Hexapeptide-10, or more formally referred to as SIKVAV/Serilesine, is the smallest functional unit precisely isolated from the globular domain of the laminin α1 chain. Exceptionally high biological activity is a defining characteristic of this peptide.
Early studies have shown greater cell adhesion-promoting and, to a large extent, axonal growth-stimulating capabilities when compared to intact laminin. Specific recognition and subsequent activation of various integrins and other surface receptors is another key property; tăng sinh tế bào, sự khác biệt, and survival all follow as direct consequences.
Within khoa học thần kinh, therapeutic potential for repairing damage to the central or peripheral nervous system được ghi lại rõ ràng. The cosmetic field has recently seen a significant rise in its prominence.
Hexapeptide-10, given its neuromodulatory and tissue-repairing potential, is a vital component of both cosmetic and dermatological science.
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Sự liên tiếp
H-Ser-Ile-Lys-Val-Ala-Val-OH
Số CAS
146439-94-3
Công thức phân tử
C28H53N7O8
Trọng lượng phân tử
615.77
Hexapeptide-10 Related Research
1.Skin Repair and Homeostasis Regulation
Extensive grafting or surface modification of vật liệu sinh học with Hexapeptide-10 allows for the induction of stem cell differentiation, nguyên bào sợi/endothelial cell proliferation and directed migration – thereby accelerating skin wound healing.
Precise regulation of tế bào sừng proliferation-differentiation balance is what sets it apart; excessive basal layer epidermal proliferation is moderated, promoting orderly division of the lớp sừng.
Skin structural strength and overall integrity are improved, texture being a primary concern. Neural signaling pathways are also modulated, reducing skin’s sensitivity to external stimuli; sensitive skin in particular benefits from all of the above.
2.Regulating keratinocyte proliferation and differentiation to maintain skin homeostasis
Hexapeptide-10 directly acts on epidermal cells, balancing their proliferation and subsequent differentiation.
Inhibiting irregular differentiation and uncontrolled division within the basal layer, it upregulates the gene expression of terminal differentiation-associated proteins. Cellular differentiation disorders resulting from aging, environmental stress, or specific skin conditions are thus effectively counteracted.
A more complete, functionally robust physical barrier is formed; increased hydration of the skin is a direct result, smoother and refined complexion being the end point of this process.
3.Sensitive Skin Regulation and Relief of associated Itching/Discomfort
Interaction with receptors on sensory neurons is the key mechanism; modulating ion channels thereby regulates neural excitability.
Pro-inflammatory factor secretion is inhibited, and an elevated sensory threshold leads to significant reduction or elimination of burning, chua cay, itching and tightness. Long term environmental stress tolerance is thereby maintained at this neural level.
4.Promoting Axonal Growth and Neural Repair
Specific neuronal surface receptors are the targets of Hexapeptide-10.
This triggers intracellular cascades (Focal Adhesion Kinase Và Src family kinases) that activate downstream gene expression pathways for growth and differentiation. Cytoskeletal protein synthesis and reorganization is upregulated within the neuron itself.
Biomaterial studies have shown regenerating axons to follow defined scaffold orientations, re-establishing connectivity with target tissues. Neural and skin tissue repair is a direct outcome of these processes.
COA
HPLC
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