Selelekela:Rea u amohela ho blog ea MOL Changes.ltd! Sehloohong sena, Litsebi tsa peptide MDs li tla u fa tataiso e qaqileng mabapi le mokhoa oa ho tsosolosa phofo ea Tirzepatide, moriana oa lefu la tsoekere le ho theola boima ba 'mele[1][5]. Hore na o setsebi sa bophelo bo botle, kapa mokuli, ho utloisisa mokhoa oa ho theha peptide ea Tirzepatide hantle ho bohlokoa ho fumana molemo ho tsoa ho Tirzepatide.
Tirzepatide Peptide ke eng?
Tirzepatide ke glucagon-joaloka peptide-1 (GLP-1) agonist ea li-receptor. Ka sebopeho sa eona se tala e le phofo, e tsamaisoa ka subcutaneously ho phekola mofuta 2 lefu la tsoekere [1][2][4]le botenya[3]. Ho utloisisa mokhoa oa ho tsosolosa phofo ea Tirzepatide ka nepo ke habohlokoa bakeng sa mofuta 2 lefu la tsoekere le botenya.
Mokhoa oa ts'ebetso oa Tirzepatide ke ofe??
Peptide ea Tirzepatide ke li-agonist tse peli tsa li-hormone receptors tse tsejoang e le GIP (E itšetlehileng ka tsoekere ea insulinotropic MOL Liphetoho) le GLP-1 (glucagon-joaloka peptide-1). Li-hormone tsena li hlahisoa ka tlhaho 'meleng' me li phetha karolo ea bohlokoa ho laola maemo a tsoekere ea mali le metabolism.
E susumetsa tlhahiso ea insulin: Tirzepatide e kenya tšebetsong li-receptor tsa GIP le li-receptor tsa GLP-1, ka bobeli li fumaneha liseleng tsa pancreatic beta, ka hona, e khothalletsa ho lokolloa ha insulin. Ka lebaka la ts'ebetso ea li-receptor tsena, manyeme a ntša insulin ka lebaka la tsoekere e phahameng ea mali. Insulin e theola tsoekere ea mali hobane e thusa lisele ho monya tsoekere maling.
E thibela ho lokolloa ha glucagon: Tirzepatide e boetse e thibela ho lokolloa ha glucagon, hormone e 'ngoe e hlahisoang ke manyeme. Glucagon e phahamisa tsoekere ea mali ka ho etsa hore sebete se ntše tsoekere e bolokiloeng. Tirzepatide e emisa tlhahiso e feteletseng ea tsoekere ka ho fokotsa ho lokolloa ha glucagon.
Taolo ea takatso ea lijo le ho ntša mpa: Libakeng tsa boko tse amehang ho laola takatso ea lijo, Li-receptor tsa GLP-1 le tsona li teng. Tirzepatide e khothalletsa ho khora 'me e fokotsa ho kenngoa ha lijo ka ho kenya li-receptor tsena. Holim'a moo, GLP-1 e laola sekhahla sa limatlafatsi, ho kenyelletsa le glucose, li kenngoa maling ka mor'a lijo ka ho fokotsa ho tsoa ka mpeng.
Ho lahleheloa ke boima ba 'mele: Ketso e 'meli ea agonist ea Tirzepatide ho GIP le GLP-1 receptors e ne e amahanngoa le tahlehelo e kholo ea boima ba' mele.. Ka ho laola tšebeliso ea mafura le ho eketsa ho khora, e ka thusa ho fokotsa ho ja li-calorie le ho eketsa tšebeliso ea matla.
Tirzepatide e sebetsa ka ho kenya tšebetsong li-receptor tsa GIP le GLP-1 ho rarolla mathata a fapaneng,ho kenyeletsa taolo ea tsoekere ea mali, tlhahiso ea insulin, khatello ea glucagon, le ho laola takatso ea lijo.
Mokhoa oa ho RE kenyelletsa Tirzepatide Phofo?
