Name: Thymosin Alpha-1
SKU: 198889
Availability: InStock

Thymosin alpha 1 (TA-1) ke tlhaho ea 28-amino acid peptide synthesized ka hare ho thymus. E sebetsa joalo ka endogenous immunomodulator, e ntlafatsa T-cell-mediated immune immune likarabo; mekhoa e khethehileng e kenyelletsa phapang le kholo ea T cell lisele tsa pele, kenya tshebetsong ya lisele tsa dendritic le lisele tse bolaeang tsa tlhaho, hammoho le mefuta e fapaneng ea ho ruruha ha cytokine.

Ho tloha ha e sibolloa, temoho e felletseng ea thepa e matlafatsang 'mele ea Thymosin alpha 1 e thehiloe.

Tatelano

Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn

Nomoro ea CAS

62304-98-7

Foromo ea limolek'hule

C129H215N33O55

Boima ba Molek'hule

3108.28

Patlisiso ea Thymosin Alpha-1

1.Mekhoa le Mesebetsi ea Immunomodulatory

E le molek'hule ea pleiotropic immunomodulatory, ketso ea mantlha ea pharmacological ea thymosin alpha-1 ke ho khutlisa le ho ntlafatsa ts'ebetso ea 'mele ea ho itšireletsa mafung – immunodeficiency ke boemo ba bohlokoa boo e ikemiselitseng ho bo lokisa.

Ho sebetsa joalo ka agonist bakeng sa Moamoheli ea tšoanang le mohala (TLR) 9 le TLR-2 liseleng tsa dendritic (setsebi lisele tse hlahisang antigen), Thymosin alpha 1 e susumelletsa ho ikamahanya le maemo likarabo tsa 'mele oa ho itšireletsa mafung; kokoana-hloko, baktheria, mafu a fungal le mofets'e kaofela ke liphofu tse ka bang teng tsa likarabo tsena.

Ho itšireletsa ha Humoral ho boetse ho eketsoa. Ho phahamisa maemo a li-cytokine tse ngata (IL-2, IL-10, IL-12, Li-IFN ho ba mehlala e meholo) ke phello e 'ngoe e ngotsoeng hantle.

Tlhahiso e susumetsang ea li-antibody tse itšetlehileng ka lisele tsa T ke lebaka leo hangata le fanoang bakeng sa thepa ea eona ea adjuvant.

Mesebetsi e mengata ea likokoana-hloko, antitumor har'a bona, li ntse li fuputsoa.

2.Likopo tsa Clinical le Matla a Phekolo

(1)Kalafo ea Likokoana-hloko

Liteko tsa meriana li hlahlobile polokeho le katleho ea thymosin alpha 1 ka nako e telele lefu la sebete la B(HBV) bakuli. Khothatso ea ho tlosoa ha kokoana-hloko le tsosoloso ea ts'ebetso ea sebete e latela karabelo e khethehileng ea T-cell khahlanong le HBV..

Phekolo e kopantsoeng le pegylated interferon e sebetsa hantle lefu la sebete C; thymosin ka boyona kapa mmoho le interferon, e ntse e le khetho ea phekolo e sebetsang.

Li-antiviral tse sebetsang ka kotloloho li tlositse thymosin ho tsoa kalafong ea pele, empa litlamorao tse matlafatsang 'mele tsa thymosin alpha 1 tsoela pele ho ba le bohlokoa ho tsa bongaka.

(2)Ho Thibela Khōlo ea Hlahala

Lithuto tse ngata li bonts'itse ts'ebeliso e ts'episang ea thymosin alpha-1 ho bakuli ba nang le metastatic melanoma, kankere ea hlooho le molala, kankere ea matšoafo, kankere ea matsoele, le Hepatocellular carcinoma.

E sebelisoa e le pheko e tlatsetsang, e sebetsana le chemotherapy-induced immunosuppression, immunodeficiency e ka sehloohong, le mefuta e fapaneng ea maemo a immunosuppressive.

Ho kopanya thymosin alpha-1 le chemotherapy kapa radiotherapy ho bontšitse litekanyetso tse ntlafetseng tsa ho pholoha; kankere e seng e nyane ea lisele tsa matšoafo (boholo ba mefuta eohle ea kankere ea matšoafo) ho ba mohlala o ka sehloohong, ho fokola ha chemosensitivity ke e 'ngoe ea liqholotso tsa mantlha tsa lefu lena.

(3)Phekolo ea Sepsis

Thymosin alpha-1 e sebelisoa ho phekola karolo ea immunosuppressive ea sepsis.

Ho tsosolosa palo le mosebetsi oa lymphocyte – Lisele tsa T ke tsona tse ka sehloohong – e lebelletsoe ho khutlisa boemo ba ho holofala ha 'mele.

Ho hloekisa tšoaetso ea pele, ho fokotsa ts'oaetso ea bobeli e latelang, 'me ho ntlafatsa prognosis ke melemo e bonahalang ea phekolo ena.

Lithuto tsa tleliniki li tšehelitse lits'ebetso tse ts'episang, o le mong kapa mmoho le dithethefatsi tse ding.

