Myristoyl Hexapeptide-16 ke ntho ea maiketsetso lipopeptides. Synthetically, e thehoa ka covalently conjugating myristoyl ho N-terminus ka sebopeho sa hexapeptide-16.
E tsoa ho alkaline e patiloeng ka tlhaho keratin-peptide e amanang ka hare lithapo tsa moriri, peptide ea tlhaho ka boeona e na le nako e khuts'oane ea ho boloka letlalo le ho kenella ha membrane e mpe – Khaello e rarolloang ka ho fetoloa ha lipid.
Kenyelletso ea sehlopha sa myristoyl e fana ka hydrophobic mohatla o kgonang ho kenya hara bobedi li-membrane tsa lisele le ea stratum corneum; membrane e ntlafalitsoeng haholo permeability ke sephetho se tobileng.
Tšebeliso e pharaletseng li-serum tse fapaneng tsa eyelash, lihlahisoa tse thibelang ho lahleheloa ke moriri le litlolo tse lokisoang ka mor'a ho buuoa li bontša molemo oa eona. Boemo ba eona e le ntho e sireletsehileng e laolang keratin (prostaglandin analogues e le papiso ea mantlha) ke o mong oa melemo ea eona ea mantlha.
Tatelano
Myr-Leu-Lys-Lys-Ala-Leu-Lys-OH
Nomoro ea CAS
959610-54-9
Foromo ea limolek'hule
C47H91N9O8
Boima ba Molek'hule
910.28
Lipatlisiso tse amanang le Myristoyl Hexapeptide-16
1.Mesebetsi ea mantlha ea baeloji:
Ho fana ka li-intracellular ho nolofalloa ke mafura a mafura a mahareng endocytosis tshebetso; Ntlafatso ea KRT1, KRT5 le KRT14 liphatsa tsa lefutso li khothalletsa keratin synthesis ka ho khetheha ka follicle ea moriri lisele, ho lelefatsa mokhahlelo oa anagen.
Sehlopha sa tatellano ea lys-lys ka har'a sebopeho sa sona se tlama ka tlholisano TGF-βR II, ho thibela mats'oao a phetoho ho ea ho catagen.
Lintlafatso tsa nako e le 'ngoe ka bolelele le ho teteana ha li-eyelashes le lifahleho ke liphello tse ngotsoeng.
AQP-3 le filaggrin transcript e kentsoe tšebetsong, ho matlafatsa stratum corneum tšitiso ea metsi (ho fokotsa tahlehelo ea metsi a transepidermal).
Ho hlahisa li-mediators tse fapaneng tsa ho ruruha ho fetotsoe.
2.Keratin Gene Transcript
Karolo ea mantlha ea peptide e etsisa malapa a KAP5/8, tlama ho NF-kB-joalo ka libaka tse libakeng tse khothalletsang liphatsa tsa lefutso tsa keratin.
Sebopeho sena sa keratin se ntseng se eketseha ka potlako se eketsa botšepehi le matla a shaft ea moriri.
3.Karolo e Atolositsoeng ea Anagen
Peptide ka katleho e liehisa follicular regression, ho boloka boemo ba anagen.
Ho eketsa bolelele le boima ba lintši le lintši ho bonoa, ho fokotseha ha moriri ke phello e 'ngoe ea bohlokoa; ho hōla ha moriri nako e telele ho tšehetsoa.
4.Ho matlafatsa Stratum Corneum Barrier
Myristoyl Hexapeptide-16 e tlama ho GPR40/FFA1 li-receptors ka holim'a keratinocyte, activating the cAMP/PKA tsela, CREB (CAMP Response Element-Binding Protein) haholo-holo ho ba sepheo sa ho theosa le noka; AQP-3 le mongolo oa filaggrin lia latela ka lebaka leo.
Keketseho ea lintho tsa tlhaho tse nang le moisturizing ke sephetho se tobileng, mosebetsi o betere oa stratum corneum hydration o ntse o finyelloa, ho thehoa mokoallo o sebetsang haholoanyane oa letlalo – Ka mor'a moo, tahlehelo ea metsi a transepidermal e fokotsehile.
Ho ntlafatsa letlalo la mongobo, tšireletseho e matlafalitsoeng le phokotso ea ho omella le ho ba mahoashe li bonoa; tokiso ea letlalo e senyehileng e kahara boholo ba seo peptide ena e ka se fihlelang.
5.Anti-inflammatory le Antioxidant Effects
Ho thibela litsela tse fapaneng tsa matšoao a ho ruruha (NF-κB ho ba tsela ea bohlokoa) ke e 'ngoe ea litlamorao tse netefalitsoeng, le li-cytokine tse thibelang ho ruruha (IL-6, TNF-α hara tse ding) di laolwa fatshe.
Bofubelu ba letlalo, ho teneha le matšoao a letlalo a bobebe ka kakaretso a fokotsoa ke Myristoyl Hexapeptide-16.
COA
HPLC
MOF