Ho tsosolosoa ha phofo ea Tirzepatide e arotsoe haholo ka mehato e tsheletseng.
Mohato 1 Fumana rtikoloho e bobebe
Fumana sebaka se hloekileng le se khantšitsoeng hantle ho lokisa moriana ha u ntse u tsosolosa phofo ea Tirzepatide. Etsa bonnete ba hore bokaholimo ha bo na tšoaetso.MOL Changes
Mohato 2 Lokisetsa nhlokahala ketems
Powder ea Tirzepatide
Metsi a hloekisitsoeng bakeng sa ente
Adapter ea vial
Seringe
Mohato 3 Wmolora matsoho a hao
Kamehla hlatsoa matsoho a hau hantle ka sesepa le metsi pele u etsa phofo ea Tirzepatide ho thibela ho kenngoa ha libaktheria kapa lintho tse ling tse kotsi.
Mohato 4 Hlahisa Tirzepatide hape leqole
① Lekola vial ea Tirzepatide peptide bakeng sa matšoao a tšenyo kapa tšilafalo. U se ke ua sebelisa haeba vial e robehile kapa phofo e fetohile 'mala;
② Tlosa sekoaelo se sireletsang ho vial e nang le phofo ea Tirzepatide;
③ Hlakola sekoaelo sa rabara ho vial ka sesepa sa joala bakeng sa ho bolaea likokoana-hloko;
④ Hokela adaptara ea vial ho vial;
⑤ Ho latela litaelo, nka seringe 'me u kha metsi a hloekisitsoeng a lekaneng bakeng sa ente;
⑥ Butle-butle kenya metsi a sa hloekang ka har'a vial ea Tirzepatide peptide. Lebisa molapo oa metsi mahlakoreng a vial ho fokotsa ho phophoma.
⑦ Fetola vial ka bonolo ho kopanya metsi le phofo, u se ke ua sisinyeha ka matla;
⑧ Sheba tharollo e tsosolositsoeng bakeng sa likaroloana leha e le life kapa li-clumps, etsa bonnete ba hore phofo e qhibiliha ka ho feletseng pele o tsoela pele. Haeba mathata a fumanoa, u se ke ua sebelisa tharollo ena 'me u e lahle ka nepo.
Mohato 5 Nka tharollo e tsoakiloeng ea Tirzepatide
①Fetola vial ebe u kenya serinji ka har'a adaptara ea vial;
② Butle-butle hula plunger ho ntša tekanyo e hlokahalang ea tharollo ea Tirzeparatide;
③ Lekola syringe bakeng sa lipululo tsa moea, ha e le teng, tlanya seringe ha bobebe ho e ntsha.
Mohato 6 Tsamaiso
Kamora ho tlosa tharollo ea Tirzepatide, ente sebakeng se nepahetseng sa ente joalo ka ha o laetsoe.
Melemo ea Tirzepatide peptide ke efe?
- Khothalletsa ho theola boima ba 'mele[3][6]. Ka ho hatella takatso ea lijo, ho kgora ho eketseha, ho fokotsa ho kenngoa ha khalori, e le ho fihlela tahlehelo ea boima ba 'mele.
- Laola le ho tsitsisa maemo a tsoekere ea mali[2][4]. Tirzepatide e ka laola le ho tsitsisa maemo a tsoekere ea mali ka ho laola GLP-1 le GIP (ho fokotsa hemoglobin ea glycated (HbA1c) maemo.
- Phekolo ea mafu a amanang le botenya. Tirzepatide e ka fokotsa ka katleho mafu a amanang le botenya (tse tharo tse phahameng) le ho sireletsa tsamaiso ea pelo.
- E loketseng. Tirzepatide e hloka feela ho entoa hang ka beke, e bebofatsang bophelo ba bakuli haholo.
- Mokhoa oa tsamaiso oa fetoha. Tirzepatide e ka sebelisoa e le mong kapa le meriana e meng ea lefu la tsoekere ho sebetsa hantle.
