Hexapeptide-11 ke peptide ea bioactive eo qalong e neng e arohane le Saccharomyces ferment.. Mefuta e hloekileng e se e entsoe haholo ka lebaka la mathata a fapaneng a bohloeki. Ho laola mekhoa ea ho tsofala ha lisele, ho phahamisa matrix a extracellular tlhaho, le ho ntlafatsa ts'ebetso ea thibelo ea letlalo ke lisebelisoa tsohle tse ka bang teng; litlolo tse thibelang botsofali le ho lokisa letlalo e le tsona tse ngotsoeng ka ho fetisisa.
Tatelano
Phe-Val-Ala-Pro-Phe-Pro
Nomoro ea CAS
161258-30-6
Foromo ea limolek'hule
C36H48N6O7
Boima ba Molek'hule
676.8 g/mol
Patlisiso ea Hexapeptide-11
E le motsoako o sebetsang o thibelang botsofali, Mosebetsi oa mantlha oa Hexapeptide-11 o ho ho kenella le ho laola ts'ebetso ea botsofali e khethehileng ea lisele tsa letlalo. – dermal fibroblasts haeba ke hopola hantle. E rarahaneng, haufi le mekhoa e mengata ea ts'ebetso e ikarabellang bakeng sa sena; protheine homeostasis networks ho ba bohareng, khatello ea botsofali pele ho nako (khatello ea oxidative ke mohlala o ka sehloohong), 'me ho isa tekanyong e kholo taolo ea liphatsa tsa lefutso tsa ECM tse amehang.
Hexapeptide-11 ka boeona e khutlisetsa sena protheine homeostasis; ho kenya tšebetsong litsamaiso tsa proteasome, mefuta e fapaneng ea autophagy, le taolo e khethehileng ea motsamaisi kaofela e phetha karolo. Ho sebetsa joalo ka 'mokhatello oa tekanyo e tlase’ (mokhoa oa hormetin) e beha pele maemo sele, ts'usumetso e bonolo ea kantle e lebisang ts'ebetsong eohle e potolohileng bonyane mekhoa ea nakoana ea ts'ireletso le mofuta oa tokiso.
Ho bala “khatello ea maikutlo e bakang ho kokobela pele ho nako” ke e 'ngoe ea litlamorao tse bonts'itsoeng ka katleho. Lisele tsa senescent li phahame haholo Beta-galactosidase e amanang le Senescence (SA-β-gal kapa SABG) ts'ebetso joalo ka lets'oao le haufi la bokahohle.
In vitro e sebetsa ho sebelisoa dermal fibroblasts e pepesehileng ho li-oxidants (Hydrogen peroxide/H₂O₂ ho ba taba ea khale) e bonts'a khatello e haufi e felletseng ea keketseho e lebelletsoeng ho SA-β-Gal, ho dieha hoa mmele ho ba sephetho se hlakileng.
Tlhahlobo ea boemo ba liphatsa tsa lefutso e tiisa taolo e amanang le ECM e boletsoeng ka holimo, le litlamorao tsohle tsa boemo ba macro tseo re li bonang ka bongaka, ka tekanyo e kholo ke phello e tobileng ea liphetoho tsena tsa selefouno.
Tšebeliso ea oksijene le ts'ebetso ea metabolism le eona ea eketseha, pontšo e 'ngoe e ntle ea ts'ebetso e ntlafetseng ea lisele.
Thuto e laoloang ke placebo e kenyeletsang 25 baithaopi ba phetseng hantle ba bontšitse hore batho ba sebelisang sebopeho se itseng sa hexapeptide-11 habeli ka letsatsi bakeng sa libeke tse 'ne ba bontšitse ntlafatso e kholo ho elasticity ea pele ea letlalo le mofuta oa karabelo ea deformation.; sehlopha sa placebo se sebelitse e le ntlha e tobileng ea papiso.
E 'ngoe e tšoanang thutong ea vivo, hape le 25 baithaopi, hlahlobile serum e tiisang e nang le hexapeptide e boletsoeng ka holimo ho 2.8% (v/v) ho tsepamisa maikutlo. Litekanyo tsa lisebelisoa ka mor'a nako ea kopo ea libeke tse 'nè li bontšitse lintlafatso tse hlakileng ho seo se ka hlalosoang ka bongata e le ho tiea ha letlalo..
Hexapeptide-11 hajoale e kenyellelitsoe mefuteng e mengata e thibelang botsofali, wrinkles ke ntho eo ho amehang ka eona pele ho fokotseha. Ho tiea ha letlalo (ho isa boholeng bo itseng) ke sephetho se batloang.
Sekala se seholo, Lithuto tsa kliniki tse hlophisitsoeng hantle li ntse li hlokahala ho netefatsa ka botlalo ts'ebetso eohle e ka bang teng ea li-peptide tsena le tse amanang le tsona.
COA
HPLC
MOF
