What is KPV peptide：KPV is a synthetic bioactive peptide derived from the C-terminal ultra-short tripeptide fragment of naturally occurring α-Melanocyte-Stimulating Hormone (α-MSH). Research into various α-MSH fragments led scientists to discover that the specific C-terminal sequence KPV – comprising those very last three amino acids – loses its melanogenesis promoting effect; emelitere nke ọma mgbochi mkpali na immunomodulatory Njirimara, Otú ọ dị, na-ejigide.
KPV n'onwe ya na-eme site na usoro na-abụghị ergoline; Mgbochi nke ịgbalite na ntinye ederede nke isi ihe mkpali bụ usoro izizi. Otutu cytokines pro-inflammatory na-esi otú ahụ ebelata nke ọma na mmepụta na ntọhapụ.
Mgbanwe nke mkpụrụ ndụ na-alụso ọrịa ọgụ kpọmkwem (lymphocytes, macrophages n'etiti ndị ọzọ) bụ akụkụ ọzọ bụ isi nke mmetụta ya, na-emezigharị gburugburu ebe mgbochi mkpali nke ime ahụ. A na-akpali nrụzi ihe na-egbuke egbuke ma na-abawanye ọrụ mgbochi mkpali n'ozuzu ya.
Nnwale ụlọ ọgwụ egosila ọganihu doro anya na nnwale colitis; belatara mucosal edema, nchebe nke mgbochi eriri afọ ọrụ, na ụdị dị iche iche nke nrụzi larịị anụ ahụ/cell bụ ihe niile enwere ike ịtụtụrụ.
Obere molekụla dị ala nke KPV bụ uru ọzọ dị ịrịba ama, na-enye ezigbo bioavailability ọnụ yana ikike nnabata transdermal ama ama. Nlekọta ọnụ na-enye ya ohere iguzogide mmebi site na eriri afọ enzymes wee rute eriri afọ usoro mgbochi mucosal ozugbo.
Usoro
H-Lys-Pro-Val-OH
Nọmba CAS
67727-97-3
Usoro ihe omimi
C16H30N4O4
Ibu molekụla
342.44
Nnyocha nke KPV Peptide
1.Ọrụ mgbochi mkpali
Nke a bụ etiti, ọrụ mbụ nke KPV. Edobere isi ihe NF-κB n'ime ụzọ mgbaàmà mkpali cellular, igbochi usoro ịgbalite / ntụgharị bụ ihe na-akọwa ihe omume ya.
Akwụsịla nkwupụta na ndegharị nke ndị mgbasa ozi pro-inflammatory na isi iyi. A na-akwalitekwa ihe mgbochi mkpali.
Ịgbanwe gburugburu mkpali cellular bụ isi njedebe nke omume nchịkwa abụọ nke KPV.
2.Mmetụta Immunomodulatory
Ọrụ immunoregulatory KPV sitere na ọrụ mgbochi mkpali ya nwere ike. Na-egbochi nkwupụta nke mkpụrụ ndụ ihe nketa M1 pro-inflammatory, ọrụ a na-eme ka osooso na-aga n'ihu na-emezigharị M2 phenotype polarization – isi usoro nchịkwa n'ime usoro ahụ ji alụso ọrịa ọgụ.
Nlekọta na-aga n'ihu nke KPV na ụmụ oke na-egosipụta nzaghachi mkpali na otu nnwale na-egosi ma ọ bụ belata mbufụt., ma ọ bụ mkpebi ya zuru oke; ọrụ physiological na-ejikọta chiri anya na njikwa ahụike.
3.Mmetụta Nchekwa akọwapụtara nke ọma na Ọrịa Bowel Na-efe efe (IBD)
KPV gosipụtara uru ngwa pụrụ iche na ahụike eriri afọ.
Ụdị òké nke mbufụt na-egosi ọganihu doro anya IBD(Ọrịa afọ na-efe efe) mgbaàmà site na nchịkwa ọnụ. Mmebi nke eriri afọ, edema, erosions, na ntinye nke cell mkpali na-ebelata nke ukwuu.
Imezi na ime ka iguzosi ike n'ezi ihe nke mgbochi mucosal sie ike bụ otu n'ime omume mbụ KPV.; mbelata permeability nke eriri afọ na-esote. A na-egbochi nje bacteria na antigens ha ịtụgharị gafee mgbochi eriri afọ, si otú a na-egbochi imebiga ihe ókè nke usoro ahụ ji alụso ọrịa ọgụ na ihe kpatara ya.
Ọgwụgwọ nke mucosa n'onwe ya bụ nsonaazụ kpọmkwem nke mmetụta nchebe ndị a.
4.Na-akwalite Mmezi na Mmegharị Tissue
Site n'igbochi mbufụt, KPV na-emepụta microenvironment cellular emelitere ka nrụzi dị otú ahụ mee.
A na-eme ka ihe nrụzi mgbochi mkpali na cell rụọ ọrụ. Nnyocha egosiwo nrụzi ngwa ngwa na mmụgharị nke mkpụrụ ndụ epithelial intestinal na sel epidermal akpụkpọ anụ na ihe ndị a na-agwọ KPV..
Ọgwụgwọ ọnya, na ihe niile na-esote, bụ akụkụ nke ihe KPV nwere ike imezu.
COA
HPLC
MS
