Myristoyl Hexapeptide-23 (lebitso la khoebo SymPeptide® 380) ke motsoako oa maiketsetso oa peptide o kenyellelitsoeng ho pharalletseng mefuteng e fapaneng ea tlhokomelo ea letlalo. Matla a antimicrobial a mangata, le thibelo e tobileng haholoanyane ea Propionibacterium acnes, ke likarolo tse peli tsa mantlha tseo motsoako ona o lemohuoang ka tsona.
Tatelano
Myr-Ala-Lys-Lys-Leu-Lys-Leu-NH2
Nomoro ea CAS
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Foromo ea limolek'hule
C47H92N10O7
Boima ba Molek'hule
909.3 g/mol
Patlisiso ea Myristoyl Hexapeptide-23
Mofuta o fetotsoeng oa peptide ena o entsoe ka tlamahano e kopanetsoeng; tatellano ea hexapeptide e hokeletsoe ho asiti ea myristic (asiti ea tetradecanoic). The myristoyl moiety ka boeona e sebetsa e le ketane ea hydrophobic lipid, ho eketsa hydrophobicity ka kakaretso ea peptide.
Ho kenella ha letlalo le ho monya ho latelang ho khothaletsoa ka kotloloho ke thepa ena. Enjine peptide ho shebana le mathata a itseng a letlalo – makhopho ke mohlala o ka sehloohong, hammoho le maemo ohle a amanang le ho ruruha ho tsoa ho mafu a likokoana-hloko – ke karolo ea moralo oa eona.
Ka khemikhale e khethiloe e le antimicrobial peptide, tlatsetso e khahlanong le ho ruruha le ‘ho lokisa’ mesebetsi eo e e bonts'ang e feta ho bolaea baktheria feela.
Myristoyl Hexapeptide-23 e bonts'a ts'ebetso e pharalletseng e pharalletseng, P. acnes ke e 'ngoe ea libaktheria tse thibelang ka katleho.
Propionibacterium acnes e phela botebong ba mahlaku a moriri le masoba, bokahodimo bo ikemetseng, ho itšetleha ka sebum, matlakala a manyane a cellular le haufi le lihlahisoa tsa metabolic tsa letlalo le potolohileng joalo ka mohloli oa matla le limatlafatsi tse fapaneng..
Litšoelesa tsa sebaceous tse sebetsang ka tsela e feteletseng li lebisa ho eketseha (kapa bonyane bo sa laoleheng ka nakwana) tlhahiso ea sebum; ho thibela follicle ho latela. Joale baktheria ea ata, ho hlahisa liprotheine tse ngata – ho senya sebum le tsohle tse latelang, 'meleng le metabolism ho senya botšepehi ba lerako la follicle.
Ho ata ka potlako ho lebisa ho likarabo tsohle tsa ho ruruha tse boletsoeng pejana; folliculitis, makhopho a tloaelehileng, etc.
Hajoale Myristoyl Hexapeptide-23 e sebelisoa lihlahisoa tsa letlalo bakeng sa mafura, letlalo le nang le makhopho.
Lintlha tse fumanehang phatlalatsa ho tšehetsa kapa ho hanyetsa katleho ea eona ea ho phekola makhopho le maemo ohle a amanang le ona, leha ho le joalo, e ntse e haella.
COA
HPLC
MOF
