Hexapeptide - 10, ma ọ bụ karịa ka akpọrọ SIKVAV/Serilesine, bụ nkeji ọrụ kacha nta dịpụrụ adịpụ na ngalaba globular nke lamini α1 yinye. Ọrụ ndu dị elu pụrụ iche bụ njirimara nke peptide a.
Ọmụmụ ihe mbụ egosila ka ukwuu cell adhesion-na-akwalite na, ruo n'ókè dị ukwuu, ike na-akpali akpali axonal ma e jiri ya tụnyere laminin na-adịghị. Specific nnabata na ụdi ebighị nke dị iche iche ihe integrin na ndị ọzọ elu anabata bụ ihe ọzọ isi ihe; mmụba cell, iche, na nlanarị niile na-eso dịka nsonaazụ ozugbo.
N'ime neuroscience, ike ọgwụgwọ maka ịrụzi mmebi nke etiti ma ọ bụ mpụta ụjọ usoro edewo nke ọma. Ogige ịchọ mma ahụla n'oge na-adịbeghị anya ịrị elu dị ịrịba ama na ama ama ya.
Hexapeptide - 10, nyere ya neuromodulatory na ikike imezi anụ ahụ, bụ akụkụ dị mkpa nke ma ịchọ mma na dermatological sayensị.
Onye ahịa nwere obi ụtọ, onye nrụpụta adipiscing ga-achụ ya. Dị ka onye mmepụta nke ala, mwute, ma ọ bụ corporal nke ihe onwunwe, ohiri isi protein.
Usoro
H-Ser-Ile-Lys-Val-Ala-Val-OH
Nọmba CAS
146439-94-3
Usoro ihe omimi
C28H53N7O8
Ibu molekụla
615.77
Nnyocha metụtara Hexapeptide-10
1.Ndozi akpụkpọ anụ na iwu homeostasis
Nnukwu grafting ma ọ bụ ngbanwe elu nke biomaterials na Hexapeptide-10 na-enye ohere maka ntinye nke cell cell iche, fibroblast/endothelial mmụba cell na mbugharị eduzi – si otú accelerating akpụkpọ ọnya ọgwụgwọ.
Usoro ziri ezi nke keratinocyte mmụba-iche itule bụ ihe na-ekewa ya iche; A na-emeziwanye mmụba nke basal oyi akwa epidermal, na-akwalite nkewa n'usoro nke stratum corneum.
A na-emeziwanye ike nhazi akpụkpọ ahụ yana iguzosi ike n'ezi ihe n'ozuzu ya, udidi bụ isi nchegbu. Ụzọ nrịbama akwara na-modulated, ibelata mmetụta anụ ahụ na mkpali mpụga; akpụkpọ anụ dị nro karịsịa na-erite uru site na ihe niile dị n'elu.
2.Na-achịkwa mmụba nke keratinocyte na ọdịiche dị iche iche iji nọgide na-enwe homeostasis anụ ahụ
Hexapeptide-10 na-arụ ọrụ ozugbo na sel epidermal, na-emeziwanye mmụba ha na ihe dị iche iche na-esote.
Na-egbochi ndịiche na-adịghị mma na nkewa na-achịkwaghị achịkwa n'ime oyi akwa basal, ọ na-akwalite nkwupụta mkpụrụ ndụ ihe nketa nke protein ndị metụtara njedebe. Ọgba aghara dị iche iche nke cellular na-esite na ịka nká, nrụgide gburugburu ebe obibi, ma ọ bụ kpọmkwem ọnọdụ akpụkpọ ahụ na-esi otú a na-emegide nke ọma.
Nke zuru oke, na-arụ ọrụ mgbochi anụ ahụ siri ike; ụbara hydration nke akpụkpọ ahụ bụ nsonaazụ kpọmkwem, agba dị nro ma nụchaa bụ ebe njedebe nke usoro a.
3.Iwu Skin nwere mmetụta na enyemaka nke itching / erughị ala jikọtara
Mmekọrịta na ndị nnata na neurons sensory bụ isi usoro; na-emegharị ahụ ọwa ion si otú a na-achịkwa excitability akwara.
A na-egbochi ihe nzuzo na-akpata mkpali, na ọnụ ụzọ mmetụta dị elu na-eduga na mbelata dị ukwuu ma ọ bụ ikpochapụ ọkụ, agba agba, itching na tightness. A na-edobe nnabata nrụgide gburugburu ebe obibi ogologo oge n'ogo akwara a.
4.Na-akwalite uto Axonal na Mmezi Neural
Ndị na-anata elu neuronal akọwapụtara bụ ebumnuche nke Hexapeptide-10.
Nke a na-akpata cascades intracellular (Focal Adhesion Kinase na Src ezinụlọ kinase) nke na-eme ka ụzọ okwu okwu dị n'okpuru ala maka uto na ọdịiche. Cytoskeletal A na-edozi njikọ protein na nhazigharị n'ime neuron n'onwe ya.
Ọmụmụ ihe gbasara biomaterial egosila na-emegharị axon iji soro ntụzịaka scaffold akọwapụtara, na-eweghachi njikọ na anụ ahụ ezubere iche. Nrụzi akwara na anụ ahụ bụ nsonaazụ ozugbo nke usoro ndị a.
COA
HPLC
MS
