Dipeptide-6 ke dipeptide e entsoeng ka peptide bond e hokahanyang proline (Pro) le hydroxyproline (Hyp). E nkuoa e le e 'ngoe ea likarolo tsa mantlha tsa peptide tse hlahisoang nakong ea tšilo ea lijo le ho senyeha ha collagen' meleng oa motho., e sebetsa e le biomarker e haufi-ufi ea collagen metabolism. Hydroxyproline ka boeona ke amino acid e ikhethang ho collagen; botsitso le mefuta e fapaneng ea ts'ebetso ea bioloji e amanang le dipeptide e itšetlehile haholo ka boteng ba eona – ho boloka bonyane bokhabane bo sa fellang ba letlalo e le sephetho se le seng.
Tatelano
H-Pro-Hyp-OH
Nomoro ea CAS
18684-24-7
Foromo ea limolek'hule
C₁₀H₁₆N₂O₄
Boima ba Molek'hule
228.25 g/mol
Lipatlisiso tsa Dipeptide-6
Collagen ke protheine ea mantlha ea sebopeho e fumanehang liseleng tse ngata tse hokahaneng (letlalo, masapo, lefufuru e le mehlala e meholo). Tatelano e pheta-phetoang ya sebopeho (Gly-X-Y, X/Y hape ka tloaelo Pro kapa Hyp) fa lisele tsena elasticity ea tsona e lakatsehang le matla ohle a mochine. Hydroxyproline joalokaha ho boletsoe ke hore ho hlalosa amino acid, litaba tsa eona ke pontšo ea nako ea sebele ea boemo ba 'mele ba hona joale ba metabolism mabapi le collagen.
Hydroxyproline e nang le likarolo tsa peptide ke likarolo tsa bohlokoa tsa bioactive tsa peptide efe kapa efe e nkiloeng ho collagen. – Pro-Hyp le liforomo tse amanang le tsona li ngotsoe hantle. Tsamaiso ea molomo e lumella boemo bo itseng ba ho monya, ho kena maling hore bonyane ho laole tšebetso ea fibroblast ea letlalo ka mokhoa o itseng.
Dipeptide-6 ke peptide e hlahang ka tlhaho, e tsoa ho collagen e boletsoeng. Collagen e tsoang ho liphoofolo (letlalo la tlhapi, likhomo joalo-joalo.) e ja lijo tsa motho le tsa indasteri/hydrolysis; mahlaahlela a malelele a qhalana ho ba li-peptide tse nyane, H-Pro-Hyp-OH ke e 'ngoe ea lihlahisoa tse fumanehang habonolo tsa bioactive.
Lipatlisiso ka mochine oa eona hajoale li supa litlamorao tse thibelang botsofali tsa dipeptide-6 e le tse amanang ka kotloloho le ts'usumetso ea ho ata le ts'ebetso ea fibroblast..
Ho Khothalletsa Phatlalatso ea Fibroblast le Collagen Synthesis: Li-fibroblasts ke tsona lifeme tse ka sehloohong’ boikarabelo ba ho synthesizing letlalo scaffolding le hydrating likarolo; collagen, elastin, le hyaluronic acid e le mehlala e ngotsoeng ka ho fetisisa. Mosebetsi oa bona o sebetsang o fokotseha haholo ka lilemo.
Lithuto tse ngata tsa in vitro li lula li bonts'a hore Dipeptide-6 e sebetsa hantle ho ata ha fibroblast le ho falla ho latelang.. Lipatlisiso li supa ka ho hlaka hore Dipeptide-6 e hlohlelletsa keketseho ena le kholo – mouse le letlalo la motho li-fibroblasts ka bobeli li arabela ho eona.
Ho boetse ho bonoa karolo ea chemotactic, li-fibroblasts tse hoheloang hore li tsamaele libakeng tse itseng; ho lokisa tšenyo ea letlalo le mefuta e sa tšoaneng ea ho nchafatsa lisele ho itšetlehile ka mokhoa ona.
Dipeptide-6 e bontšitsoe hore e ntlafatsa haholo ts'ebetso ea hyaluronic acid synthase ka har'a fibroblasts. E amanang ka ho toba le tse ka holimo, hydration e ntlafalitsoeng ea letlalo (motho ea penyang, ponahalo e haufi le phoka) liphello tsa tlhahiso e eketsehileng.
E sa tloaelehang, sefofu habeli, Teko ea tleliniki e laoloang ke placebo e sebelisang sebopeho se phahameng sa collagen peptide e nang le Pro-Hyp e bonts'itse ntlafatso ho hydration ea letlalo la sefahleho., elasticity, wrinkles le roughness metrics over 8 libeke.
Ho Khothalletsa Nchafatso ea ECM le Nchafatso: Ho kenya tšebetsong fibroblasts joalo ka ha ho boletsoe ka holimo, nchafatso ea ECM e sa tobang ke sephetho sa bohlokoa. Keketseho ea liprotheine tse khethehileng tsa ECM (mofuta oa I collagen e le mohlala o ka sehloohong, hammoho le elastin le fibronectin) boemong ba liphatsa tsa lefutso ho tlalehiloe.
Thibelo ea Matrix Metalloproteinase-1 (MMP-1) Tlhaloso: Tlatsetso ea molomo ea li-peptide tsa collagen e lebisa ho eketseha ha maemo a plasma ea Gly-Pro le dipeptide tsohle tse amanang; ho fokotsa UVB e susumelitsoeng ke MMP-1 ke e 'ngoe ea lintlha tse ka lekanyetsoang tsa tsela ena.
Dipeptide-6, ka mefuta eohle ea eona, ke molaoli oa 'nete oa likarolo tse ngata oa physiology ea letlalo. Botsofali ba sefahleho ke e 'ngoe feela ea melemo e mengata ea Pro-Hyp kapa dipeptide tse tšoanang.
COA
HPLC
MOF
