Cagrilintide shine analog na amylin na dogon lokaci. Amylin peptide hormone ne wanda aka ɓoye ta pancreatic β-cell tare da insulin; daidaita ma'aunin makamashi ta hanyar gamsuwa, jinkirin zubar da ciki, da kuma hana glucagon.
Amylin da ke faruwa a zahiri, tattara a hankali kuma yana da rashin kwanciyar hankali, iyakance aikace-aikacen su na asibiti. Farkon amylin-samu analogs kamar pramlintide da ake buƙata akai-akai allura saboda suboptimal pharmacokinetics don warkewa sakamako a iri 2 ciwon sukari.
Cagrilintide yana samun wannan aikin na tsawon lokaci ta hanyar gyaran sarkar fatty acid na musamman – sau ɗaya alluran mako shine ƙarshen abin nema. Gwaje-gwaje na asibiti sun nuna tasiri mai ƙarfi na hana ci, ana nuna wani ƙarin tsarin aiki idan aka kwatanta da semaglutide.
Haɗin madaidaicin rabo (CagriSema) an bunkasa. Bayanai na asarar nauyi na gwaji na nuna haɗin ya wuce ko dai wakili shi kaɗai a cikin inganci.
Ci gaba da ci gaban cagrilintide yana faɗaɗa damar da aka ayyana a baya na amylin mimetics.; Multi-manufa synergistic magani na rayuwa cuta ne bayyanannen gaba shugabanci.
Jeri
{Eicosanedioic acid-γ-Glu}-Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Glu-Phe-Leu-Arg-His-Ser-Ser-Asn-Asn-Phe-Gly-Pro-Ile-Leu-Pro-Thr-Asn-Sn-Pro-Thr-Asn-Sn-Pro-H (Disulfide gada:Cys3-Cys8)
Lambar CAS
1415456-99-3
Tsarin kwayoyin halitta
Saukewa: C194H312N54O59S2
Nauyin Kwayoyin Halitta
4409.01 g/mol
Bincike mai alaƙa da Cagrilintide
1.Ciwon Ciki da Ƙarfafa Koshi
A matsayin analog na amylin, saurin ketare shingen kwakwalwar jini shine mabuɗin tasirin Cagrilintide.
Niyya kai tsaye na takamaiman yankuna na kwakwalwa waɗanda ke daidaita tsantsar yunwa’ shine abin da ya bambanta shi – kunnawa na mai karɓa na calcitonin (sigina isashen makamashi) yana ragewa, idan ba ya kawar, sha'awar abinci ta tsakiya.
Tsarin abinci mai ƙarfi na son rai ba zai iya kwafin wannan canjin ilimin halittar jiki zuwa wurin saita mutum ba.
2.Jinkirta a zubar da ciki da duk narkewar na gaba
Hana raunin tsoka mai santsi na ciki da shakatawa na pylorus yana ba da ƙarin nau'i na ci gaba na jiki..
An rage sha mai gina jiki, postprandial glucose jini (kuma zuwa babban adadin duk sigogi na rayuwa) ana kiyaye su kamar yadda zai yiwu.
3.Yana hana fitowar glucagon postprandial
Glucagon shine hormone wanda ke inganta hanta glycogenolysis kuma gluconeogenesis; yadda ya kamata hidima a matsayin a hyperglycemic wakili.
Cagrilintide yana kwaikwayi takamaiman sirrin sirrin postprandial wanda alpha Kwayoyin yi, sigina ta hanyar tsarin jijiya na kwakwalwa cewa wannan sakin ya faru.
Mahimman raguwa a cikin abin da aka ce asirin shine sakamakon ƙarshe – rage yawan glucose na jini bayan cin abinci yana daya daga cikin fa'idodin farko.
Inganta tsarin abinci don nau'in 2 masu ciwon sukari suna da alaƙa da wannan tsari; cinye nau'ikan makamashi iri-iri’ ana iya tuntuɓar ta tare da cikakkiyar amincewa ta kusa ba tare da saka idanu na glucose akai-akai ba.
4.Ayyukan Haɗin kai tare da GLP-1 Mai karɓar Agonists
Ana nuna hanyoyin haɗin kai sosai tsakanin cagrilintide da waɗannan agonists.
GLP-1 kanta yana mai da hankali sosai akan satiety, yayin da amylin analogues (zuwa kusa da cikakken iyaka) danne duk wani nau'i na yunwa.
Hanya biyu, masu yawan niyya pathophysiology tushen tsarin kula da kiba da ciwon sukari shine abin da haɗin ke bayarwa.
Nazarin (CagriSema shine mafi kwanan nan) sun nuna babban asarar nauyi da ingantaccen sarrafa glycemic lokacin da aka yi amfani da su tare.
COA
HPLC
MS
