Li-oligopeptides 24 ke peptide ea maiketsetso ea bioactive e hahiloeng hantle ho tloha ho 13 masalla a amino acid.
E tsoa ho sekhechana se petsotsoeng ka enzymatic ea elastin, e na le tšebetso e ikhethang ea baeloji.
Ntlafatso e tsoelang pele, tlhatlhobo, le tatellano optimization e sebelisitsoe ho ntlafatsa eona transdermal bokhoni ba ho monya.
Ho kenyeletsoa ka boomo ea disulfide litlamo sebeletsa ho tsitsisa sebopeho sa eona.
Liphetoho tsena ha li fokotse tšebetso ea eona ea tlhaho; haele hantle, mesebetsi ea tlhaho ea protheine ea bioactive e bolokiloe haholo.
Tatelano
Cys-Met-Tyr-Ile-Glu-Gly-Gly-Gly-Gly-Arg-Gly-Asp-Gly
Nomoro ea CAS
1018685-16-9
Foromo ea limolek'hule
Setšoantšo sa C50H78N16O19S2
Boima ba Molek'hule
1271.39
Lipatlisiso tse amanang le oligopeptide-24
1.E ntlafatsa ts'ebetso ea Elastin
Ho etsisa karolo ea fisioloji ea endogenous elastin, e phahamisa haholo tlhahiso ea elastin ka hare ho letlalo la letlalo; elasticity ea letlalo, ho tiea, 'me hydration kaofela li ntlafalitsoe.
Tishu e putlamang, mela e metle e boreledi, 'me ka kakaretso liphetoho tse ntle tsa sebopeho ke liphello tse tobileng tsa mokhoa ona.
Khothatso e tobileng ea li-fibroblasts (ho ata le mosebetsi) e lebisa ho eketseha ha collagen synthesis – bophelo bo botle , letlalo la bocha ho feta ho ba sephetho sa ho qetela.
Ha o kena letlalong ka mekhoa ea ho pepa, Li-oligopeptides 24 e tlama ho li-receptor tse itseng holim'a libaka tsa fibroblast.
Letšoao la elastin lea etsisoa, ho kengoa tšebetsong litsela tsa intracellular; the sengoliloeng jini ea elastin ka boeona ke eona ntho e ka sehloohong.
Ho tiea ha letlalo le botenya li matlafatsoa haholo, ho buseletsa phokotso e ngotsoeng hantle (ho etsa lifoto) e bakang tlhahiso ea elastin ea tlhaho.
Moloko oa ‘mohloli’ liprotheine ke tsona tse khutlisetsang letlalo le tsofetseng bocha.
2.E kenya tšebetsong ts'ebetso ea Fibroblast 'me e Khothatse Collagen Synthesis
Joalokaha ho boletsoe ka holimo, ho lebisa tlhokomelo e tobileng ea fibroblasts ke e 'ngoe ea litlamorao tsa bohlokoa tsa Oligopeptide 24 e ikitlaetsa.
E ntlafatsa ts'ebetso ea metabolic ka kakaretso ea fibroblasts, ho hlohlelletsa karohano le ho ata ha bona.
E khothalletsa ho falla ka potlako libakeng tse senyehileng, ho matlafatsa boemo ba bona ba tshebetso ka ho kopanya matrix a extracellular le tlhahiso e susumetsang ea collagen ea Mofuta oa I le oa III, ho kopanya ka ho eketsehileng moralo o tiileng oa letlalo.
Matla a ho itokisa le ho tsosolosa letlalo a ntlafatsoa, se bakang ponahalo e phetseng hantle.
3.E matlafatsa Tšireletso ea Letlalo le Mosebetsi oa Hydration
Li-oligopeptides 24 e kenya tšebetsong integrin α6β4→PI3K→Akt axis, e susumetsang keratinocyte ho hlahisa filaggrin le loricrin, le ho laola polelo ea liprotheine tse thata tsa claudin-1 le occludin.
Sena se matlafatsa ka katleho botšepehi ba sebopeho pakeng tsa lisele tsa dermal le epidermal, e ntlafatsa mosebetsi oa ho nosetsa letlalo, mme e etsa hore stratum corneum hofeta.
4.Antioxidant le Ka mor'a Ts'ebetso Tokiso
Masala a Cysteine a fana ka lihlopha tsa sulfhydryl tse ka sebelisoang hape tse fanang ka lielektrone ho li-radicals tsa mahala, ho tlosa mefuta ea oksijene e sebetsang.
Ka tsela ea Nrf2/ARE, e susumetsa tlhahiso ea li-enzyme tse ngata tsa antioxidant (HO-1, SOD2, GCLC); ho thibela tšebetso ea ketane ea lipid peroxidation e hlahang mefuteng e mengata ea tšenyo ea letlalo.
Lithuto tsa bongaka li bontšitse ho fokotseha ha 'mala oa letlalo (hoo e ka bang 12%) le keketseho ya kganya ka mora ho tswelapele 8 tšebeliso ea beke.
Cysteine ka boeona e etsa li-gel tsa nakoana tse occlusive tse nang le li-aldehyde tsa mahala tse teng holim'a maqeba, ka potlako ho tiisa li-microchannels 'me kahoo ho khutsufatsa potoloho ea ho ruruha.
Phahamiso ea VEGF le TGF-β3 e khothalletsa lisele tsa granulation popeho, ha scarfibrotic TGF-β1 pontšo e boetse e thibetsoe.
COA
HPLC
MOF
