VIP (vasoactive intestinal peptide, PHM27)
VIP, e khuts'oane bakeng sa Vasoactive Intestinal Peptide, ke neurotransmitter ea bohlokoa le a peptide e laolang. Ho tloha ha e sibolloa, litlamorao tse matla le tse fapaneng haholo tsa fisioloji tseo e li bonts'ang li bile le karolo e kholo liphuputsong tse fapaneng tsa thuto; saense ea kelello, immunology, 'me endocrinology ke mehlala ea mantlha.
Ea pele e tsejoa ka har'a li-extracts tse nyenyane tsa mala, vasodilation e ne e le mosebetsi oa eona o neng o tsejoa qalong, 'me e ntse e le ona, ka katleho ho theola khatello ea mali. Likhatelo-pele tse ntseng li tsoela pele tsa saense li lumelletse ho tsebahatsa le ntlafatso ea mesebetsi e meng e mengata eo VIP e nang le eona..
Lipatlisiso tsa hajoale li supa hore VIP e entsoe ka methapo le ho lokolloa, e haufi le ho ajoa hohle hohle ho tsamaiso ea methapo e bohareng le ea peripheral. Ho ba teng ha VIP ho bile ho bonoa likhoele tsa methapo ea litsamaiso tse ngata – phefumoloho, tshilong ya dijo, urogenital ho bolela tse 'maloa – tsohle li bontša karolo ea bohlokoa ea neuromodulatory.
Mekhoa e mengata ea bohlokoa e laoloa ke VIP, ho ata ha lisele ho ba mohlala o le mong. Mafu a Neurodegenerative, maemo a hlobaetsang / a nako e telele a ho ruruha, mathata a autoimmune, esita le kankere – bohle ba rua molemo likopong tsa kalafo tsa VIP tsa hajoale le tse ka bang teng nakong e tlang.
Tatelano
His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2
Nomoro ea CAS
40077-57-4
Foromo ea limolek'hule
C147H237N43O43S
Boima ba Molek'hule
3326.83
Patlisiso ea VIP Peptide
1.Kakaretso ea Mesebetsi ea Multisystem Physiological ea VIP
Ka har'a tsamaiso ea methapo ka boeona, VIP e sebetsa joalo ka li-neurotransmitter tsohle; tshireletso ya methapo, mefuta e fapaneng ea ho pholoha ha neuronal le karohano tsohle tse laoloang ke eona. Morethetho oa baeloji bonyane li laoloa ka mokhoa o itseng ke VIP.
Sistimi ea phefumoloho e bona ka ho khetheha VIP e feto-fetohang bronchodilation (le tse amanang vasodilation ea matšoafo), khatello ea itseng likarabo tsa ho ruruha, ho sisinyeha ha mala, gastric tlhahiso ea acid, ho tsoa mokelikeli/electrolyte, le ho phomola ha sphincter.
Taolo le ts'ireletso e khethehileng ea Sisteme ea Methapo e Bohareng ke sebaka se khahlang haholo sa boithuto se ntseng se etsoa hajoale. Ho ithuta le ho hopola, bonyane ka karolo e itseng, li ntse li hlalosoa ka tšusumetso ea VIP.
2.Taolo ea Phefumoloho ea Bronchodilation le Liphello tse Khahlanong le Ho ruruha
Har'a mesebetsi ea eona e boletsoeng qalong, VIP e bonts'a litlamorao tse phatlalalitsoeng tsa bronchodilator le pulmonary vasodilator. Ho kenya tšebetsong li-receptor tse khethehileng ho lisele tsa mesifa tse tsamaeang ka moea le tsa methapo, e phahamisa maemo a fapaneng a tlhahiso ea lihormone; Ka mor'a moo, ho honyela ha mesifa hoa hlohlelletsoa, ka katleho ho fokotsa tse bonoang hangata khatello ea mali ea bronchial.
Liteko tsa meriana bakeng sa asthma le lefu le sa foleng la pulmonary li bontšitse VIP ho hatella haholo ho ata ho sa tloaelehang le ho falla ha lisele tsa mesifa ea tracheal.; ntlafatso ho bakuli’ boleng ba bophelo, le ho isa tekanyong e nyane tsoelo-pele ea lefu, ke phello e tobileng ea liketso tsena.
3.Taolo ea Ts'ebetso ea Ts'ilo ea lijo
E fumanoe qalong ka maleng, VIP e sebetsa joalo ka e seng adrenergic, e seng cholinergic inhibitory neurotransmitter. Ho fetola intestinal peristalsis ke e 'ngoe ea likarolo tsa eona tsa mantlha, ho phutholoha ha mesifa e boreleli ho laoloa ka hloko; lisele tsa mala a epithelial li hlohlelletsoa ho ntša metsi le li-ion tsa chloride (lubrication e le sepheo sa ho qetela), gastric acid secretion ho tloha lisele tsa parietal e boetse e thibetsoe.
Ho boloka mofuta o itseng oa tekano ka har'a tsamaiso eohle ea tšilo ea lijo ke seo VIP e ikarabellang ho sona.
4.Ho Fetola Maikutlo a 'mele
E le molek'hule oa lenģosa la bohlokoa ka har'a marang-rang a matšoao a endocrine, VIP e khahlanong le ho ruruha, antioxidant e haufi-ufi, 'me mesebetsi eohle e pota-potileng immunoregulatory e na le thahasello e kholo. Khatello ea macrophage e thehiloeng li-cytokine tsa pro-inflammatory (ho thibela ho ruruha mohloling ha ho khoneha), anti-inflammatory factor release, le ho isa ntlheng Phapang ea T-cell, kaofela ke karolo ea matla a taolo ea 'mele ea ho itšireletsa mafung a VIP.
Liteko tsa tleliniki hajoale li ntse li hlahloba bokhoni ba VIP ka mefuta e mengata ea mafu a matla kapa a sa foleng a ho ruruha.
COA
HPLC
MOF