Phello e matla ea ho theola boima ba 'mele e etsa hore Tirzepatide e khothalletsoe ke tumellano ea litsebi
Litsebi lia lumela hore botenya-haholo-holo botenya ba ka mpeng-ke kotsi e ikemetseng bakeng sa ASCVD. Ho theola boima ba 'mele ha se feela ho laola boima ba' mele, empa ka ho ntlafatsa mabaka a mangata a kotsi a ASVD ho fokotsa ho kula le ho shoa ha ASCVD. Lithethefatsi tsa antidiabetic hajoale li arotsoe ka lihlopha 4 lihlopha tse thehiloeng liphellong tsa bona tsa tahlehelo ea boima ba 'mele: e matla haholo, e matla, e itekanetseng ebile e se na phello. Litsebi li lumellana hore Tirzepatide le Semaglutide ke li-agent tse sebetsang ka ho fetisisa tsa hypoglycemic bakeng sa tahlehelo ea boima ba 'mele. Haele hantle, letoto la liphuputso tsa SURPASS ka Tirzepatide li bontšitse phello ea eona e kholo ho theoheng ha boima ba 'mele.
Lihlopha tse tharo tsa litekanyetso tsa Tirzepatide lyophilized powder (5 mg, 10 mg, 15 mg) e bontšitse phello ea ho theola boima ba 'mele ho feta lihlopha tsohle tsa taolo (ho kenyeletsa placebo kapa lithethefatsi tse laolang matla) letotong la lithuto tsa SURPASS, ka tahlehelo ea boima ba 'mele ho tloha ho 6.5% ho 13.9%. Phuputso ena e bontša hore bakuli ba nang le T2DM ba ka sebelisa meriana e sebetsang haholoanyane bakeng sa ho fokotsa boima ba 'mele. Meriana ena e sebetsa hantle ho fokotsa kotsi ea ASCVD. Holim'a moo, liphuputsong tsa morao-rao tsa SURPASS-AP-Combo tse amang batho ba baholo ba Machaena ba nang le lefu la tsoekere la T2, lihlopha tse tharo tsa litekanyetso tsa Tirzepatide le tsona li bontšitse liphello tse kholo tsa tahlehelo ea boima ba 'mele (Tirzepatide e fokotsehile 6.5% ho 9.4%; sehlopha sa taolo se eketsehile ka 2.1%) , P < 0.05), e fanang ka bopaki ba bongaka bo thehiloeng bopaking bakeng sa tšebeliso ea nako e tlang. Tumellano ea litsebi e lumela hore ASCVD e amana haufi-ufi le matšoao a mangata a metabolic (khatello ea mali, lipids tsa mali, tsoekere e maling, etc.), ntle le ho laola boima ba 'mele.
Tumellano ea litsebi e khothaletsa hore bakuli ba sa imang ba boloke HbA1c ka tlase 7.0% ho fokotsa kotsi ea ASCVD. E mabapi le tahlehelo ea boima ba 'mele. Letotong la lithuto tsa SURPASS, lihlopha tsohle tse tharo tsa litekanyetso tsa Tirzepatide li bontšitse phello e kholo ea hypoglycemic (phihlello sekhahla sa 75% ho 97%, HbA1c ea 7.0%).
MOL E fetola sethethefatsi sa ho theola boima ba 'mele Vs Setlhare sa setso sa ho theola boima ba 'mele
Traditional MOL Fetola Katleho
Lihlahisoa tse ling tse tloaelehileng tsa ho theola boima ba 'mele ha li na phello e fokolang ea ho theola boima ba' mele (joalo ka Rimonaban);
Ba bang ba khaotsa ho li sebelisa ho tla lebisa ho fokotseng boima ba 'mele(joalo ka Sibutramine).
Phello ke e tsotehang, 'me phello ea eona ea ho lahleheloa ke boima hangata e ka fihla 10%-20%;
Ha e le hantle ho ke ke ha e-ba le boima ba 'mele ka mor'a ho emisa tšebeliso.
