Hexapeptide-9 (Hexapeptide-9, lebitso la khoebo Collaxyl™) ke peptide ea maiketsetso ea bioactive e entsoeng ka li-amino acid tse tšeletseng. Sebopeho se nepahetseng sa peptide ena se fumanoa ka har'a collagen IV le XVII ea motho; tsena li amana haufi-ufi le likarolo tsa bohlokoa tsa lera le ka tlas'a letlalo la letlalo. Biotechnological synthesized ho etsisa tse ling, haeba e se kaofela, mesebetsi ea collagen ea tlhaho, bohloeki le litaba tsa botsitso tse teng ho tse ling tsa setso’ li-extracts tsa tlhaho lia felisoa. Botsitso bo phahameng le boqapi bo bonolo bo lebisitse ho amoheloeng ha eona hohle lihlahisoa tse fapaneng tse thibelang botsofali..
Tatelano
Gly-Pro-Gln-Gly-Pro-Gln
Nomoro ea CAS
1228371-11-6
Foromo ea limolek'hule
C₂₄H₃₈N₈O₉
Boima ba Molek'hule
582.28 g/mol
Patlisiso ea Hexapeptide-9
Mekhoa e mengata ea ts'ebetso e nang le likarolo tse ngata e ngotsoe bakeng sa Hexapeptide-9. Ho sebelisoa mofuta oa mantlha oa melaetsa ea baeloji – ho kenya ts'ebetsong le ho laola mekhoa ea ho lokisa le ho lokisa letlalo.
Ho Khothalletsa Collagen Synthesis: Ho tsosoa ka ho toba ha dermal fibroblasts ke mokhoa o mong o joalo; tlhahiso e eketsehileng ea mofuta oa I le Mofuta oa IV oa collagen e le sephetho sa ho qetela. Mofuta oa I o sebetsa joalo ka ts'ehetso ea kamehla ea sebopeho e fumanehang ka har'a dermis, resilience ho ba sehlahisoa se otlolohileng. Mofuta oa IV (collagen ea lesea’ ha o ka rata) e kopanya elasticity le boreleli haholoanyane letlalong.
Ho phahama ka nako e le 'ngoe ha li-collagen tsena ka bobeli ho lebisa ntlafatsong e sebetsang ea meralo e ka tlase ea letlalo., ho fokotsa botebo ba masoebe le dintlafatso tse pota-potileng ho tiea.
Ho matlafatsa Sebaka sa Dermal-Epidermal Junction(METSI): Mona ke moo Hexapeptide-9 e ikhethelang e le kannete. Setšoantšo sa DEJ (hape, borokho bo bonahalang) bonyane e tsosolositsoe ke eona. Laminin-5 le Type IV collagen synthesis ka har'a sebaka sena ke eona e etsang hore Hexapeptide-9 e be ea bohlokoa ho basebelisi ba ho qetela..
Phetiso ea phepo, botshepehi ba sebopeho le tsohle tse latelang, ke ntoa e sa feleng khahlanong le nako le ho fokotseha.
Ho matlafatsa Letlalo Thibelo le Hydration: Ka holim'a liketso tsa eona tsa dermal, Hexapeptide-9 e potlakisa ts'ebetso ea ho lokisa epidermal. Ho tsosolosa letlalo le senyehileng (matšoao a post-acne, mefuta e fapaneng ya mengwapo, kapa esita le litlamorao tse ling tsa morao-rao tsa botle bo botle) ke e 'ngoe ea lisebelisoa tsa eona tsa bohlokoa.
Phuputso ea in vitro efficacy ka ho khetheha e bonts'itse upregulation ea ea filaggrin (FLG) lefutso; Phapang ea epidermal le ts'ebetso e latelang ea thibelo e itšetlehile haholo ka protheine ena. Filaggrin ka boeona ke selelekela sa lintho tse tsejoang e le Natural Moisturizing Factors – boteng bo eketsehileng e le sesupo se tobileng sa nako e khuts'oane le e telele ea nako e telele ea letlalo, sebaka se haufi le pheletso e phethahetseng ea ts'ireletso ea mokoallo.
Lithuto tsa bongaka li bonts'itse keketseho ea tlhahiso ea collagen ka kakaretso (ho fihlela 117% haeba ke hopola hantle) le lintlafatso tse poteletseng empa tse ka lekanyetsoang ho elasticity.
Ho feta moo, lipatlisiso li se li lebisa ho cyclic hexapeptide-9 (CHP-9) e le tharollo e ka 'nang ea e-ba e phahameng ea ho thibela botsofali. Li-peptide tsa linear tsa setso li na le sebaka sa tsona, empa sebopeho sa cyclic se fana ka botsitso bo boholo, matlafatso ea bioavailability le ts'ebetso eohle ea fisioloji.
Tšebeliso ea sehlooho ea mofuta o mong oa cyclic peptide ke mohopolo o ts'episang haholo ho thibela kapa bonyane ho fokotsa botsofali ba letlalo.. Ho netefatsa melemo eohle e boletsoeng ka holimo ka lithuto tse laoloang hantle ke mohato o latelang o utloahalang.
COA
HPLC
MOF
