Da Mazduts,A madadin aka sani da IBI362 ko LY3305677, wani sabon dual agonist niyya duka biyu glucagon-kamar peptide-1 mai karɓa (GLP-1R) da kuma glucagon receptor (GCGR). Yin hidima a matsayin wakili na anti-kiba, yana rage nauyin jiki, glucose na jini,hawan jini, da tarin wasu matsaloli masu nasaba da kiba.
An gina haɓakar wannan fili akan ƙarin zurfin fahimta oxyntomodulin's physiological rawar; Hormone na hanji na halitta wanda ke da GLP-1 dual dual da ayyukan glucagon. Mazdutide ita kanta analog ce ta roba wacce aka samo daga oxyntomodulin, tare da tsawo mai acyl sassan sassan da aka kera musamman don tsawaita lokacin aikin (yana ba da damar yin allurai sau ɗaya a mako).
Bayan sauki nauyi asara, bincike ya nuna yana kara kuzarin insulin (cikin mice), saukarwa uric acid matakan, inganta oxidative danniya, kuma aƙalla wani ɓangare yana rage wasu cututtukan koda.
Jeri
Nasa-{Aiba}-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Glu-Lys-Lys-Lys-Ala-Lys-{AEEA-AEEA-γGlu-Nonadecanoic acid}-Glu-Phe-Val-Glu-Trp-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-NH2
Lambar CAS
2259884-03-0
Tsarin kwayoyin halitta
Saukewa: C209H319N45O68
Nauyin Kwayoyin Halitta
4563.06
Binciken Mazdutide
1.Rage Nauyi da Ciwon Ciki
Nazarin mako 12 ya kimanta canje-canje a cikin sha'awar abinci da nauyin jiki a cikin berayen da aka gudanar da taro daban-daban na mazdutide..
Mahimmanci, An lura da raguwa-dogara a cikin nauyin jiki, tare da mafi girma allurai zama mafi tasiri.
Sassan histological na hanta sun ba da ƙarin goyon baya ga wannan sakamako – Hepatic steatosis da kumburin da ke tattare da su an rage su sosai.
Mazdutide-HD (mafi girman nau'in kashi) ya nuna mafi ƙarfi tasirin hanta idan aka kwatanta da dulaglutide.
2.Ingantattun Ayyukan Mota da Halayen Bincike
Masu bi 30 kwanaki na ci gaba da gudanarwa, berayen da aka yi musu magani tare da mazdutide sun nuna ingantaccen iyawar koyo akan rukunin kulawa, tare da ingantaccen tasiri fiye da dulaglutide.
Gwaje-gwajen rashin fahimta suna tallafawa yuwuwar tasirin warkewa na mazdutide akan aikin fahimi.
3.Ingantattun Haɗin Motoci, Ma'auni da Halayen da suka danganci Damuwa
Gwajin ma'auni na ma'auni ya nuna beraye suna gudanar da mazdutide don zama mafi kyau sosai (ƙetare lokaci da ƙimar nasara) fiye da sarrafa beraye.
Gwaje-gwaje masu alaƙa da fahimi da damuwa suna ƙara tallafawa waɗannan sakamakon.
4.Ingantawa da Gyara Lalacewar Jijiya da Mutuwa
The hippocampus yana da hannu sosai a cikin koyo da ƙwaƙwalwa; aikin fahimi yana da alaƙa da waɗannan hanyoyin.
Binciken tarihi na sassan neuronal na hippocampal da suka lalace ya nuna cewa Mazdutide aƙalla yana rage wannan nau'in asarar neuronal..
An kuma lura da adana reshen dendritic da ma'auni daban-daban na yawan kashin baya a cikin yankin hippocampal.; ƙarin takamaiman tasirin neuroprotective da aka gani a cikin CA1(Kahon Ammon 1) da CA3(Kahon Ammon 3) subfields kasancewa na musamman sha'awa.
5.Hana Rage Myelin
Myelination kanta tana taka muhimmiyar rawa a cikin koyan mota, amsoshi masu daidaitawa ga kowane nau'ikan alamomin azanci ta hanyar ra'ayoyin muhalli akai-akai.
Cikakken rufin axonal da kuma babban tallafin abinci mai gina jiki don aikin tsarin jijiya ana samarwa ta myelin.
Myelin remodeling (tsarin da ke da alaƙa da alaƙa da myelation na gaskiya) shine kuma ya kasance muhimmin al'amari na manya CNS(Tsarin Jijiya ta Tsakiya) lafiya.
LFB(Luxol Fast Blue) tabo ya bayyana demyelination na kashin baya; Ƙungiyar mazdutide ta nuna mafi kyawun tsarin myelin sheaths, ƙarancin demyelination mai tsanani shine sakamakon kai tsaye na jiyya.
Kiyaye mutuncin myelin yanzu ana ɗaukarsa a matsayin manufa mai yiwuwa – jinkirta farawa da jinkirin ci gaba na Cutar Alzheimer kasancewa ɗaya daga cikin maƙasudin warkarwa na irin wannan bincike.
COA
HPLC
MS