Litla-morao tse ka 'nang tsa baka litla-morao tse kang mofetše, lefu la pelo, le tshenyo ya methapo.Jwalo ka meriana ya baeloji, e na le litla-morao tse batlang li le nyane.Mokhoa oa tsamaiso o nkuoa ka molomo le ho nooa letsatsi le leng le le leng.Ka ente 'me boholo ke hang ka beke.[7]
Mokhoa oa ho boloka phofo ea lyophilized ea Tirzepatide?
Foromo ea phofo ea Lyophilized Tirzepatide e lokela ho bolokoa ka sehatsetsing (pakeng tsa 2-8ºC). Boloka tirzepatide ka har'a sephutheloana sa pele ho fihlela e sebelisoa ho sireletsa leseli. Lipene tsa tekanyo e le 'ngoe (Mokelikeli oa ente ea Tirzepatide) e ka bolokoa mocheso oa kamore bakeng sa 21 matsatsi, ha ho hlokahala. U se ke ua hatsetsa Tirzepatide. Ho hatsetsa ho ka senya meriana le ho ama katleho ea eona. Boloka meriana ea hau feela joalo ka ha u laetsoe ke morekisi oa Tirzepatide joalo ka MOL Changes.ltd. Etsa bonnete ba hore u utloisisa ho boloka peptide ea hau hantle.
Tirzepatide phofo Tekanyetso - Mokhoa oa ho sebelisa Tirzepatide?
MOL Changes.ltd joalo ka morekisi oa Tirzepatide. Re hantle feela ho hlahisa phofo ea boleng bo holimo ea Tirzepatide. Tekanyetso ea phofo ea Tirzepatide le tlhaiso-leseling ea tsamaiso e fanoeng mona ke ea merero ea tlhahisoleseling feela mme ha ea lokela ho nkuoa e le keletso ea bongaka.. Tekanyo ea phofo ea tirzepatide lyophilized e ka fapana ho latela ts'ebeliso ea eona ea mofuta 2 lefu la tsoekere le tahlehelo ea boima ba 'mele. E ipapisitse le lithuto tse ngata, Mona ke tataiso e akaretsang ea litekanyetso tsa tirzepatide:
Tekanyo ea Tirzepatide bakeng sa Mofuta 2 Lefu la tsoekere
Tirzepatide(Mounjaro) peptide e sebelisoa e le tlatsetso ea lijo le boikoetliso ho ntlafatsa taolo ea glycemic ho batho ba baholo ba nang le mofuta 2 lefu la tsoekere mellitus. Hangata dosing e latela mokhoa ona:
Lethal dose ea pele: 2.5 mg subcutaneous ente hang ka beke bakeng sa 4 libeke.
Tekanyo ea tlhokomelo: Eketsa ho 5 mg subcutaneous ente hang ka beke ka mor'a ea pele 4 libeke.
Titration: Haeba ho hlokahala taolo e eketsehileng ea glycemic, lethal dose ka eketsoa ka 2.5 mg increments kamora bonyane 4 libeke ka tekanyo ea hona joale.
Maximum Dose: Boholo bo khothalletsoang lethal dose ke 15 mg subcutaneous ente hang ka beke.
Ka kopo hlokomela hore ea pele 2.5 mg ke ea ho qala kalafo mme ha e sebetse ho laola glycemic. U tla hloka ho fetola litekanyetso tsa hau ho latela karabelo ea hau le litlhoko tsa hau.
Tekanyetso ea Tirzepatide bakeng sa tahlehelo ea boima ba 'mele
Peptide ea Tirzepatide e bontšitsoe ho thusa ho theola boima ba 'mele ho bakuli ba batenya haholo. Tekanyo ea ho theola boima ba 'mele e ka fapana mme e ka tsebisoa ke liteko tsa bongaka tse kang SURMOUNT-1 le SURMOUNT-2.. MOL Changes.ltd e le moetsi oa phofo ea Tizepatide ha e rute mokhoa oa ho sebelisa Tirzepatide. Empa mokhoa oa ho theola boima ba 'mele o ka ba teng:
Lethal dose ea pele: 2.5 mg subcutaneous injection hang ka beke bakeng sa libeke tse 'nè tsa pele.
