Myristoyl Tetrapeptide-12 ke peptide ea maiketsetso ea bioactive e entsoeng ka ho kopanya sehlopha sa myristoyl ka tatellano e hlakileng ea tetrapeptide.. Moralo oa sebopeho sa peptide ena o hohela khothatso e tobileng ho tsoa mochining oa myristoylation ka boeona – mofuta oa phetoho ea liprotheine ka morao ho phetolelo.
Ho tlama ha membrane ea sele e ntlafalitsoeng le phetisetso e latelang ea lets'oao ke liphetho tsa bohlokoa tsa phetoho ena ea sebopeho; lipophilicity le matlafatso a matla a membrane ea lisele le tsona lia ntlafatsoa. Ketso e sebetsang haholoanyane holim'a letlalo le follicle ea moriri lisele ke sephetho se lakatsehang.
Ho lebisitsoe tlhokomelo e kholo tšebelisong ea eona ho litlolo le mefuta e sa tšoaneng ea letlalo, phatlalatsoa ho hola ha moriri e le phello e ithutoang ka ho fetisisa.
Tatelano
Myr-Lys-Ala-Lys-Ala-NH2
Nomoro ea CAS
959610-24-3
Foromo ea limolek'hule
C32H63N7O5
Boima ba Molek'hule
625.89 g/mol
Patlisiso ea Myristoyl Tetrapeptide-12
Myristoyl Tetrapeptide-12 e oela tlas'a sehlopha sa maiketsetso ka lipopeptides; kholiso ea ho hola ha moriri ke eona ntho e ka sehloohong (mme e ngotsoe hantle) bokgoni bo ka bang teng bo batloang.
Bopaki bo tiisitsoeng ka ho fetisisa mabapi le mokhoa oa ts'ebetso bo supa taolong ea eona ea ntlha e fetolang kgolo (TGF-β)/Tsela e hlanyang. Ho ata ha lisele, karohano, apoptosis, tokiso ya dithishu – Bonyane kaofela li laoloa ke tsela ena, le potoloho ea follicle ea moriri ho se mokhelo.
Tsela ea SMAD Signaling Tshebetso: Ho laola tsela e boletsoeng ka holimo ke mokhoa oa mantlha. TGF-β ka boeona e bapala karolo e haufi e phethahetseng lits'ebetsong tsohle tse boletsoeng pejana.
Ka mor'a kalafo ka peptide, keketseho ea phosphorylated SMAD2 (le ka tekanyo e kholo SMAD3) lia shejoa. DNA e tlamang ka kotloloho ke SMAD3 ke ea ho qetela, mohato o tiileng oa taolo ea mongolo; matla a ntlafetseng a tlamang a bolela ho fetoloa (ho isa tekanyong e itseng) polelo e tlase ea lefutso.
Ho kenya ts'ebelisano ea SMAD2/3-DNA ke seo peptide e bonahalang e se etsa – liphello tsa ho hōla ha moriri e ka 'na ea e-ba phello e tobileng ea sena se ikhethang, kapa bonyane e hlalositsoe ka mokhoa o itseng, mochine.
Hair Follicle Stem Cell Regulation: Ho etsisa (kapa ho fetola) likarolo tse itseng tsa tsela e felletseng ea TGF-β, Tetrapeptide-12 le lihlahisoa tsa eona tsa ho qetela li khona ho etsa le ho li etsa, ka karolo e itseng, tsosolosa baesekele e tloaelehileng ea ho hōla ha moriri.
Mesebetsi ea mantlha ea bioloji ea setsi sa Myristoyl Tetrapeptide-12 mabapi le ho khothaletsa kholo ea moriri le ho laola metabolism ea matrix ea cellular..
Hajoale, tšebeliso ea eona e ka har'a litlolo tsa litlolo; li-serum tsa ho hōla ha li-eyelashes le mefuta e sa tšoaneng ea lihlahisoa tsa tlhokomelo ea moriri e le mehlala e ngotsoeng ka ho fetisisa.
Boithuto ba preclinical bo bonts'itse ntlafatso e kholo ea letsoalo la lintši, bolelele, le botenya e le phello e tobileng ea peptide ena.
Meetso e nang le eona (hangata hammoho le li-peptide tse ling, Myristoyl pentapeptide-17 e le mohlala o ka sehloohong) kenya tshebetsong follicle ea moriri keratinocyte, microcirculation ea lehae e le sephetho se seng se amehileng hantle – ntlafalitse ponahalo’ ea lithupa e le sephetho sa ho qetela.
Lihlahisoa tse thibelang botsofali le tsona li sebelisa peptide ena, elasticity ea letlalo le makukuno a manyane a fokotsehileng bonyane ke litlamorao tsa taolo ea lisele tsa letlalo.
COA
HPLC
MOF
