Dihexa bụ ọhụrụ oligopeptides bioactive peptide kpọmkwem e mere maka ọgwụgwọ nke ọrịa neurodegenerative.
Mbụ kọrọ na 2012, ọ sitere na nchọgharị na ụdi reverse engineering nke angiotensin IVMmetụta 'n'ụzọ dị iche iche nke ụbụrụ ụbụrụ endogenous.
Nhazi molikula na-abụghị nke okike nke Dihexa na-eme ka nhọrọ mkpụrụ ndụ dị iche iche kwupụta saịtị ebumnuche; Achọpụtala mmụba dị ukwuu na nkwụsi ike nke metabolic, ike onu bioavailability na elu Central ụjọ penetration bụ abụọ n'ime ya ndị ọzọ pụtara ìhè àgwà.
Na-eje ozi dị ka onye na-arụ ọrụ nke ọma ma dị ike c-Met agonist receptor, akụkụ niile nke mmepe sistemu ụjọ nke etiti, ịrụzi na ruo n'ókè dị ukwuu ọhụrụ, a na-akwado ya.
Usoro
Hexanoyl-Tyr-Ile-Ahx-NH2
Nọmba CAS
1401708-83-5
Usoro ihe omimi
C27H44N4O5
Ibu molekụla
504.67
Nnyocha nke Dihexa Peptide
1.Enwere ike ịgwọ ọrịa na usoro nke ime ihe
Ịkwalite ikike mmụta na ikike ncheta bụ otu n'ime mmetụta dị mma a na-ahụ anya ozugbo.
Mmebi neuronal site n'ọtụtụ ihe – nrụgide oxidative, β-amyloid (Aβ) toxicity metụtara ya, mitochondrial dysfunction – nwere ike igbochi Dihexa.
Ngwa usoro iwu maka ịgwọ ọrịa dị iche iche nke degenerative neurological (Ọrịa Alzheimer, Ọrịa Parkinson, Huntington bụ ezigbo ihe atụ) soro usoro nyocha a.
Oligodendrocyte precursor cell iche, myelin metụtara regeneration, Ọbara cerebral/mkwalite ike na-enye ike na n'ókè ụfọdụ mgbochi tumor bụ ihe akaebe dị ugbu a kwadoro..
Enwere ike dị ukwuu maka Dihexa dịka onye na-ahụ maka ọgwụgwọ.
2.Ịkwalite mmụta na ebe nchekwa
Sistemụ HGF/Cmet bụ isi ihe na-akwalite mmepe hippocampal.
Na nnwale maze, otu Dihexa gosipụtara ikike mmụta siri ike karị; ịchọta nyiwe zoro ezo, ha mere nke a n'oge dị mkpirikpi karịa ndị njikwa.
HGF-Tg otu n'onwe ya gosiri ma elu izi ezi na nkwalite mmụta nnọgidesi ike.
Tụnyere njikwa ụdị anụ ọhịa, mmụba nke okwu HGF mere ka ịrị elu doro anya na sel nnabata hippocampal – ịkwalite mmụta na ebe nchekwa bụ otu n'ime mmetụta dị mma a na-ahụ anya.
3.Na-akwalite Synapsis na Dendrite Formation
Dị ka a ihe na-eto eto hepatocyte (HGF)/c-Met agonist receptor, Dihexa na-eme ka ụzọ mgbama dị iche iche rụọ ọrụ (PI3K/Iwu ịbụ onye isi, MAPK/ERK nke abụọ), ozugbo ikwado ọhụrụ synapse na ruo n'ókè dị ukwuu dendrite nhazi n'ime neurons.
Ọnwụ Dendrite bụ isi ihe na-akpatara ụdị ọ bụla nke ọdịda ebe nchekwa na-adịgide adịgide; nsogbu mmụta na-esochi anya.
Nnwale anụmanụ na-arụtụ aka na Dihexa nwere ezi ike ọgwụgwọ maka ọrịa Alzheimer.
4.Neuroprotection na mgbochi apoptosis
Ọrịa Neurodegenerative na-aga n'ihu site n'ọtụtụ ụzọ – nrụgide oxidative, ụdị dị iche iche nke mitochondrial dysfunction, na njedebe nke ihe na-adịghị mma nchịkọta protein na-eduga na neuronal apoptosis.
Dihexa, site n'ịkwalite usoro HGF ahụ e kwuru n'elu, na-akwụsị usoro a nke ọma; na-egbochi (ma ọ bụ na-egbu oge) nnyefe zuru oke nke akara apoptotic bụ akụkụ dị oke mkpa nke ọrụ neuroprotective ya.
5.Na-akwalite myelin ọhụrụ
Myelin bụ n'ọbọ abụba na-ekechi ya axon nke neuron, nnyefe mgbaàmà akwara ziri ezi na ngwa ngwa dabere na ya.
Ọrịa ụkọ Myelin na-eduga n'ụdị arụ ọrụ akwara ozi niile.
Oligodendrocyte precursor cell (na ruo n'ókè, sel akwara niile) enwere ike kpalie iji kwalite myelin ọhụrụ, na Dihexa nwere mmetụta doro anya ma dị mma na usoro ụjọ ahụ n'ozuzu ya.
COA
HPLC
MS