Keketseho e Tsoelang Pele: Eketsa lethal dose ho 5 mg beke le beke ka libeke 5-8, 7.5 mg beke le beke ka libeke 9-12, le 10 mg beke le beke ka libeke 13-16.
Phetoho e Eketsehileng: Ho itšetlehile ka karabo ea motho ka mong le mamello, nahana ka ho eketseha ho 12.5 mg beke le beke ka libeke 17-20, le ho fihlela tekanyo e phahameng ea 15 mg beke le beke ho tloha ka beke 21 ho ya pele.
Khafetsa le Nako: Fana ka liente tsa subcutaneous hang ka beke, 'me lithuto tse sebelisang protocol ena li tšoarelletse 24-72 libeke.
Ho bohlokoa ho buisana le mofani oa tlhokomelo ea bophelo pele u etsa liphetoho leha e le life ho litekanyetso tsa meriana ea hau. Tataiso ena ke kakaretso 'me ha ea lokela ho nkela keletso ea motho ka mong ea bongaka. Mofani oa hao oa tlhokomelo ea bophelo o tla etsa qeto ea mofuta o nepahetseng ka ho fetesisa oa litekanyetso bakeng sa boemo ba hau le litlhoko tse ikhethileng.MOL Changes.ltd
Lipotso Tse Botsoang Khafetsa (FAQ) FAQ
1.Q: Tharollo ea phofo ea Tirzepatide e tsosolositsoeng e lokela ho bolokoa joang?
A: Ka mor'a ho tsosolosoa, Tharollo ea Tirzepatide e lokela ho bolokoa ka sehatsetsing ka 36°F ho isa ho 46°F (2°C ho isa ho 8°C). U se ke ua hatsetsa tharollo. Tharollo e tsosolositsoeng e lokela ho sebelisoa ka hare 8 lihora
2.Q: Na Tirzepatide lyophilized phofo e ka tsoakoa le meriana e meng?
A: Che, Tirzepatide ha ea lokela ho tsoakoa le meriana efe kapa efe ka sering e le 'ngoe. Li lokela ho fanoa ka thoko ho qoba likhohlano tsa lithethefatsi.
3.Q: Ho thoe'ng haeba ke hloloheloa tekanyo ea Tirzepatide peptide?
A: Haeba u hloloheloa tekanyo ea Tirzepatide nka tekanyo e lahlehileng hang ha u e hopola, haeba ka hare 4 matsatsi ka mor'a lethal dose e lahlehileng. Leha ho le joalo, haeba e bile ho feta 4 Matsatsi a 'maloa ho tloha ha lethal dose ea hau ea ho qetela ebe u tlola lethal dose le fetotsoeng 'me u tsoelepele kemiso ea hau e tloaelehileng ea ho noa. U se ke ua kenya litekanyetso tse peli ka hare 3 matsatsi a mong ho e mong.
4.Q: Na ho na le litla-morao tsa Tirzepatide??
A: Joalo ka moriana ofe kapa ofe, Tirzepatid e ka baka litlamorao. Litla-morao tse tloaelehileng li kenyelletsa ho nyekeloa ke pelo, ho hlatsa, letšollo, le likarabo tsa sebaka sa ente. Liphetoho liphiong tsa hau (joalo ka phetoho ea bongata ba moroto), pono (joalo ka ho fokotseha/ho se bone hantle), manyeme, kapa lefu la nyooko (joalo ka ho nyekeloa ke pelo/ho hlatsa ho sa feleng, bohloko bo boholo ba mpa/ka mpeng) ke litla-morao tse tebileng tse hlokang tlhokomelo ea meriana hang-hang.
5.Q: Na phofo ea Tirzepatide e ka tsoakoa pele ho nako?
