Tetrapeptide-4 ke peptide ea maiketsetso e sebelisoang e le motsoako o sebetsang mekhoeng ea tlhokomelo ea letlalo..
E sebelisoa haholo litlolong tse thibelang botsofali, haholo-holo ho susumetsa collagen sebopeho le matrix a extracellular tlhaho, ho fokotsa botebo ba makukuno le ho eketsa ho tiya ha letlalo la letlalo.
Ka tlhaho ea eona e tsitsitseng le melemo e tsotehang ea ho thibela botsofali, Tetrapeptide-4 e fetohile e 'ngoe ea metsoako ea mantlha ea lihlahisoa tsa mehleng ena tsa tlhokomelo ea letlalo.
Tatelano
Gly-Glu-Pro-Gly
Nomoro ea CAS
960608-16-6
Foromo ea limolek'hule
C14H22N4O7
Boima ba Molek'hule
358.35
Lipatlisiso tse amanang le Tetrapeptide-4
Tetrapeptide-4 e khetholloa e le "peptide e bontšang", e leng se bolelang hore e romela melaetsa ho lisele ho e-na le ho ba karolo ea sebele ea sebopeho sa lisele.
Ketso ea eona e ka sehloohong e khahlanong le botsofali e itšetlehile ka ho tsosolosoa le ho hlokomeloa ha matrix a extracellular ea letlalo (ECM).
1.Ho tsamaisa Collagen le Elastin Synthesis
Ts'ebetso ea botsofali ea letlalo ke haholo-holo ho senyeha ha ECM ka tahlehelo e khethehileng le ho se sebetse ha collagen., elastin, le Fibronectin.
Karolo e ka sehloohong ea Tetrapeptide-4 ke ho khutlisetsa kapa ho fokotsa ts'ebetso ena ea botsofali.
Bopaki bo bongata bo tšehetsa hore Tetrapeptide-4 e eketsa ka katleho motsoako oa liprotheine tsena tse tharo tsa bohlokoa tsa sebopeho..
Ka ho susumetsa ho phahama ha maemo a bona, Tetrapeptide-4 e ka ntlafatsa haholo sebopeho sa sebopeho sa letlalo, ho fokotsa makukuno le ho etsa hore letlalo le kopane le ho reketla.
2.E hlasimolla Ho Fetola Ntlha ea Kholiso-β (TGF-β) Lokolla
Liphuputso tse ngata li hlakisa hore Tetrapeptide-4 e tlama ho li-receptors tse khethehileng tse fumanehang ka har'a lisele tsa letlalo, haholo-holo ka fibroblasts.
Tlamahano ena e kenya tšebetsong li-cascade tsa matšoao a intracellular.
Sephetho sa li-cascade tsena ke khothatso ea phetoho ea kholo-β (TGF-β) tlhahiso.
TGF-β ke e 'ngoe ea tse bohlokoa ka ho fetisisa li-cytokine e kenya letsoho ho laola motsoako oa extracellular matrix.
E bitsoa "master switch" e laolang tlhahiso ea collagen, elastin le fibronectin.
3.Ho eketsa fibronectin le glycosaminoglycan tlhahiso
E boetse e eketsa tlhahiso ea fibronectin le glycosaminoglycans ka bobeli (joalo ka asiti ea hyaluronic), e thusang hore letlalo le be le metsi haholo, e ntlafatsa ts'ebetso ea methapo, 'me e fokotsa botebo ba masoebe.
Lintlha tsa katleho mabapi le Tetrapeptide-4 li thehiloe haholo-holo ho in-vitro kapa lithuto tse nyane tsa batho tse fanoeng ke barekisi..
Ea tsena, phuputso e le 'ngoe eo hangata e boleloang ke mehloli e mengata e fana ka bopaki ba pele ba katleho.
Thutong ea bongaka, 28 baithaopi ba basali ba tsofetseng 44-66 kentse setlolo se thibelang wrinkles se nang le 60 ppm Tetrapeptide-4.
Barupeluoa ba ile ba sebelisa sehlahisoa hang ka letsatsi bakeng sa 8 libeke.
Botebo ba wrinkles bo ne bo lekantsoe ka lisebelisoa tse khethehileng le tlhahlobo ea litšoantšo tsa sefahleho.
Liphetho li bontšitse bohlokoa (leq<0.05) ho fokotseha ha botebo ba wrinkles ea periorbital le maoto a lekhoaba kamora ts'ebeliso ea tranelate ea tetrapeptide-4 ha e bapisoa le motheo.
Ho tiea le ho pota-pota ha letlalo la sefahleho li ile tsa ntlafatsoa ka mokhoa o hlakileng ho se na litlaleho tsa liphello tse sa rateheng.
Thuto ena e fana ka bopaki bo tšehetsang liphello tsa ho lokisa letlalo le ho thibela botsofali ba tetrapeptide-4.
Tetrapeptide-4 e sebelisoa haholo mefuteng eohle ea lihlahisoa tse thibelang botsofali ho tloha ho li-serum le litlolo tsa sefahleho ho isa litlolo tsa mahlo le litlolo tsa molala..
E fokotsa botebo le bophahamo ba wrinkles e tsitsitseng le e matla, ka ho toba maqeba a nasolabial le maoto a lekhoaba.
Ka nako e tšoanang, e thusa ho hlalosa lefu la tsoekere, ho fokotseha ha aterese, le ho tiisa letlalo le hlephileng ka lebaka la tahlehelo ea collagen ka mor'a ho tsofala.
COA
HPLC
MOF
