Cardiogen bụ peptide bioactive na-emepụta ihe na-egosipụta mmetụta nchebe obi yana ikike mweghachi. E sitere na nyocha mmadụ na-aga n'ihu n'ime pathogenesis nke ọrịa obi, ọ bụ ọgwụ peptide emepụtara nke ọma.
Nchedo obi, ma ọ bụ karịa sara mbara mgbochi obi n'ime ihe ndị dị ndụ, na-agụnye nnyefe nke ụzọ mgbaàmà kpọmkwem; homonụ na neurotransmitters bụ ndị ogbugbo mbụ.
Emebere Cardiogen site na mmalite ka ọ ṅomie ụzọ ndị a ma ọ bụ mee ka protein mgbama isi mgbada ozugbo(s) iji nweta nchebe kwuru.
Ọbụghị ọgwụ ewepụtara na okike, njedebe niile dị n'ime ya metụtara peptides eke (nbibi ngwa ngwa, obere ọkara ndụ, ala bioavailability) na-emeri n'ókè dị ịrịba ama.
Ọmụmụ ihe izizi egosila mbelata dị ukwuu na myocardial infarct nha, emelitere ọrụ ventricular aka ekpe, mgbochi nke oghom nhazigharị ventricular, na nchebe megide ma apoptosis na necrosis nke cardiomyocytes.
A na-egosipụtakwa ikike antioxidant dị ike, na-ebelata ụdị ọ bụla nke mmebi oxidative kpọmkwem na nke ọ bụla cardiomyocytes ma ọ bụ sel endothelial vaskụla na-eso ya.
Nnyocha e mere n'oge na-adịbeghị anya na-ekwu maka ịkwalite ume ike myocardial – njikarịcha ọrụ mitochondrial na mmepụta ume bụ nke nwere mmasị pụrụ iche.
A na-enyocha mmetụta mgbochi fibrotic ugbu a.
Multidimensional, synergistic cardioprotective na ike ọgwụgwọ bụ ihe Cardiogen na-anọchi anya ya.
Usoro
Ala-Glu-Asp-Arg
Nọmba CAS
/
Usoro ihe omimi
C18H31N7O9
Ibu molekụla
489.486
Nnyocha nke Cardiogen Peptide
1.Ịgwọ ọrịa obi na ụdi mmerụ ahụ reperfusion
Mmeri nkwụghachi azụ n'onwe ya bụ njedebe nke ọtụtụ ndị na-achọ ọgwụgwọ ugbu a.
Ihe mgbochi n'ime sistemu obi na-eduga na ischemia/hypoxia nke myocardium; kpọmkwem mweghachi nke ọbara eruba (ịwa ahụ ma ọ bụ nke ọzọ) na-akpata nnukwu mmebi a.
cardiogenic, site na ịgbalite ụzọ intracellular a kpọtụrụ aha na mbụ (PI3K-Akt ịbụ onye isi n'etiti ha), na-eṅomi nzaghachi nchebe endogenous nke anụ ahụ.
Mmepe nke mitochondrial permeability mgbanwe pore(mPTP) ịbụ otu n'ime ndị ikpeazụ, nzọụkwụ na-emebi adịghị agbanwe agbanwe na ọnwụ cardiomyocyte, na-egbochi nke ọma.
Napụta onye ọrịa site n'uju ma ọ bụ nso zuru oke infarction bụ ezigbo ọgwụgwụ N'ihi – ntakiri, ọzọ 'nkịtị’ nnukwu myocardium na ihe niile na-esote, bụ ezi ebumnuche ọgwụgwọ cardiogenic.
2.Na-egbochi apoptosis
N'ụdị nke nrụgide obi na-adịghị ala ala yana mmerụ ahụ reperfusion, E gosipụtara cardiogen iji gbochie apoptosis nke ukwuu.
Ha na-arụ ọrụ igodo ozugbo kinases dị ka Akt, na-egbochi ọrụ protein pro-apoptotic site na phosphorylation, na n'ọnọdụ ụfọdụ kwalite ọrụ protein anti-apoptotic.
A na-enweta ụdị nkwụsị nke ọkwa hormonal kpọmkwem nke apoptosis site na usoro ndị a.
Nchọpụta a na-egosi ikike dị ukwuu maka cardiogen – ịnapụta ndị ọrịa obi na-arịa oke njọ bụ otu ngwa, na-achịkwa akụkụ dị iche iche nke ọrịa obi na-adịghị ala ala, na-eji nwayọọ nwayọọ (ọ bụrụ na ọ naghị akwụsị) mbelata nke sel myocardial, na site na ndọtị na-egbu oge ụdị nile nke nkụda mmụọ obi na-aga n'ihu.
3.Na-emeziwanye ike nke obi metabolism
Cardiogens na-akwalite metabolism ike n'ime sel obi; Mgbochi n'ihu njedebe nke oghere mPTP bụ ụzọ bụ isi eji eme ihe maka nke a.
Mbelata mmebi oxidative na agbụ ụgbọ njem mitochondrial elektrọn na-enye ohere ka mitochondria jikwaa ma ikike akpụkpọ ahụ yana ruo n'izi ezi n'ọkwa dị ukwuu..
Oru oma adenosine triphosphate (ATP) mmepụta ga-ekwe omume, ụdị ume na-adigide mgbe nile na-enye obi nke dara ada.
Nkwekọrịta obi kwụsiri ike na ụdị niile metụtara ọrụ obi dị mkpụmkpụ/ogologo oge dabere na ike a kwụsiri ike.
4.Antioxidant na mgbochi mkpali mmetụta
cardiogen na-egosipụtakwa mmetụta antioxidant na-apụtaghị ìhè.
Nkwalite ozugbo nke ụfọdụ ụzọ mgbaàmà (Akt ịbụ isi ihe atụ) na-eduga n'ịhazi usoro antioxidant endogenous nke anụ ahụ.
Glutathione peroxidase na ndị ọzọ yiri enzymes na-ahụ ụba okwu, eke ọzọ 'mma’ gburugburu ebe obibi maka mkpụrụ ndụ obi.
Mgbochi nke myocardial fibrosis na imegharị ventricular: Fibrosis obi n'onwe ya bụ isi ihe na-ebute nnukwu ọrịa obi ma ọ bụ ọdịda akụkụ ahụ.
Mgbakasị ogologo oge na-akpata fibrosis na nhazigharị ventricular na-esote bụ ma ọ dịkarịa ala na-akpata njedebe njedebe nke ọrịa obi..
Omume cardiogen na ihe ndị a kpọtụrụ aha n'elu (mgbochi apoptotic bụ isi) na mgbochi kpọmkwem nke pro-fibrotic akara, bụ mpaghara nchọcha dị oke mkpa na edekọ nke ọma.
Ikike nke Cardiogen igbu oge ma ọ bụ gbochie fibrosis myocardial bụ akụkụ nke nkwa ọgwụgwọ ya n'ozuzu ya..
COA
HPLC
MS