A: Che, ho kgothaletswa ho kopanya phofo ea Tirzepatide hang-hang pele e sebelisoa ho netefatsa matla a eona.
6.Q: Ke lokela ho etsa eng haeba ke sisinya vial ka phoso?
A: Haeba ka phoso u sisinya vial, e lumelle hore e lule metsotso e seng mekae ho lumella li-bubble tsa moea ho lula. U se ke ua sebelisa haeba tharollo e foams kapa e na le likaroloana tse bonahalang.
7.Q: Na adaptara ea vial e ka sebelisoa hape?
A: Che, adaptara ea vial ke ea tšebeliso e le 'ngoe feela. E lahle hantle ka mor'a tšebeliso e 'ngoe le e 'ngoe.
8.Q: Tirzepatide e lokela ho tsamaisoa ka nepo joang??
A: Ho kgothaletswa ho nka hang ka beke ho latela litaelo. E ka nkoa ka lijo kapa ka mpeng e se nang letho. E ka enteloa seropeng, mpa kapa letsoho le ka hodimo. Sebaka sa ente se lokela ho potoloha nako le nako.
Lintlha Tseo U Lokelang ho li Hlokomela
Tirzepatide ke MOL Liphetoho tse sebelisetsoang ho phekola mofuta 2 lefu la tsoekere le botenya.
Phetoho e nepahetseng ea Tirzepatide e bohlokoa molemong oa katleho ea eona.
Latela tataiso ea mohato ka mohato e fanoeng ho theha bocha
Boloka tharollo e lokiselitsoeng ka sehatsetsing 'me u sebelise ka hare 8 lihora.
Se ke oa kopanya Tirzepatide le meriana e meng ka sering e le 'ngoe.
Mokhoa oa ho reka phofo ea Tirzepatide?
O ka thabela ho reka li-Peptide tse ntle ka ho fetisisa tsa Tirzepatide ho tsoa ho barekisi ba phofo ba Tirzepatide ba hloahloa 'marakeng? U fihlile sebakeng se nepahetseng!
MOL Changes.ltd joalo ka feme ea peptide ke sebaka se setle sa ho reka peptide Tirzepatide ka litheko tsa tlholisano ho tloha ho tse nyane ho isa ho tse kholo..
Kakaretso
Tirzepatide e sebetsa haholo kalafong ea mofuta 2 lefu la tsoekere le botenya, le ho ithuta ho kopanya phofo ea Tirzepatide ke mohato oa bohlokoa ho laola bophelo ba hau ka katleho. Ka ho latela mehato ea tlhophiso e fanoeng sengolong se boletsoeng, o ka itokisetsa hantle le ho noa meriana ena.
Ho fumana lintlha tse ling:Tirzepatide
Mongoli oa sehlooho sena:
Dr. Jean Zeng o ile a qeta sekolong sa king's college london Faculty ea Life Sciences & Moriana.
Scientific Journal paper Author:
Univesithi ea Lorraine, CHRU ea Nancy, Sepetlele sa Batho ba baholo sa Brabois, lefapha la endocrinology, diabetology le phepo e nepahetseng, ke leboha Morvan, 54500 Vandoeuvre-lès-Nancy, Fora
Setsi sa Lipatlisiso sa lefu la tsoekere sa UAB, Univesithi ea Alabama e Birmingham, Birmingham, AL, usa
3,Qi Liu
Setsi sa Patlisiso ea Meriana ea Univesithi ea Wuhan, Wuhan 430060, Hubei, PR China
Lefapha la Meriana, Sekolo sa Bongaka sa Univesithi ea Koc, Istanbul 34010, kalakuni
5,Francine Mendoza B.S., Pharm.D. Mokhethoa
Harold Schnitzer Setsi sa Bophelo sa lefu la tsoekere (HSDHC), Univesithi ea Oregon Health le Science (OHSU), 3270 SW Pavilion Loop, Portland, KAPA 97239
Ho hang ngaka/setsebi sena ha se khothaletse kapa ho buella ho reka, thekiso, kapa tšebeliso ea sehlahisoa sena ka lebaka lefe kapa lefe. MOL Changes.ltd ha e na kamano kapa kamano, e boletsoeng kapa ka tsela e fapaneng, le ngaka ena. Sepheo sa ho qotsa ngaka ena ke ho amohela, amohela le ho babatsa mosebetsi o felletseng oa lipatlisiso le nts'etsopele o entsoeng ke bo-ramahlale ba sebetsang peptide ena..
