Adamax ke ntho ea maiketsetso heptapeptide nkiloeng ho ha baa ka ba utloa; tatelano e khethehileng ea amino acid ke Ac-MEHFPG-AG-NH₂.
Semax ka boeona, sekhechana sa hormone ea adrenocorticotropic (ACTH), e na le lisebelisoa tse matla tsa neurotrophic le tse matlafatsang kelello.
Meeli ea sebopeho ka har'a semax e lebisa mefokolong e kholo ho halofo ea bophelo le katleho ea ho tšela mokoallo oa mali bokong..
Ho fokotsa mefokolo ena bo-ramahlale ba ile ba hlahisa sehlopha se seholo sa adamantylacetate ka tlamahano e kopanetsoeng sebakeng sa carboxyl terminus.
Phetoho ena e ile ea ntlafala haholo thepa ea pharmacokinetic ea molek'hule ea peptide.
Kenyelletso ea moiety ena e fana ka khanyetso e haufi e felletseng ho e latelang ho senyeha ha enzyme; nako ea ho boloka mokhoa o sebetsang oa adamax ka har'a 'mele o lelefala haholo.
Ho thabisang le ho feta, ba boletsoeng pejana ‘bohlale’ moralo o khothalletsa keketseho ea ts'ebetso eo peptide e tšelang mokoallo ka eona, 'me ho finyelloa ho hlaka le ho khetha ho matlafalitsoeng.
Ho se be le ts'ebetso ea bioloji kotsing, litlamorao tsohle tse tsebahalang tsa semax li ka bolokoa kapa lia ntlafatsoa.
Tatelano
Ac-MEHFPGP-Adam-NH2
Nomoro ea CAS
/
Foromo ea limolek'hule
Setšoantšo sa C50H68N10O12S
Boima ba Molek'hule
1033.212
Patlisiso ea Adamax:
1.Matla a Phekolo le Matla a Meriana
Liteko tsa bongaka li bonts'itse Adamax ho feta Semax ho khothaletsa kholo le ts'ireletso ea boko bo nkiloeng ke neurotrophic factor (BDNF) le ho isa ntlheng boemo ba methapo ea kutlo (NGF).
Ho fetola Semax joalo ka moemeli oa kalafo, haholoholo bakeng sa mafu a kelello kapa ntlafatso ea temoho, ke ntho ea sebele e ka etsahalang.
2.Ntlafatso ea Kelello (Intelligence ho ba karolo e nyane)
Khothatso e tobileng ea taolo ea BDNF ke mosebetsi oa mantlha oa Adamax.
Ts'ebetso ea lisele tsa neuronal, moloko o mocha oa li-neurone / phapang le lintlafatso tsohle tse amanang le synaptic ke seo lipatlisiso li shebaneng le tsona hajoale.
Mosebetsi oa Hippocampal le prefrontal cortex le ona oa eketseha.
Lihlopha tsa liteko tsa nako e telele li na le li tla tsoelapele ho bonts'a, quantifiably, bokhoni bo phahameng ba ho hopola le ho ithuta.
3.Liphello tsa Neuroprotective
Ntlafatso ea kelello ea Adamax le mesebetsi e matlafatsang bohlale ha e simolohe feela ts'ebetsong ea eona e tobileng ea kholo ea lisele tsa neural., empa hape le ho tsoa ho thepa ea neuroprotective e bonts'ang.
Phokotso e sebetsang ea libaka tsa cerebral infarction ho bakuli ba stroke e bontšitsoe; ho hlasimolla le ho hlaphoheloa ha morao ha lisele tse fapaneng tsa necrotic ke karolo e 'ngoe ea bohlokoa ea ts'ireletso ena ea methapo.
Ho fokotsa excitotoxicity 'me ho fana ka litlamorao tse haufi-ufi tsa li-antioxidant lia tlatselletsa, mesebetsi e ngotsoeng hantle.
Ho ema ka hare ho sebaka sena, Adamax e na le ts'episo e ngata joalo ka moemeli oa 'nete oa kalafo bakeng sa mathata a neurodegenerative – Alzheimer ke mohlala o ka sehloohong, Parkinson o latela haufi-ufi ka morao.
4.Ho Fokotsa Matšoenyeho le Matšoenyeho
Adamax e ntlafatsa bokhoni ba motho ba ho ikamahanya le liphetoho tsa tikoloho; boko ka bobona bo tlameha ho ikamahanya le maemo ka potlako, le ho hanyetsa, mefuta e fapaneng ea khatello ea kelello ea 'mele e bakoang ke liphetoho tsena tse potlakileng tsa tikoloho.
Ho boloka mofuta o mong oa homeostasis ke sepheo sa ho qetela.
Modulation of the hypothalamic-pituitary-adrenal (HPA) axis ke ea bohlokoa ts'ebetsong ena, ho eketsa kapa ho fokotsa tokollo e nepahetseng ea li-neurotransmitters, likarabo tsohle tse fokolang tsa khatello ea maikutlo’ ho hatelloa.
Anxiolytic liphello ke molemo o ka sehloohong – ho otsela le bofokodi ba kelello (litla-morao tse haufi tsa bokahohle tsa anxiolytics tsa setso) li qojoa ka ho feletseng.
Ho ntlafatsa ts'ebetso ea kelello nakong ea mofuta ofe kapa ofe oa phomolo ea matšoenyeho ke eona e etsang hore Adamax e hohele haholo ho bafuputsi le bakuli ka ho ts'oana..
COA
HPLC
MOF
