-1
1.Mekhoa ea Motheo le Liphello tse nang le likarolo tse ngata
Lipontšo tsa GHK tse nang le acetylated li ile tsa eketseha hydrophobicity le bophelo bo bolelele ba halofo ha u ntse u boloka Cu²⁺ ea eona e ka fetolehang-chelation thepa. Lintho tsena li thusa ho theha li-complexes tsa koporo-peptide ka har'a dermal layer, ho matlafatsa bokgabane ntle le ho eketseha cytotoxicity.
E sebetsa ho dermal fibroblast lisele ho thibela botsofali bo bakoang ke tatellano ea liketsahalo kapa maemo a tikoloho. Ka ho tlama ho li-receptor tse khethehileng tsa holim'a lisele, e etsa hore ho be le li-cascades tse kholo tsa intracellular ho fetola tšebetso ea lisele ho liphatsa tsa lefutso.
E susumetsa ka matla ho kopanya le ho hlahisa mofuta oa I & III collagen le elastin, e bakang ho teteana, letlalo le letenya. Sena, ka mor'a moo, e fokotsa wrinkles, sagging, le sekoti se bakoang ke tahlehelo ea collagen.
E boetse e hatella tšebetso e feteletseng ea matrix metalloproteinase, ho theha microenvironment e sireletsang ea letlalo e fokotsang ho senyeha ha matrix a matsoalloa a extracellular.
2.E khothalletsa Collagen le Elastin Synthesis
Acetyl Tripeptide-1 e fihla lera la letlalo la letlalo, moo e sebetsang joalo ka ligand bakeng sa li-receptor tse khethehileng ho membrane ea sele ea fibroblast. Tlamahano ena ea sebetsa protheine kinase e kentsoeng ke mitogen (MAPK) le phosphoinositide 3-kinase (PI3K) litsela tsa lipontšo, ho khothalletsa ho ata ha fibroblast le ho laola anabolic metabolism.
Ho mongolo oa mongolo boemo, e ntlafatsa polelo le tlhahiso ea mofuta oa I collagen, Mofuta oa III oa collagen, le elastin, ka tsela eo, ba eketsa mahloriso a bona le letsoalo la bona letlalo la letlalo. Sena se lebisa ho plumper, ho feta voluminized letlalo. ¹
3.E thibela ho Feta Matrix Metalloproteinase Tlhaloso
Acetyl Tripeptide-1 e fetola pontšo ea lisele ho fokotsa tlhahiso e feteletseng ea matrix metalloproteinases (MMPs), ha e ntse e fokotsa ho tsoela pele matrix a extracellular ho senyeha ka ho hatella motsoako oa tsona boemong ba ho ngola.
Ho boloka collagen e teng ka mochine ona ho thusa ho boloka botenya ba letlalo le botšepehi, e eketsa nako ea tlhahiso ea collagen, ’me kahoo e thusa ho liehisa mokhoa oa ho tsofala. ²,³
4.E Ntlafatsa Mosebetsi oa ho Lokisa Letlalo la Lisele
Acetyl Tripeptide-1 e kenya tšebetsong tsela ea PI3K/Akt, molaoli ea ka sehloohong oa ho phela ha lisele, kgolo, le metabolism. Tšusumetso ena e matlafatsa ts'ebetso ea fibroblast mme e ntlafatsa tokiso ea microtrauma ea letsatsi le letsatsi.
E boetse e qhekella li-radicals tsa mahala tse hlahisoang ka tšepe-ion catalysis, ka tsela e sa tobang ho thibela khatello ea oxidative-e bakile tšenyo ea lisele le ho ntlafatsa letlalo le phetseng hantle. ⁴
COA
HPLC
MOF