Litlhaloso tse boletsoeng
[1]FDA e Amohela Novel, Kalafo e Lebisitsoeng Habeli Bakeng sa Mofuta 2 Lefu la tsoekere
[2]Mosebetsi oa Tirzepatide, Dual GIP le GLP-1 Receptor Agonist, Tsamaisong ea Mofuta 2 Lefu la tsoekere: Liteko tsa Tleliniki tsa SURPASS "
[3]”Tirzepatide e fokolitse haholo A1C le boima ba 'mele ho batho ba nang le mofuta 2 lefu la tsoekere ka mekhahlelo e 'meli 3 liteko tse tsoang lenaneong la SURPASS la Lilly” (tsebiso ea boralitaba). Eli Lilly le Khampani. 17 Hlakola 2021. E bolokiloe ho tloha qalong ho ea pele 28 Mphalane 2021. E tlisitsoe 28 Mphalane 2021 - ka PR Newswire
[4]Thomas MK, Nikooienejad A, Bray R, Hobane X, Wilson J, Duffin K, le al. (Pherekhong 2021). “Dual GIP le GLP-1 Receptor Agonist Tirzepatide E Ntlafatsa Mosebetsi oa Beta-cell le Insulin Sensitivity ka Mofuta. 2 Lefu la tsoekere“. Journal of Clinical Endocrinology le Metabolism. 106 (2): 388–396. doi:10.1210/letsoapo/dgaa863. PMC 7823251. PMID 33236115.
[5]Dahl D, Onishi Y, Norwood P, Huh R, Bray R, Patel H, Rodríguez Á (Hlakola 2022). “Phello ea Subcutaneous Tirzepatide vs Placebo E Ekelitsoe ho Insulin ea Titrated Glargine ho Taolo ea Glycemic ho Bakuli ba nang le Mofuta. 2 Lefu la tsoekere: Theko ea SURPASS-5 Randomized Clinical Trial“. JAMA. 327 (6): 534-545. doi:10.1001/jama.2022.0078. PMC 8826179. PMID 35133415.
[6]”Lilly : Mokhahlelo 3 Liphetho tsa Tirzepatide li bonts'a A1C e Phahameng le Phokotso ea Boima ba 'Mele ka Mofuta 2 Lefu la tsoekeres”. Business Insider. RTTNews. 19 Mphalane 2021. E bolokiloe ho tloha qalong ho ea pele 28 Mphalane 2021. E tlisitsoe 28 Mphalane 2021.
[7]Jastreboff AM, Aaron LJ, Ahmad NN, Wharton S, Connery L, Alves B, le al. (4 Phuptjane 2022). “Tirzepatide Hang Beke le Beke bakeng sa Phekolo ea Botenya“. NEJM. 387 (3): 205–216. doi:10.1056/NEJMoa2206038. PMID 35658024. S2CID 249385412. E bolokiloe ho tloha qalong ho ea pele 5 Phuptjane 2022. E tlisitsoe 6 Phuptjane 2022.
Boithorollo: Litaba tsa sengoloa sena ke tsa merero ea tlhaiso-leseling feela. E ka 'na ea se ke ea nepahala, e felletseng ebile ha ea lokela ho nkuoa e le ea bongaka, molao, keletso ea lichelete kapa tse ling tsa litsebi. Ketso efe kapa efe kapa liqeto tse nkuoang ho latela tlhaiso-leseling ena ke boikarabello ba mosebelisi
