Glycosylation, dị ka ihe dị mkpa post-translational mgbanwe nke protein, nwere mmetụta dị ịrịba ama na njirimara nke protein dị ka nhazi, nkwụsi ike, antigenicity na immunogenicity. Agbanyeghị, Ụzọ ndị a na-emekarị maka nkwadebe nke N-glycosylated peptides na-adaberekarị na nhazi nke njikọ amide., usoro nke acidic ma ọ bụ otu ndị na-arụ ọrụ nwere ike igbochi ya, si otú ahụ na-amachi ngwa ha. Iji merie ihe ịma aka a, atụmatụ ọhụrụ - mmeghachi omume mgbakwunye Giese nke ahọpụtara saịtị nke photoredox mere ka emepụtara iji nweta nkwadebe nke peptides N-glycosylated..
Ọganihu teknụzụ
E mepụtara ihe ọkụ ọkụ a na-ahụ anya iji ghọta mgbanwe glycosylation nke peptides n'okpuru ọnọdụ dị nro..
Na-emebi oke nke ụzọ ọdịnala na ndị na-enye onyinye glycosyl na ihe fọdụrụ na amino acid, Achọpụtara njikọ ziri ezi nke otu glycosyl dị iche iche na peptides.
Ewubela ikpo okwu dị mma ma na-agbanwe agbanwe maka mgbanwe fotocatalytic peptide glycosylation., na-enye ngwá ọrụ dị ike maka njikọ nke glycopeptides dị mgbagwoju anya.
Uru nka
- Mmeghachi omume bụ nke ukwuu saịtị-ahọrọ na orthogonal, nwere ike imepụta peptides N-glycosylated nke ọma.
- Ike ịgbanwe peptides dị mgbagwoju anya sitere na protein ndị sitere n'okike, gụnyere peptides na-arụ ọrụ ndụ yana ọgwụ peptide.
Teknụzụ mgbanwe fotocatalytic peptide glycosylation na-enye ngwọta ọhụrụ maka njikọ ziri ezi nke glycopeptides., nke nwere nnukwu uru sayensị na uru ngwa. Mmepe nke teknụzụ a ga-akwalite ọganihu na ngalaba nke glycobiology, nchọpụta ọgwụ na sayensị ihe, n'etiti ndị ọzọ.
