Caprooyl tetrapeptide-3 (Caprooyl-Gly-His-Lys-Ls) e matla ntlha ea kholo mimetic, e sebelisoa haholo lihlahisoa tsa litlolo bakeng sa anti-wrinkles, ho tiisa, tokiso kamora ho buuoa, le thibelo ea stretch mark.
E eme e le e 'ngoe ea tse sa tloaelehang METSI (Motsoako oa Dermal-Epidermal Junction)-ho lebisa li-peptide ka har'a lihlomo tsa hona joale tse khahlanong le botsofali tse kopanyang ts'ebetso e phahameng, botsitso bo ikhethang, le ho teneha ho fokolang.
Peptide ena e ntlafatsoa ka ho etsisa le ho ntlafatsa GHK, seqhetso se fodisang maqeba se nkiloeng ho Ho Fetola Ntlha ea Kholo. Le hoja GHK ea tlhaho e laola ts'ebetso le ts'ebetso ea Collagen VII, Laminin-5, le Fibronectin, ts'ebeliso ea eona ea bongaka e lekanyelitsoe ke halofo ea bophelo ba plasma e khuts'oane le ho boloka letlalo le futsanehileng.
E ikhethang ea N-terminal ε-amino hexanoic acid acylation ka caprooyl tetrapeptide-3 e ntlafatsa ho lumellana ha eona le motho. stratum corneum lipids ka makhetlo a 6, e ntlafatsa haholo tlhahiso ea protheine ea bohlokoa, e eketsa ho kenella ha letlalo ka makhetlo a 4, mme e ntlafatsa haholo baeloji phetisetso ea lets'oao, ka hona ho hlola mefokolo ea tlhaho ea GHK ea tlhaho joalo ka sehloho se sebetsang.
The biomimetic, mokhoa oa tlhaho oa ho lokisa oa caprooyl tetrapeptide-3 o entse hore e amoheloe ka mokhoa o pharaletseng ka litlolo tse phahameng 'me e potlakisitse haholo tsoelo-pele ea ntlafatso ea wrinkles.1
Tatelano
Caprooyl-Gly-His-Lys-Ls
Nomoro ea CAS
1012317-71-3
Foromo ea limolek'hule
C32H59N9O11
Boima ba Molek'hule
745.86
Lipatlisiso tse amanang le Caprooyl Tetrapeptide-3
1.Mekhoa ea Motheo le Katleho ea Multidimensional
Ho feta moo, sebopeho sa eona se ikhethang sa biomimetic se nolofalletsa tse ngata tse lebisitsoeng, Synergistic anti-botsofali le melemo ea litlolo. E boloka ts'ebetso ea mantlha ea peptide ea khale ea GHK-Cu, e susumetsang tlhahiso le kopano ea Mofuta oa I, III, le IV collagen hammoho le fibronectin, ha ka nako e ts'oanang e thibela ho bokelloa ho feteletseng ha matrix metalloproteinases.
Sena se lebisa ntlafatsong e kholo ea boemo ba letlalo le ho khothalletsa ponahalo ea bocha e tšoarellang. Ho phaella moo, e laola tlhophiso ea lera le ka tlaase liprotheine tsa libaka, ho matlafatsa botsitso ba DEJ le ho matlafatsa ho tiea ha letlalo ka kakaretso le mamello.
2.Khothatso ea Mosebetsi oa Collagen Synthesis
Caprooyl tetrapeptide-3 e boloka tatellano ea mantlha ea peptide ea GHK e sa feleng., e lumella hore e chelate ka katleho li-ion tsa koporo (Cu²⁺) le ho theha metsoako e sebetsang 'meleng.
Sena, ka mor'a moo, e laola tšebetso ea mongolo oa liphatsa tsa lefutso tse amanang le collagen ka har'a lisele, e susumetsang tlhahiso ea mofuta oa I le Mofuta oa III oa collagen.
E ka eketsa boholo ba collagen le botenya ka har'a dermis, ho ntlafatsa ho teteana ha letlalo le ho fokotsa mela e metle le masoebe a bakoang ke tahlehelo ea collagen.
Ts'ebetsong ea bongaka, tšebeliso ea nako e telele ea caprooyl tetrapeptide-3 e bontšitsoe ho ntlafatsa ka mokhoa o hlakileng wrinkles tse tsitsitseng tse kang li-nasolabial folds le maoto a lekhoaba.2
3.Thibelo ea Tšebeliso e Feteletseng ea Metalloproteinase ea Matrix
Caprooyl tetrapeptide-3 e hatella ts'ebetso e feteletseng ea matrix metalloproteinases e hlahisoang ke khatello ea maikutlo joalo ka ho pepeseha ha UV..
Boemong ba liphatsa tsa lefutso, e sitisa litsela tse tloaelehileng tsa ho fetisa melaetsa, ho theola tsamaiso le ts'ebetso ea interstitial collagenase le gelatin.
Sena se fana ka tšireletso e phahameng bakeng sa botšepehi le botsitso ba letlalo le teng matrix a extracellular sebopeho, ka hona ho eketsa nako ea ponahalo ea letlalo la bocha le ho fokotsa haholo ts'ebetso ea botsofali ba letlalo ho batho ba hōlileng tsebong.. 3
4.Ho Matlafatsoa ha Maqhama a Lisele tsa Dermal-Epidermal le Mosebetsi oa Barrier
Caprooyl tetrapeptide-3 e laola ho qaptjoa le ho kenya tšebetsong mofuta oa IV collagen., lamine, le Mofuta oa XVII collagen.
Sena se tiisa mokoloko oa dermal-epidermal, e ntlafatsa katleho ea phapanyetsano ea limatlafatsi lipakeng tsa lisele tsa letlalo le li-epidermal, 'me e khothalletsa likamano tse tiileng tsa intercellular.
Ka lebaka leo, e ntlafatsa sebopeho sa ts'ehetso sa kahare sa letlalo, se bakang ho tlala, sebopeho se tsitsitseng haholoanyane.
Ka kakaretso, e ntlafatsa mosebetsi oa thibelo ea letlalo, e fokotsa tahlehelo ea mongobo, le ho ntlafatsa mamello ea letlalo.
COA
HPLC
MOF