(4)E le Mothusi oa Ente

Motlatsi oa ente ke moo thymosin alpha-1 e bonts'ang tse ling tsa litlamorao tsa eona tse tsitsitseng le tsa bohlokoa..

Likarabo tse matla tsa 'mele oa ho itšireletsa mafung ke tsa bohlokoa bakeng sa ho thibela kapa ho phekola maloetse a mangata; lefuba, AIDS, le kankere ea phekolo dikentelo ho ba mehlala e hlokomelehang.

Liente tsa ntaramane (haholoholo bakeng sa maqheku) hona joale li ntse li ithutoa ho sebelisoa setlatsi sena, ka liphello tse ntle tsa kliniki.

(5)Phekolo e Kopanetsoeng ea HIV le Meriana e Meng

Ho kopanya thymosin alpha-1 le interferon-α1 le zidovudine e ntlafatsa ts'ebetso ea 'mele ea ho itšireletsa mafung.

CD4+ lipalo lia eketseha, kokoana-hloko ea fokotseha 'me boemo ba bophelo ba bakuli ba HIV boa ntlafala.

Tsamaiso ea nako e telele ea tekanyo e phahameng ea thymosin alpha-1 e emela mokhoa oa bohlokoa oa immunomodulatory.

Thymosin alpha-1 e ntse e le immunomodulator ea 'nete ea pleiotropic e nang le monyetla o moholo oa kalafo..

COA

HPLC

MOF

(1).Poo, J. L.; SANchez-Avila, F.; Kershenobich, D.; García-Samper, X.; Gongora, J.; Uribe, M. Motsoako o hararo oa thymalfasin, peginterferon alfa-2a le ribavirin ho bakuli ba nang le lefu la sebete la C le sa foleng ba hlōlehileng pele ho interferon le ribavirin kalafo.: 24-liphetho tsa nakoana tsa beke tsa thuto ea teko J. Gastroenterol. Hepatol. 2004.

(2).Romani, L.; Bisto, F.; Gaziano, R.; Lebone la lebone, S.; Montagnoli, C.; Perruccio, K.; Sekoti, L.; Moshebelli, S.; Velardi, A.; Rasi, G.; ea Francesco, P.; Karache, E. Thymosin a 1 e kenya tšebetsong lisele tsa dendritic bakeng sa khanyetso ea antifungal Th1 ka pontšo ea receptor e kang ea Toll Mali 2004,4232-4239.

(3).Tuthill, C.; Rios, I.; Pinki, A.; Likamore tsa ho apara, R. Thymosin α1 e tsoela pele ho bonts'a ts'episo e le sentlafatso bakeng sa karabo ea ente Ann. N.Y.. Akad. Sci. 2012,21-27.

(4).Naylor, P. H.; Masekwere, K.; Karache, E.; Rasi, G.; Ho bile le, J. W. Immunopharmacology ea Thymosin α1 le Cytokine Synergy Ann. N.Y.. Akad. Sci. 2007,235-244.

(5).Sherman, K. E. Thymosin a 1 bakeng sa phekolo ea kokoana-hloko ea hepatitis C: tshepiso le bopaki Ann. N.Y.. Akad. Sci. 2010,136-140.

(6).Eckert, K.; Schmitt, M.; Garbin, F.; thetso, U.; Maurer, H. R. Liphello tsa Thymosin α1, ka vitro, ka lisele tse bolaeang tse entsoeng ka lymphokine tse tsoang ho bakuli ba nang le li-immunodeficiencies tsa mantlha: Liphetho tsa pele Int. J. Immunopharmacol 1994,1019-1025.

(7).Constantines, C.; Bellet, M. M.; Pariano, M.; Renga, G.; Stincardini, C.; Goldstein, A. L.; Karache, E.; Romani, L. Ho hlahlojoa hape ha Thymosin Alpha1 ho Phekolo ea Kankere Pele. Oncol. 2019.

(8).Li, C.; Bo, L.; Liu, Q.; Jin, F. Thymosin alpha1 e thehiloeng immunomodulatory therapy bakeng sa sepsis: tlhahlobo e hlophisitsoeng le tlhahlobo ea meta Int. J. Tšoaetso. Dis. 2015,90-96.

(9).Panatto, D.; Setsoalle, D.; Let, P. L.; Likamore tsa ho apara, R.; Rosa, A. D.; Gasparini, R. Tšebeliso ea thymosin alpha-1 (Zadaxin) joalo ka mothusi oa liente tsa ntaramane: tlhahlobo. Journal of Preventive Medicine le Hygiene. J. E fetileng. Ka. Hyg. 2015.

(10).Matteucci, C.; Grelli, S.; Batho ba hlabang metsu, E.; Motsotso, A.; Argaw-Denboba, A.; Matheba, B.; Sinibaldi-Vallebona, P.; Pin, C. F.; Mastiff, A.; Karache, E. Thymosin Alpha 1 le HIV-1: Tsoelo-pele ea Haufinyane le Maikutlo a Bokamoso Microbiol e tlang. 2017,141-155.

tlhaloso	10 mg, 5 mg

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Thymosin Alpha-1