Oligopeptide-41 ke peptide e sebetsang haholo e sebelisoang ka har'a litlolo le lihlahisoa tse fapaneng tsa tlhokomelo ea moriri..
E nkiloeng ho ketsiso le optimization ea β-hairpin sebopeho se tobileng ho ntlha ea kholo ea keratinocyte(KGF), e lebile follicle ea moriri lisele tsa stem.
Ho boloka kamano e phahameng ho ea ka FGFR2-IIIb subunit ea baballoa, ka phokotso e kholo ea ho tlama ho FGFR1; ho fokotsa mitotic e boletsoeng ka holimo “e se nang moriri” litla-morao le ho atolosa halofo ea bophelo.
Litla-morao (ho hlohlona, ponahalo ea mebala ea mahlo ho ba mehlala e meholo) li qojoa haholo.
Tatelano
Ala-Ser-Ala-Lys-Trp-Thr-His-Asn-Gly-Gly-Glu-Met-Phe
Nomoro ea CAS
/
Foromo ea limolek'hule
Setšoantšo sa C63H90N18O19S
Boima ba Molek'hule
1435.58
Lipatlisiso tse amanang le oligopeptide-41
1.Mekhoa ea Ts'ebetso le Ts'ebetso
Liteko li bonts'itse peptide ena e kenya tšebetsong litsela tse peli – β-catenin/Wnt le JOANG-STAT5 – ka liseleng tsa stem tsa ORSc; ntlafatso ea polelo ea protheine e amanang le lintlha tse khahlanong le apoptotic lia latela.
Ho lelefatsa karolo ea ho hōla ha moriri oa moriri ke phello e tobileng, Ho khothaletsoa karohano ea melanocyte stem cell, ho ata ha moriri o moputsoa ho fokotsehile haholo.
Microcirculation ea lehae ea ntlafatsoa, matla a antioxidant melanocyte matlapa le hydrogen peroxide e fokotsehile.
2.Ka hona, katleho ea Triple e finyelloa
thibelo ea ho lahleheloa ke moriri, ho khothaletsa kholo ea moriri o mafolofolo, ho dieha kapa ho emisa boputsoa ka botlalo.
3.Ho Atolosa Mokhahlelo oa Anagen
Ho tlama ho li-receptor tsa FGFR2-IIIb holim'a follicular cell surface ho etsa hore ho be le dimerization ea receptor le tse latelang. phosphorylation.
Tsela ea Wnt/β-catenin e kentsoe tšebetsong, li-precursors tsa keratinocyte li lula li le boemong ba stem, karohano ea terminal e liehile.
Ex vivo Mehlala ea setso sa follicle ea moriri oa motho e bonts'itse keketseho e hlakileng le e ka lekanyetsoang ka nako le boima ba karolo ea anagen..
4.Ho kenya lisele tsa melanocyte stem le ho thibela moriri o moputsoa
Pax3 le MITF-M liphatsa tsa lefutso li laoloa.
Phapang ho melanocyte e holileng e khothaletsoa.
Liteko tsa tleliniki li tšehetsa melemo eohle e boletsoeng pejana ea Oligopeptide-41.
Ho ntse ho ithutoa mesebetsi e meng ea peptide, empa tsohle li hokahane le litsela tse hlalositsoeng pejana.
Litlamorao tse ncha tsa microcirculatory le anti-inflammatory li khahla haholo bokamoso ba moriri le letlalo.
COA
HPLC
MOF
