Tripeptide-29 ke peptide ea setlolo e sebelisoang haholo ka har'a li-serum tsa motšehare., lihlahisoa tsa tlhokomelo ea ka mor'a letsatsi, le ho tsosolosoa ha lithibelo ho latela mekhoa e fapaneng ea botle ba bongaka.
E nkiloe ho cleavage ea Gly-Pro-Hyp, sekhechana sena se fokolang se emela ho pheta-pheta ho phahameng ka ho fetisisa ho fumanoang ketane ea α1 ea Kenya mofuta oa collagen; ho boloka sebopeho sa triple-helix collagen ke ts'ebetso ea eona ea mantlha ea bohlokoa.
Lithuto tsa Thermodynamic li bonts'itse sekhechana sena sa tripeptide se tsitsitse ka sebopeho, e bond ea haedrojene ea intramolecular marangrang (lesale la pyrrolidine ho sehlopha sa hydroxyl e le senotlolo) e holisa halofo ea bophelo ba eona haholo in-vivo.
Moralo o fokolang oa sekhechana ka boeona o qoba litlamorao tse amanang le liketane tse telele tsa peptide, ho feta sebopeho sa hydrophobic ho matlafatsa ho kenella ha letlalo.
Tatelano
Gly-Pro-Hyp
Nomoro ea CAS
2239-67-0
Foromo ea limolek'hule
C12H19N3O5
Boima ba Molek'hule
285.30
Lipatlisiso tse amanang le Tripeptide-29
1.Mesebetsi ea Bohlokoa ea Likokoana-hloko
Ho sebetsa ka botlalo ha ketane ea motsoali collagen α1 e bolokiloe; sesupo se sa fetoheng sea etsisoa, ho kenya tšebetsong litsela tse khethehileng tsa fibroblast tse lebisang ho collagen synthesis – tlhahiso ea collagen e ncha e le sephetho sa ho qetela, phokotso ya makukuno ke e nngwe ya diphetho tse ka lekanngwang.
Ho thibela ho bua haholo ka matrix metalloproteinases ke phello e ’ngoe e ntle, enzyme e senyang synthesis e hatelloa bakeng sa bophelo bo botle ba collagen.
Lits'ebetso tsa chain oxidation lia sitisoa, Tšireletso ea photodamage e ka sehloohong ea lik'hemik'hale tsa letsatsi e fanoa (tšitiso le hydration mesebetsi e ntse e matlafatsoa).
Taolo e sebetsang ea liketsahalo tsena tsohle tsa boemo ba limolek'hule e etsa tokiso ea 'nete ea letlalo le tsela e thibelang botsofali.
2.Ho tsosolosoa ha Collagen
Kamano e phahameng e tlamang ho TβR-III (Ho fetola sekhahla sa kholo ea beta receptor III) ke eona e khethollang Tripeptide-29; matshwao a nyeliso a etsisoa ka katleho.
E ncha, collagen e nang le molumo oa sebopeho Mofuta oa I le oa III oa collagen o kopantsoe e le sephetho se tobileng.
Tiisa, dermis e nyane haholo ke sephetho se hlokometsoeng.
3.Thibelo ea ho senyeha ha Collagen
Tripeptide-29 e hatella tlhahiso e feteletseng ea matrix metalloproteinase (MMPs) ka har'a lisele tsa letlalo.
Ho fokotseha ha litsela tse khethehileng tsa matšoao a intracellular le polelo e latelang ea lintlha tse fapaneng tsa ho ruruha ke mekhoa ea bohlokoa ts'ebetsong ena..
Ho bua ka liphatsa tsa lefutso, Polelo ea MMP e hateletsoe; tahlehelo ea marang-rang a collagen a neng a thehiloe pele e ea fokotseha.
Tikoloho e tsitsitseng bakeng sa motsoako le tlhokomelo ea collagen e ncha e fanoa.
Ho lelefatsa ponahalo ea bocha ea letlalo ke phello e ka sehloohong ea ketso ena; ho tiea ha letlalo ho bolokoa ka mokhoa ona o tsoelang pele.
4.Photoprotection le Liphello tse Khanyang
Patlisiso e bonts'a hore Tripeptide-29 e theha botenya sebopeho sa triple-helix lera le ka ntle la melanosomes.
Tyrosinase e bolokoa ho kena ka hare ho sele, tsepameng melanin tlhahiso e thibetsoeng ka tsela e joalo.
Tšenyo ea UV letlalong e fokotsehile, ho lekana ha letlalo la letlalo ka mor'a ho pepeseha nako e telele ho etsahala.
Bofubelu bo amanang le ho chesoa ke letsatsi, ho ruruha le ho chesa maikutlo ho fokotsehile haholo.
E sa foleng ho etsa lifoto matšoao ha a mpefala ka lebaka leo.
E lumellana le mefuta eohle ea litlolo tsa khoebo tsa letsatsi, photoprotection e pharaletseng e ka finyelloa.
COA
HPLC
MOF
