Hexapeptide-33 (tatelano: Ser-Phe-Ls-Leu-Arg-Tyr-NH₂, SFKLRY; W3 peptide) ke peptide ea hexa-amino acid.
Ea pele e entsoe ke Novacell Technology ka laebrari ea peptide thekenoloji, Sena se etselitsoe tšebeliso ea litlolo 'me se na le melemo e mengata ea letlalo: bokhoni ba ho susumetsa angiogenesis; ntlafatsa letlalo elasticity; fokotsa wrinkles; le ho ntlafatsa mosebetsi oa thibelo.
Peptide ena e fana ka litlamorao tsa eona ka ho tlama ho G-protein e kopantsoeng le li-receptors (GPCRs) e hlahisoang haholo liseleng tsa motho, haholo letlalong keratinocyte moo e kenyang letsoho mekhoeng ea ho arohana ha epidermal.
Ke hantle ka lebaka la polokeho le katleho ea Hexapeptide-33, e fetohile motsoako o chesang lihlahisoa tse ngata tse khahlanong le botsofali / ho khantša / ho lokisa letlalo..
Tatelano
Ser-Phe-Lys-Leu-Arg-Tyr-NH2
Nomoro ea CAS
1114970-34-1
Foromo ea limolek'hule
C39H61N11O8
Boima ba Molek'hule
811.97
Lipatlisiso tse amanang le Hexapeptide-33
Mesebetsi ea likokoana-hloko ea Hexapeptide-33 hangata e etsoa ka mekhoa e latelang:
(1).Pro-Angiogenic
Ka ts'usumetso e ntlafetseng ea lisele tsa vascular endothelial, Hexapeptide-33 e potlakisa letsoalo la microvascular bakeng sa phallo e phahameng ea mali ea letlalo le lipalangoang tsa limatlafatsi..
Sena se molemo bakeng sa letlalo le omeletseng, ha e ntse e benya botsofali bo botsoa le ho potlakisa tokiso ea lisele.
E boetse e nahanoa hore e ntlafatsa matla a metabolism ea letlalo.
(2).Ho Khothalletsa Collagen Synthesis
Hexapeptide-33 e ka kenya tšebetsong dermal li-fibroblasts le ho eketsa collagen le fiber ea elastic tlhaho, ka hona ho eketsa ho tiea ha letlalo.
Likaroloana tse ling tsa hexapeptide li bile li bonts'itsoe ho eketsa polelo ea liphatsa tsa lefutso tsa collagen le ho fokotsa ts'ebetso e feteletseng ea ts'ebetso. MMPs e thusang ho diehisa ho tsofala ha letlalo.
Masalla a tatelano a nkhang hamonate, joalo ka phenylalanine le tyrosine le tsona li ile tsa fumanoa ka mokhoa o ts'oanang ho bonts'a ts'ebetso ea antioxidation ka matla a mahala a scavenging., qetellong ea fokotseha ho etsa lifoto litlamorao ka ho tima li-radicals tsa mahala ka lebaka la khatello ea maikutlo ea photooxidative.
(3).Melanin synthesis e thibetsoe
Ho lumeloa hore matla a khanyang a Hexapeptide-33 a tsoa ho bokhoni ba eona ba ho kena-kenana le ona tyrosinase mosebetsi, kapa taolo melanocyte pontsho.
Tyrosinase oxidizes tyrosine ho dopa, ebe ho ea dopaquinone joalo-joalo eumelanin.
Boholo ba li-peptide tse tšoeu li na le sebopeho sa mokokotlo se ts'oanang le li-peptide tsa tlhaho tsa tyrosinase inhibitory ho kenya tšebetsong enzyme le depigment..
Mofuta oa tyrosine moiety ea Hexapeptide-33 le bokhoni ba eona ba mantlha bo tšoanang le bona bo ka qothisana lehlokoa le tyrosinase kapa li-receptor tse amanang. (joalo ka MC1R), e lebisang ho fokotseng tlhahiso ea melanin.
(4).Pholiso ea Maqeba e Ntlafetseng le Phallo ea Lisele
Masala a amino acid a qosoang hantle joalo ka Phe-Lys-Arg a ntlafatsa tlamahano ea peptide ho membrane ea sele. li-glycosaminoglycans (mohlala, chondroitin sulfate), ka hona e lelefatsa ho bolokoa sebakeng.
Sena se eketsa ts'ebetso ea li-enzyme, joalo ka superoxide dismutase (SOTHO), e leng antioxidant mme e fokotsa ho lokolloa ha khatello ea oxidative le mabaka a ho ruruha a bakoang ke mahlaseli a UV kapa lintlha tse ling tse kantle..
Ho phaella moo, e khothalletsa ho falla ha keratinocyte le phapang ea epidermal ho ntlafatsa ho lokisoa ha mokoallo oa letlalo, e loketseng ho lokisa letlalo le senyehileng kapa le utloang bohloko.
(5).Qetello
Hexapeptide-33 e fana ka melemo e felletseng ea letlalo ka mokhoa o mosoeu oa makhetlo a mararo, Tlhokomelo ea mats'ope le mokhoa oa ho folisa Maqeba.
Hexapeptide-33 e sebelisoa: Hexapeptide-33 ke peptide e sebetsang ka bongata e ka etsoang ho ba li-serum tse ngata tse thibelang botsofali / litlolo le ho lokisa li-emulsion / limaske., dihlahiswa tse kganyang/tse felang letheba, mekhoa ea tlhokomelo ea mahlo ea premium.
Ebile e feto-fetoha haholo, e ka susumetsa tlhahiso ea collagen, lokisa tšitiso ea letlalo, thibela tlhahiso ea melanin le ho sebetsana periorbital matshwenyeho.
COA
HPLC
MOF
